IITR08367
IITR08367 is a potent effector pump Acinetobacter baumannii Fosfomycin Efflux pump (AbaF) inhibitor for enhancing the antimicrobial activity of Fosfomycin (HY-B1075A) against Acinetobacter baumannii. IITR08367 acts by interfering with Fosfomycin/H+ reverse transporter activity. .
For research use only. We do not sell to patients.
- CAS No.: 20193-94-6
- Formula: C16H18S2
- Molecular Weight:274.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
IITR08367 (0-50 μM) concentration-dependently enhances the activity of Fosfomycin against AbaF-expressing strain of Escherichia coli. A concentration of 50 μM can increase the postantibiotic effect of Fosfomycin by 30 min[1].
IITR08367 (25 μM; 16 min) disrupts the H+ gradient across the membrane, ultimately inhibiting the H+ gradient-driven efflux pump without causing membrane damage[1].
IITR08367 (100 μM; 12 h) and Fosfomycin (64 mg/L) in combination can inhibit A. baumannii RPTC-15 growth[1].
IITR08367 (100 μM) eliminates the Biofilm Forming Ability of A. baumannii with and without the addition of Fosfomycin[1].
IITR08367 (12.5-200 μM) is not toxic to erythrocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:RBCs
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Concentration:12.5; 25; 50; 100; 200 μM
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Incubation Time:6 h
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Result:Showed less than 40% cytotoxicity till 200 µM
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Urinary tract infections mice[1]
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Dosage:30 mg/kg; every 12 h for 54 h
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Administration:i.p.
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Result:Reduced the load of A. baumannii RPTC-15 in the kidney and bladder by approximately 3log10.
Chemical Information
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CAS No. 20193-94-6
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Molecular Weight 274.44
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Formula C16H18S2
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SMILES
CC1=CC=C(CSSCC2=CC=C(C)C=C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IITR08367 Related Classifications
HY-163473 Related Classifications
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