Phthalocyanine 

Phthalocyanine is a type of pigment and Photosensitizer. Upon irradiation, Phthalocyanine generates ROS or converts light energy into heat, inducing oxidative damage, cytotoxicity, and photodynamic killing of bacterial biofilms. Phthalocyanine produces chemiluminescence when oxidized. It can be used in studies related to cancer, bacterial infections, and photodynamic approaches^[1][2][3][4].

Phthalocyanine exhibits photodynamic cytotoxicity in unspecified cancer cells, with a light IC₅₀ of 0.55 μM, a singlet oxygen quantum yield of 0.57, and extremely low dark cytotoxicity (dark IC₅₀ >100 μM)^[1].
Phthalocyanine exerts photodynamic cytotoxicity against HUVEC, breast cancer cell lines MCF-7 and MDA-MB-231, with IC₅₀ values of 45.6 μM, 69.1 μM and 89.3 μM under light exposure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

514.54

C₃₂H₁₈N₈

574-93-6

Solid

Dark purple to black

[H]N1C2=C3C=CC=CC3=C1/N=C4C5=C(C(/N=C6C7=C(/C(N/6[H])=N/C8=N/C(C9=C8C=CC=C9)=N\2)C=CC=C7)=N/4)C=CC=C5

Room temperature in continental US; may vary elsewhere.

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Rennie CC, et al. Targeted cancer phototherapy using phthalocyanine-anticancer drug conjugates. Dalton transactions (Cambridge, England : 2003). 2022 Sep 13;51(35):13157-13175.  [Content Brief]

  [2]. Dahlen M A. The phthalocyanines a new class of synthetic pigments and dyes[J]. Industrial & Engineering Chemistry, 1939, 31(7): 839-847.

  [3]. Spesia MB, et al. Evolution of Phthalocyanine Structures as Photodynamic Agents for Bacteria Inactivation. Chem Rec. 2022 Apr;22(4):e202100292.  [Content Brief]

  [4]. Jiang Z, et al. Pharmaceutical development, composition and quantitative analysis of phthalocyanine as the photosensitizer for cancer photodynamic therapy. J Pharm Biomed Anal. 2014 Jan;87:98-104.  [Content Brief]