Antifungal agent 40
Antifungal agent 40 is an antifungal agent which extends into the narrow hydrophobic pocket II of C.alb. CYP51. Antifungal agent 40 has an inhibitory effect on lanosterol 14α-demethylase (CYP51). Antifungal agent 40 inhibits biofilm formation.
For research use only. We do not sell to patients.
- CAS No.: 3033702-89-2
- Formula: C22H20Cl2N4Se
- Molecular Weight:490.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
CYP51[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
5.18 μM
Compound: A03
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Cytotoxicity against human HL-60 cells by MTT assay
Cytotoxicity against human HL-60 cells by MTT assay
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[PMID: 36057236] |
| MDA-MB-231 | IC50 |
3.25 μM
Compound: A03
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Cytotoxicity against human MDA-MB-231 cells by MTT assay
Cytotoxicity against human MDA-MB-231 cells by MTT assay
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[PMID: 36057236] |
| PC-3 | IC50 |
0.98 μM
Compound: A03
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Cytotoxicity against human PC-3 cells by MTT assay
Cytotoxicity against human PC-3 cells by MTT assay
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[PMID: 36057236] |
Antifungal agent 40 (compound A03, 0.25-128 μg/mL) inhibits fungal activity with MIC values of 1-64 μg/mL[1].
Antifungal agent 40 (1-8 μg/mL, 16 h) inhibits lanosterol 14α-demethylase (CYP51) of C.alb (GC-MS analysis)[1].
Antifungal agent 40 (0.5 μg/mL, 1.5-24 h) displays antibiofilm activity against FCZ-Resistant C.alb[1].
Antifungal agent 40 (0-10 μM respectively) shows cytotoxicity against HL-60, MDA-MB-231 and PC-3 cells with IC50 values of 5.18, 3.25, 0.98 μM respectively[1].
Antifungal agent 40 (2-32 μg/mL, 3 h) displays high hemolysis rate in rabbit erythrocyte[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3033702-89-2
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Molecular Weight 490.29
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Formula C22H20Cl2N4Se
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SMILES
ClC1=CC=C(C([Se]C(C2=CC=C(Cl)C=C2)CN3C=CN=C3)CN4C=CN=C4)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antifungal agent 40 Related Classifications
HY-151437 Related Classifications
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