1. Anti-infection
  2. Bacterial
  3. RhlR antagonist 1

RhlR antagonist 1 

Cat. No.: HY-131337
Handling Instructions

RhlR antagonist 1 is a potent RhlR antagonist with an IC50 of 26 μM. RhlR antagonist 1 displays selective RhlR antagonism over LasR and PqsR, strong inhibition of biofilm formation in static and dynamic settings, and reduces production of virulence factors such as rhamnolipid and pyocyanin in P. aeruginosa. RhlR antagonist 1 can be utilized for developing QS-modulating molecules in the control of P. aeruginosa infections.

For research use only. We do not sell to patients.

RhlR antagonist 1 Chemical Structure

RhlR antagonist 1 Chemical Structure

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Description

RhlR antagonist 1 is a potent RhlR antagonist with an IC50 of 26 μM. RhlR antagonist 1 displays selective RhlR antagonism over LasR and PqsR, strong inhibition of biofilm formation in static and dynamic settings, and reduces production of virulence factors such as rhamnolipid and pyocyanin in P. aeruginosa. RhlR antagonist 1 can be utilized for developing QS-modulating molecules in the control of P. aeruginosa infections[1].

In Vitro

RhlR antagonist 1 (compound 30) (10 μM) inhibits P. aeruginosa biofilm formation by 74% and decreases the amount of carbohydrate and protein by 39 and 72%, respectively. RhlR antagonist 1 reduces significantly rhamnolipid production by P. aeruginosa at 10 and 100 μM concentrations. RhlR antagonist 1 (0-10 μM; 24 hours) down-regulates rhlA expression of biofilm cells. RhlR antagonist 1 could inhibit P. aeruginosa biofilm formation and virulence factor production by down-regulating the rhlA expression of PP. aeruginosa[1].

In Vivo

Larvae injected with P. aeruginosa started to die in initial incubation time and 70% of them died at the end of the 20-day incubation period. The survival rate of RhlR antagonist 1 (0-10 μM)-treated larvae is greatly improved, with approximately 80% larvae surviving at the end of the incubation period. In addition, larvae injected with rhlR mutants of P. aeruginosa shows a 90% survival rate after 20 days[1].

Molecular Weight

208.20

Formula

C₁₂H₁₀F₂O

SMILES

CCCC(C#CC1=CC=C(F)C(F)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RhlR antagonist 1RhlR antagonist1RhlR antagonist-1BacterialselectivebiofilmformationrhamnolipidproductionvirulencefactorQSInhibitorinhibitorinhibit

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RhlR antagonist 1
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HY-131337
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