Antibacterial agent 343 

Antibacterial agent 343 (Compound 47) is an Antibacterial agent. Antibacterial agent 343 binds to the allosteric site of PBP2a to open its active site. Antibacterial agent 343 disrupts bacterial cell membranes, leading to protein leakage. Antibacterial agent 343 interacts with DNA and inhibits replication and transcription. Antibacterial agent 343 induces ROS accumulation. Antibacterial agent 343 exhibits antibacterial activity against MRSA, Staphylococcus aureus, and Enterococcus faecalis. Antibacterial agent 343 can be used for the research of methicillin-resistant Staphylococcus aureus infections^[1].

Antibacterial agent 343 exhibits antibacterial activity and potently inhibits MRSA, with an MIC₅₀ of 0.5 μg/mL^[1].
Antibacterial agent 343 (5-40 μg/mL; 24 h) exhibits low cytotoxicity against normal LO2 and BEAS-2B cells, with no significant reduction in cell viability observed even at concentrations up to 40 μg/mL after 24 h of treatment^[1].
Antibacterial agent 343 (0.25-1 μg/mL; 0-14 h) inhibits the growth of MRSA in a concentration-dependent manner^[1].
Antibacterial agent 343 (0.5-4 μg/mL) promotes concentration-dependent reactive oxygen species (ROS) accumulation in MRSA, and the ROS level increases to 2.5 times that of the control group at 1× MIC, thereby inducing oxidative stress^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

750.80

C₃₃H₃₄N₈O₉S₂

NC1=NC(/C(C(NC2C(N3C2SCC(CN4CCN(C5=CC=C6C7=C5C=CC=C7C(N(C(CO)CO)C6=O)=O)CC4)=C3C(O)=O)=O)=O)=N/OC)=CS1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang JX, et al. Novel naphthalimide-derived cephalosporins as potential multitargeting anti-MRSA candidates. Bioorg Chem. Published online April 19, 2026.