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Cat. No.: HY-D3195

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CDr15

CDr15 is a deep-red fluorescent probe (Ex=733 nm) that can selectively intercalate into and label bacterial extracellular DNA (eDNA). CDr15 exhibits extremely high specificity for biofilm imaging and cannot effectively bind to mammalian nuclear DNA. CDr15 enables real-time visualization of the microcolony structure and developmental process of three-dimensional *Pseudomonas aeruginosa* biofilms, and accurately localizes biofilm-forming regions of microorganisms in a mouse corneal infection model. With low background interference signals, CDr15 serves as an ideal diagnostic tool for research fields including bacterial biofilms and corneal infections.

For research use only. We do not sell to patients.

CAS No.: 2028316-19-8
Formula: C₂₇H₂₇BF₂N₄O
Molecular Weight:472.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDr15 Chemical Structure

CAS No.: 2028316-19-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

In Vitro

CDr15 binds to DNA via intercalation, with enhanced fluorescence upon binding, and exhibits differential fluorescence responses to DNA versus RNA^[1].
CDr15 (stained for 30 minutes; biofilm cultured for 1-5 days) selectively stains the eDNA component within the extracellular matrix of P. aeruginosa biofilms, with distinct spatial localization in developing biofilms, while not staining biofilms lacking eDNA or planktonic bacteria^[1].
CDr15 does not stain the nuclei of live or treated HEK293 cells and is selective for mammalian nuclear DNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2028316-19-8
Molecular Weight 472.34
Formula C₂₇H₂₇BF₂N₄O
SMILES

CC(C=C1/C=C/C2=CC=C(N(CCO)C)C=C2)=C(N1[B-]3(F)F)C(C4=CC=C(N)C=C4)=C5[N+]3=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kwon HY , et al. Visualizing biofilm by targeting eDNA with long wavelength probe CDr15. Biomater Sci. 2019;7(9):3594-3598. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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