2919699-59-3
Chemical Structure
MSU-43557
- CAS No.: 2919699-59-3
- Formula:C15H17Cl2N3O
- Molecular Weight:326.22
InChIKey: BWEHEKPWFWCDPK-UHFFFAOYSA-N
SMILES: CC1(CCCCC1)C(NC2=NC3=CC(Cl)=C(Cl)C=C3N2)=O
Biological Activity: MSU-43557 is a Mycobacterium abscessus MmpL3 (MAB_4508) inhibitor and bactericidal agent. MSU-43557 inhibits MmpL3 function, disrupts trehalose monomycolate synthesis, and reduces biofilm-associated Mycobacterium abscessus viability. MSU-43557 exerts bactericidal activity against intracellular Mycobacterium abscessus. MSU-43557 shows low eukaryotic cytotoxicity and low Mycobacterium abscessus resistance frequency. MSU-43557 can be used for the research of mycobacterium abscessus infection[1].
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MSU-43557 | MSU-43557 is a Mycobacterium abscessus MmpL3 (MAB_4508) inhibitor and bactericidal agent. MSU-43557 inhibits MmpL3 function, disrupts trehalose monomycolate synthesis, and reduces biofilm-associated Mycobacterium abscessus viability. MSU-43557 exerts bactericidal activity against intracellular Mycobacterium abscessus. MSU-43557 shows low eukaryotic cytotoxicity and low Mycobacterium abscessus resistance frequency. MSU-43557 can be used for the research of mycobacterium abscessus infection. | |||||||||||||||||||||
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Keywords
