49608-51-7
Chemical Structure
Dihydroaeruginoic acid
Synonym(s): (Rac)-CGP 52547
- CAS No.: 49608-51-7
- Formula:C10H9NO3S
- Molecular Weight:223.25
InChIKey: CECDPVOEINSAQG-UHFFFAOYSA-N
SMILES: OC1=C(C=CC=C1)C2=NC(CS2)C(O)=O
Biological Activity: Dihydroaeruginoic acid ((Rac)-CGP 52547), an antifungal antibiotic, is a thiazoline iron chelator. Dihydroaeruginoic acid is the condensation product of salicylate and one cysteine residue. Dihydroaeruginoic acid chelates Fe(III), inhibits DNA replication via ribonucleotide reductase, induces G1/S cell cycle block, reduces leukemia cell clonogenic viability. Dihydroaeruginoic acid inhibits phytopathogenic fungi and bacteria, suppresses Candida albicans development, and inhibits Agrobacterium tumefaciens biofilm formation via extracellular iron sequestration. Dihydroaeruginoic acid can be used for the research of phytopathogenic fungal and bacterial infections, and leukemia[1][2][3][4].
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Dihydroaeruginoic acid | Dihydroaeruginoic acid ((Rac)-CGP 52547), an antifungal antibiotic, is a thiazoline iron chelator. Dihydroaeruginoic acid is the condensation product of salicylate and one cysteine residue. Dihydroaeruginoic acid chelates Fe(III), inhibits DNA replication via ribonucleotide reductase, induces G1/S cell cycle block, reduces leukemia cell clonogenic viability. Dihydroaeruginoic acid inhibits phytopathogenic fungi and bacteria, suppresses Candida albicans development, and inhibits Agrobacterium tumefaciens biofilm formation via extracellular iron sequestration. Dihydroaeruginoic acid can be used for the research of phytopathogenic fungal and bacterial infections, and leukemia. | |||||||||||||||||||||
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- [1]. Reimmann C, et al. Dihydroaeruginoic acid synthetase and pyochelin synthetase, products of the pchEF genes, are induced by extracellular pyochelin in Pseudomonas aeruginosa. Microbiology (Reading). 1998;144 ( Pt 11):3135-3148. [Content Brief]
- [2]. Serino L, et al. Biosynthesis of pyochelin and dihydroaeruginoic acid requires the iron-regulated pchDCBA operon in Pseudomonas aeruginosa. J Bacteriol. 1997;179(1):248-257. [Content Brief]
- [3]. Elliott GT, et al. In vitro antiproliferative activity of 4-substituted 2-(2-hydroxyphenyl)thiazolines on murine leukemia cells. J Med Chem. 1989;32(5):1039-1043. [Content Brief]
- [4]. Rayi S, et al. Interbacterial Biofilm Competition through a Suite of Secreted Metabolites. ACS Chem Biol. 2024;19(2):462-470. [Content Brief]
Keywords
