Gallium hematoporphyrin  (Synonyms: GaHP)

Gallium hematoporphyrin is a heme analogue and a selective targeting agent against Mycobacteroides abscessus. Gallium hematoporphyrin induces ROS production and inhibits biofilm formation as well as disrupts preformed biofilms in both smooth and rough colony morphotypes of Mycobacteroides abscessus. Gallium hematoporphyrin interferes with heme-dependent metabolic pathways and suppresses the growth of clinical Mycobacteroides abscessus isolatess, with MICs ranging from 0.5 to 1 μg/ml. Gallium hematoporphyrin exhibits synergistic antibacterial activity with Clarithromycin (HY-17508) against Mycobacteroides abscessus. Gallium hematoporphyrin can be used for the research of Mycobacteroides abscessus infection^[1].

Gallium hematoporphyrin (GaHP) (0.5-1 μg/mL) inhibits growth of clinical M. abscessus isolates (including smooth and rough morphotypes) in iron-limited 7H9 media, with MICs of 0.5 and 1 μg/mL^[1].
Gallium hematoporphyrin (0.0625 μg/mL; in combination with clarithromycin) acts synergistically with clarithromycin against M. abscessus, with an FICI of 0.31 and an FIC of 0.0625 μg/mL for GaHP^[1].
Gallium hematoporphyrin (up to 32 μg/mL) is non-toxic to Vero E6 cells^[1].
Gallium hematoporphyrin (1 μg/mL (1.5 μM); 65 h) inhibits M. abscessus growth by targeting heme utilization pathways, as shown by growth rescue with hemin but not FAC at a GaHP concentration of 1 μg/mL (1.5 μM) over 65 h^[1].
Gallium hematoporphyrin (0.03-16 μg/mL; 3 h) induces concentration-dependent ROS production in M. abscessus at concentrations of 0.03 to 8 μg/mL after 3 h of incubation, with reduced ROS at 16 μg/mL due to cell death^[1].
Gallium hematoporphyrin (8 μg/mL) inhibits biofilm formation by smooth and rough M. abscessus morphotypes in iron-rich media, with ~60% inhibition of smooth variants and ~30% inhibition of rough variants^[1].
]Gallium hematoporphyrin (16 μg/mL) disrupts preformed biofilms of smooth and rough M. abscessus morphotypes, with ~50% disruption of smooth variant biofilms and ~40% disruption of rough variant biofilms^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

703.86

C₃₄H₃₈ClGaN₄O₆

CC1=C(C2=CC3=N4C(C(C)=C3CCC(O)=O)=CC5=C(C(C(O)C)=C6C=C7C(C)=C(C8=N7[Ga]4(N2C1=C8)(N56)Cl)C(O)C)C)CCC(O)=O

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• [1]. Choi SR, et al. Gallium Hematoporphyrin inhibits Mycobacteroides abscessus in vitro, including biofilm formation and stability. Bioorg Med Chem Lett. 2026;131:130466.  [Content Brief]