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  4. Dihydroaeruginoic acid

Dihydroaeruginoic acid  (Synonyms: (Rac)-CGP 52547)

製品番号: HY-W718262
取扱説明書 Technical Support

Dihydroaeruginoic acid ((Rac)-CGP 52547), an antifungal antibiotic, is a thiazoline iron chelator. Dihydroaeruginoic acid is the condensation product of salicylate and one cysteine residue. Dihydroaeruginoic acid chelates Fe(III), inhibits DNA replication via ribonucleotide reductase, induces G1/S cell cycle block, reduces leukemia cell clonogenic viability. Dihydroaeruginoic acid inhibits phytopathogenic fungi and bacteria, suppresses Candida albicans development, and inhibits Agrobacterium tumefaciens biofilm formation via extracellular iron sequestration. Dihydroaeruginoic acid can be used for the research of phytopathogenic fungal and bacterial infections, and leukemia.

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Dihydroaeruginoic acid

Dihydroaeruginoic acid 構造式

CAS 番号 : 49608-51-7

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Dihydroaeruginoic acid 関連抗体

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製品説明

Dihydroaeruginoic acid ((Rac)-CGP 52547), an antifungal antibiotic, is a thiazoline iron chelator. Dihydroaeruginoic acid is the condensation product of salicylate and one cysteine residue. Dihydroaeruginoic acid chelates Fe(III), inhibits DNA replication via ribonucleotide reductase, induces G1/S cell cycle block, reduces leukemia cell clonogenic viability. Dihydroaeruginoic acid inhibits phytopathogenic fungi and bacteria, suppresses Candida albicans development, and inhibits Agrobacterium tumefaciens biofilm formation via extracellular iron sequestration. Dihydroaeruginoic acid can be used for the research of phytopathogenic fungal and bacterial infections, and leukemia[1][2][3][4].

Cellular Effect
Cell Line Type Value Description References
L1210 IC50
25 μM
Compound: 2
Antiproliferative activity of compound expressed as concentration that inhibits 50% of growth of L1210 leukemic cell suspension from 24 to 48 h after compound addition
Antiproliferative activity of compound expressed as concentration that inhibits 50% of growth of L1210 leukemic cell suspension from 24 to 48 h after compound addition
[PMID: 2709372]
P388 IC50
17 μM
Compound: 2
Antiproliferative activity of compound expressed as concentration that inhibits 50% of growth of P388 leukemic cell suspension from 24 to 48 hr after compound addition
Antiproliferative activity of compound expressed as concentration that inhibits 50% of growth of P388 leukemic cell suspension from 24 to 48 hr after compound addition
[PMID: 2709372]
体外実験

Dihydroaeruginoic acid (Compound 2) (24-48 h) inhibits L1210 murine leukemia cell growth with an IC50 of 25 μM and P388 murine leukemia cell growth with an IC50 of 17 μM, and reduces L1210 cell clonogenic viability in a concentration-dependent manner[3].
Dihydroaeruginoic acid (24 h) inhibits A. tumefaciens biofilm formation via iron sequestration with an IC50 of 300 μM[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dihydroaeruginoic acid 関連抗体

Cell Proliferation Assay[3]

Cell Line: L1210 murine leukemia cells, P388 murine leukemia cells
Concentration: 0 μM, 50 μM, 100 μM, 200 μM
Incubation Time: 24 h, 48 h
Result: Inhibited L1210 cell growth by 50% at 25 μM and P388 cell growth by 50% at 17 μM. Maintained 92% viability in L1210 cells and 77% viability in P388 cells at 100 μM via trypan blue exclusion.
Showed 81% viability at 50 μM, 54% viability at 100 μM, and 42% viability at 200 μM in L1210 soft agar clonogenic assays.
分子量

223.25

分子式

C10H9NO3S
CAS 番号
SMILES

OC1=C(C=CC=C1)C2=NC(CS2)C(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Dihydroaeruginoic acid Related Classifications

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Keywords:

Dihydroaeruginoic acid49608-51-7(Rac)-CGP 52547AntibioticFungalBacterialPseudomonas aeruginosaaeruginolribonucleotide reductaseleukemia cellsPseudomonas fluorescensCandida albicansAgrobacterium tumefaciensmurine neoplasmsaeruginoic acidpyochelinInhibitorinhibitorinhibit

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