3033530-61-6
3033530-61-6
Chemical Structure
LasR-IN-2
- CAS No.: 3033530-61-6
- Formula:C21H16ClN3O2
- Molecular Weight:377.82
IUPAC Name: 2-(4-(5-chloro-1H-benzo[d]imidazol-2-yl)phenoxy)-N-phenylacetamide
InChIKey: YZHQMFNEXBQKHA-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC=C1)COC2=CC=C(C3=NC4=CC(Cl)=CC=C4N3)C=C2
Biological Activity: LasR-IN-2 is a LasR inhibitor that forms H-bonding with TRY-56 residue. LasR-IN-2 can be used in the research of bacterial infection, neutropenia, severe burns and chronic lung disease in cystic fibrosis (CF)[1].
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LasR-IN-2 | LasR-IN-2 is a LasR inhibitor that forms H-bonding with TRY-56 residue. LasR-IN-2 can be used in the research of bacterial infection, neutropenia, severe burns and chronic lung disease in cystic fibrosis (CF). | |||||||||||||||||||||
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References
- [1]. Rehab H Abd El-Aleam, et al. Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation. Eur J Med Chem. 2022 Aug 5;241:114629. [Content Brief]
Keywords
