2. Anti-infection Neuronal Signaling Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Fungal Bacterial Amyloid-β Reactive Oxygen Species (ROS) Proteasome
  4. 10-Undecenoic acid zinc salt

10-Undecenoic acid zinc salt  (Synonyms: Zinc undecylenate)

Cat. No.: HY-B0914A Purity: 98.0%
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10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa.

For research use only. We do not sell to patients.

10-Undecenoic acid zinc salt

10-Undecenoic acid zinc salt Chemical Structure

CAS No. : 557-08-4

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Based on 2 publication(s) in Google Scholar

Other Forms of 10-Undecenoic acid zinc salt:

10-Undecenoic acid zinc salt Related Antibodies

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  • Purity & Documentation

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Description

10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa[1][2][3][4][5][6][7][8].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

Preparations (1.6-3.8 mM; 3-6 h) of 10-Undecenoic acid zinc salt complexed with L-arginine induces apoptosis in tumor cells (A549 and Jurkat)[2].
10-Undecenoic acid zinc salt (24 h) shows dose-dependent cytotoxicity to human tumor cell lines HeLa, A549, Jurkat, and U937, with IC50s of 0.9862, 0.3751, 0.5782, 0.2893 mM, respectively[2].
10-Undecenoic acid zinc salt (up to 5 μM) significantly increases the expression and activity of alkaline phosphatase and calcium deposition, and induces the expression of the osteocalcin gene in mouse osteoblastic MC3T3-E1 subclone 4 cells and primary mouse calvarial cells[3].
10-Undecenoic acid zinc salt reduces the number of viable and active cells and makes the biofilm thinner in C. albicans biofilms, while it increases the cell count, metabolic activity and proteinase activity in C. glabrata biofilms[4].
10-Undecenoic acid zinc salt (20 μM) shows neuroprotective effect against glutamate, H2O2 and Aβ1-42 induced cell death in SH-SY5Y cells[5].
10-Undecenoic acid zinc salt (1-40 mM; 6-24 h) reduces the cell death induced by H2O2, partially attenuates the cell death induced by Staurosporine (HY-15141) and Ddoxorubicin (HY-15142A) in SH-SY5Y cells[6].
10-Undecenoic acid zinc salt (12.5-50 μg/mL) causes a reduction of LuxS/AI-2QS system in B. subtilis, and (15.625-250 μg/mL) causes a 10-54% reduction of LasI/LasR QS system in P. aeruginosa[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

10-Undecenoic acid zinc salt Related Antibodies

Cell Differentiation Assay[3]

Cell Line: Mouse osteoblastic MC3T3-E1 subclone 4 cells, primary mouse calvarial cells
Concentration: 2.5 μM, 5 μM
Incubation Time: During osteoblast differentiation (up to 18 days for some assays)
Result: Significantly increased the expression and activity of alkaline phosphatase at day 9 of differentiation (MC3T3-E1 subclone 4 cells).
Induced mineralization at day 15 and 18 (MC3T3-E1 subclone 4 cells).
Significantly induced calcium deposition at differentiation day 28 (primary mouse calvarial cells).
Regulated the mRNA expression levels of osteocalcin (OCN), Fra-2 and NFATc1 in both cell types.
In Vivo

10-Undecenoic acid zinc salt (arginine undecylenate (GS-1) form, 157.6 mg/mL; topical administration; twice a day; 6 days) effectively clears MRSA infections in the epidermal and dermal layers in a rat model of MRSA skin infection[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

431.91

Formula

C22H38O4Zn
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C=CCCCCCCCCC([O-])=O.C=CCCCCCCCCC([O-])=O.[Zn+2]
Structure Classification
Initial Source

Escherichia coli
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (11.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3153 mL 11.5765 mL 23.1530 mL
5 mM 0.4631 mL 2.3153 mL 4.6306 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.5 mg/mL (1.16 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 0.5 mg/mL (1.16 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3153 mL 11.5765 mL 23.1530 mL 57.8824 mL
5 mM 0.4631 mL 2.3153 mL 4.6306 mL 11.5765 mL
10 mM 0.2315 mL 1.1576 mL 2.3153 mL 5.7882 mL
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10-Undecenoic acid zinc salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10-Undecenoic acid557-08-4Zinc undecylenateFungalBacterialAmyloid-βReactive Oxygen Species (ROS)Proteasomeβ-amyloid peptideAβAbetaRdRpHuh7ZIKVanti-infectivevirusanti-fungalInhibitorinhibitorinhibit

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