Antibacterial agent 337 

Antibacterial agent 337 is an antibacterial agent. Antibacterial agent 337 specifically interacts with PG in bacterial cell membranes, triggering membrane disruption, membrane depolarization, increased permeability, cytoplasmic leakage, ROS accumulation and rapid bacterial death. Antibacterial agent 337 inhibits biofilm formation and disrupts mature biofilms. Antibacterial agent 337 exhibits potent in vivo antibacterial efficacy in a mouse model of Staphylococcus aureus skin abscess. Antibacterial agent 337 can be used in studies of Gram-positive bacterial infections, including methicillin-resistant Staphylococcus aureus infections, vancomycin-resistant Enterococcus faecalis infections and bacterial biofilm infections^[1].

Antibacterial agent 337 (Compound 10 b) (0-64 μg/mL; 8 h for S. aureus, 2 h for HEK293T) selectively neutralizes the anionic surface charge of S. aureus ATCC25923 in a concentration-dependent manner, while exerts no effect on the zeta potential of HEK293T mammalian cells^[1].
Antibacterial agent 337 (0-128 μg/mL, 24 h) exhibits potent antibacterial activity against Gram-positive bacteria (S. aureus 25923, S. aureus 43300, E. faecalis 29212, E. faecalis 51299, B. subtilis 9372) with an MIC of 1-4 μg/mL, while shows weak activity against Gram-negative bacteria^[1].
Antibacterial agent 337 inhibits biofilm formation of S. aureus ATCC25923, binds specifically to phosphatidylglycerol (PG), and significantly increases ROS^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 337 (5-10 mg/kg; subcutaneous injection; single dose) exhibits potent in vivo antibacterial efficacy in a mouse Staphylococcus aureus skin abscess model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1343.33

C₇₈H₉₂Br₂N₂O₄P₂

C=CCC1=CC=C(OCC(N(CCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)CCCCCC)=O)C(C5=CC=C(OCC(N(CCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)CCCCCC)=O)C(CC=C)=C5)=C1.[Br-].[Br-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu J, et al. Development of membrane-targeting honokiol derivatives as antibacterial agents against gram-positive bacteria. Bioorg Chem. 2026;175:109814.