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  3. Antibiotic Fungal Bacterial
  4. Dihydroaeruginoic acid

Dihydroaeruginoic acid  (Synonyms: (Rac)-CGP 52547)

Cat. No.: HY-W718262
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Dihydroaeruginoic acid ((Rac)-CGP 52547), an antifungal antibiotic, is a thiazoline iron chelator. Dihydroaeruginoic acid is the condensation product of salicylate and one cysteine residue. Dihydroaeruginoic acid chelates Fe(III), inhibits DNA replication via ribonucleotide reductase, induces G1/S cell cycle block, reduces leukemia cell clonogenic viability. Dihydroaeruginoic acid inhibits phytopathogenic fungi and bacteria, suppresses Candida albicans development, and inhibits Agrobacterium tumefaciens biofilm formation via extracellular iron sequestration. Dihydroaeruginoic acid can be used for the research of phytopathogenic fungal and bacterial infections, and leukemia.

For research use only. We do not sell to patients.

Dihydroaeruginoic acid

Dihydroaeruginoic acid Chemical Structure

CAS No. : 49608-51-7

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Dihydroaeruginoic acid Related Antibodies

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Description

Dihydroaeruginoic acid ((Rac)-CGP 52547), an antifungal antibiotic, is a thiazoline iron chelator. Dihydroaeruginoic acid is the condensation product of salicylate and one cysteine residue. Dihydroaeruginoic acid chelates Fe(III), inhibits DNA replication via ribonucleotide reductase, induces G1/S cell cycle block, reduces leukemia cell clonogenic viability. Dihydroaeruginoic acid inhibits phytopathogenic fungi and bacteria, suppresses Candida albicans development, and inhibits Agrobacterium tumefaciens biofilm formation via extracellular iron sequestration. Dihydroaeruginoic acid can be used for the research of phytopathogenic fungal and bacterial infections, and leukemia[1][2][3][4].

In Vitro

Dihydroaeruginoic acid (Compound 2) (24-48 h) inhibits L1210 murine leukemia cell growth with an IC50 of 25 μM and P388 murine leukemia cell growth with an IC50 of 17 μM, and reduces L1210 cell clonogenic viability in a concentration-dependent manner[3].
Dihydroaeruginoic acid (24 h) inhibits A. tumefaciens biofilm formation via iron sequestration with an IC50 of 300 μM[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dihydroaeruginoic acid Related Antibodies

Cell Proliferation Assay[3]

Cell Line: L1210 murine leukemia cells, P388 murine leukemia cells
Concentration: 0 μM, 50 μM, 100 μM, 200 μM
Incubation Time: 24 h, 48 h
Result: Inhibited L1210 cell growth by 50% at 25 μM and P388 cell growth by 50% at 17 μM. Maintained 92% viability in L1210 cells and 77% viability in P388 cells at 100 μM via trypan blue exclusion.
Showed 81% viability at 50 μM, 54% viability at 100 μM, and 42% viability at 200 μM in L1210 soft agar clonogenic assays.
Molecular Weight

223.25

Formula

C10H9NO3S
CAS No.
SMILES

OC1=C(C=CC=C1)C2=NC(CS2)C(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dihydroaeruginoic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihydroaeruginoic acid49608-51-7(Rac)-CGP 52547AntibioticFungalBacterialPseudomonas aeruginosaaeruginolribonucleotide reductaseleukemia cellsPseudomonas fluorescensCandida albicansAgrobacterium tumefaciensmurine neoplasmsaeruginoic acidpyochelinInhibitorinhibitorinhibit

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