IITR08367
IITR08367 is a potent effector pump Acinetobacter baumannii Fosfomycin Efflux pump (AbaF) inhibitor for enhancing the antimicrobial activity of Fosfomycin (HY-B1075A) against Acinetobacter baumannii. IITR08367 acts by interfering with Fosfomycin/H+ reverse transporter activity. .
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- CAS No.: 20193-94-6
- Formule: C16H18S2
- Masse moléculaire:274.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IITR08367 (0-50 μM) concentration-dependently enhances the activity of Fosfomycin against AbaF-expressing strain of Escherichia coli. A concentration of 50 μM can increase the postantibiotic effect of Fosfomycin by 30 min[1].
IITR08367 (25 μM; 16 min) disrupts the H+ gradient across the membrane, ultimately inhibiting the H+ gradient-driven efflux pump without causing membrane damage[1].
IITR08367 (100 μM; 12 h) and Fosfomycin (64 mg/L) in combination can inhibit A. baumannii RPTC-15 growth[1].
IITR08367 (100 μM) eliminates the Biofilm Forming Ability of A. baumannii with and without the addition of Fosfomycin[1].
IITR08367 (12.5-200 μM) is not toxic to erythrocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RBCs
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Concentration:12.5; 25; 50; 100; 200 μM
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Incubation Time:6 h
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Result:Showed less than 40% cytotoxicity till 200 µM
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Urinary tract infections mice[1]
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Dosage:30 mg/kg; every 12 h for 54 h
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Administration:i.p.
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Result:Reduced the load of A. baumannii RPTC-15 in the kidney and bladder by approximately 3log10.
Chemical Information
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CAS No. 20193-94-6
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Masse moléculaire 274.44
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Formule C16H18S2
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SMILES
CC1=CC=C(CSSCC2=CC=C(C)C=C2)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IITR08367 Related Classifications
HY-163473 Related Classifications
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