2. Anti-infection
  3. Bacterial
  4. MSU-43557

MSU-43557 is a Mycobacterium abscessus MmpL3 (MAB_4508) inhibitor and bactericidal agent. MSU-43557 inhibits MmpL3 function, disrupts trehalose monomycolate synthesis, and reduces biofilm-associated Mycobacterium abscessus viability. MSU-43557 exerts bactericidal activity against intracellular Mycobacterium abscessus. MSU-43557 shows low eukaryotic cytotoxicity and low Mycobacterium abscessus resistance frequency. MSU-43557 can be used for the research of mycobacterium abscessus infection.

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MSU-43557

MSU-43557 Chemical Structure

CAS No. : 2919699-59-3

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MSU-43557 Related Antibodies

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Description

MSU-43557 is a Mycobacterium abscessus MmpL3 (MAB_4508) inhibitor and bactericidal agent. MSU-43557 inhibits MmpL3 function, disrupts trehalose monomycolate synthesis, and reduces biofilm-associated Mycobacterium abscessus viability. MSU-43557 exerts bactericidal activity against intracellular Mycobacterium abscessus. MSU-43557 shows low eukaryotic cytotoxicity and low Mycobacterium abscessus resistance frequency. MSU-43557 can be used for the research of mycobacterium abscessus infection[1].

In Vitro

MSU-43557 (80 μM-0.08 nM; 3 d) potently inhibits the growth of Mycobacterium abscessus ATCC 19977 in vitro, and exhibits time-dependent bactericidal activity at a concentration of 5× MIC; meanwhile, MSU-43557 potently inhibits strains of Mycobacterium tuberculosis, Mycobacterium abscessus and Mycobacterium smegmatis, shows no activity against non-mycobacterial species within 80 μM, and displays variable inhibitory activity against clinically isolated multidrug-resistant Mycobacterium abscessus strains[1].
MSU-43557 (0.18 nM-160 μM; 3 d) disrupts mature Mycobacterium abscessus biofilms with an EC50 of 8.66 μM; it also reduces bacterial viability within biofilms, with a corresponding EC50 of 0.16 μM[1].
MSU-43557 (0.18 nM-160 μM; 3 d) kills intracellular Mycobacterium abscessus ATCC 19977 in mouse bone marrow-derived macrophages with an EC50 of 0.39 μM, and exhibits low cytotoxicity toward mouse bone marrow-derived macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MSU-43557 Related Antibodies

Cell Viability Assay[1]

Cell Line: Mycobacterium tuberculosis strains, Mycobacterium abscessus, and Mycobacterium smegma
Concentration: 80 μM-0.08 nM
Incubation Time: 3 d
Result: Inhibited the growth of Mycobacterium abscessus ATCC 19977 by an EC50 of 1.29 μM and a MIC of 3.69 μM.
Effectively inhibited Mycobacterium tuberculosis strains (EC50 value of 0.13 to 0.19 μM), Mycobacterium abscessus (EC50 of 1.82 μM), and Mycobacterium smegma (EC50 of 2.54 μM).

Cell Cytotoxicity Assay[1]

Cell Line: Murine bone marrow-derived macrophages (BMMΦ)
Concentration: 200 to 0.13 μM
Incubation Time: 3 d
Result: Resulted in a CC50 of >80 μM, indicating low cytotoxicity relative to intracellular efficacy.
Molecular Weight

326.22

Formula

C15H17Cl2N3O
CAS No.
SMILES

CC1(CCCCC1)C(NC2=NC3=CC(Cl)=C(Cl)C=C3N2)=O
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Purity & Documentation
References
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MSU-43557 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MSU-435572919699-59-3MSU43557MSU 43557BacterialMycobacterium abscessus ATCC 19977mycolic acid transportMycobacterium abscessus mmpL3 mutantsbiofilm-associated Mycobacterium abscessusMmpL3murine bone marrow-derived macrophagesMAB_4508Mycobacterium abscessusintracellular Mycobacterium abscessustrehalose monomycolate synthesisInhibitorinhibitorinhibit

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