1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Bacitracin Zinc

Bacitracin Zinc  (Synonyms: Zinc bacitracin)

Cat. No.: HY-B0278 Purity: 98.76%
COA Handling Instructions

Bacitracin Zinc (Zinc bacitracin) is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.

For research use only. We do not sell to patients.

Bacitracin Zinc Chemical Structure

Bacitracin Zinc Chemical Structure

CAS No. : 1405-89-6

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Description

Bacitracin Zinc (Zinc bacitracin) is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM. Target: Antibacterial Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Its unique name derives from the fact that the bacillus producing it was first isolated in 1943 from a knee scrape from a girl named Margaret Tracy. As a toxic and difficult-to-use antibiotic, bacitracin doesn't work well orally. However, it is very effective topically. Bacitracin is synthesised via the so-called nonribosomal peptide synthetases (NRPSs), which means that ribosomes are not involved in its synthesis [1, 2].

Molecular Weight

1486.06

Formula

C66H101N17O16SZn

CAS No.
SMILES

O=C([[email protected]](NC([[email protected]@H](CCCN)NC([[email protected]](CCCCNC1=O)NC([[email protected]]([[email protected]@H](C)CC)NC([[email protected]@H](CCC([O-])=O)NC([[email protected]@H](NC(C2CSC(C(C(CC)C)N)=N2)=O)CC(C)C)=O)=O)=O)=O)=O)[[email protected]](C)CC)N[[email protected]@H](C(N[[email protected]](CC3=CN=CN3)C(N[[email protected]](CC([O-])=O)C(N[[email protected]]1CC(N)=O)=O)=O)=O)CC4=CC=CC=C4.[Zn+2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

1M HCl : 50 mg/mL (33.65 mM; Need ultrasonic)

H2O : 1 mg/mL (0.67 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6729 mL 3.3646 mL 6.7292 mL
5 mM 0.1346 mL 0.6729 mL 1.3458 mL
10 mM 0.0673 mL 0.3365 mL 0.6729 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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