LasR-IN-2
LasR-IN-2 is a LasR inhibitor that forms H-bonding with TRY-56 residue. LasR-IN-2 can be used in the research of bacterial infection, neutropenia, severe burns and chronic lung disease in cystic fibrosis (CF).
For research use only. We do not sell to patients.
- CAS No.: 3033530-61-6
- Formula: C21H16ClN3O2
- Molecular Weight:377.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
LasR[1]
LasR-IN-2 (Compound 8a, 4.68-150 μg/mL, 24 h) inhibits P. aeruginosa growth[1].
LasR-IN-2 (18.5 μM, 24 h) inhibits biofilm formation, pyocyanin production, and rhamnolipids production[1].
LasR-IN-2 (24 h) inhibits human dermal fibroblasts (HDFa) growth with an IC50 value of 102 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:P. aeruginosa (ATCC27853)
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Concentration:4.68-150 μg/mL
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Incubation Time:24 h
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Result:Inhibited bacterial growth with a MIC value of 74.40 μM.
Chemical Information
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CAS No. 3033530-61-6
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Molecular Weight 377.82
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Formula C21H16ClN3O2
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SMILES
O=C(NC1=CC=CC=C1)COC2=CC=C(C3=NC4=CC(Cl)=CC=C4N3)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Rehab H Abd El-Aleam, et al. Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation. Eur J Med Chem. 2022 Aug 5;241:114629. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LasR-IN-2 Related Classifications
HY-151164 Related Classifications
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