Antifungal agent 43 

Antifungal agent 43 (compound B05) is an antifungal agent. Antifungal agents 43 has antifungal activity by inhibiting biofilm formation. Antifungal agent 43 has low toxicity in human cancer cell lines^[1].

Antifungal agent 43 (compound B05; 0.25-128 μg/mL) has antifungal activity against fungi strains with MIC values of 1, 1, 4, 4, 8, and 8 μg/mL for C.alb(sc5314), C.zey, C.alb, C.par, C.gla, and C.kru, respectively^[1].
Antifungal agent 43 (0.25-128 μg/mL) has antifungal activity against azole-resistant strains with MIC values of 2, 4, 4, 4, and 32 μg/mL for strain CaR, strain 632, strain 901, strain 904, and strain 17#, respectively^[1].
Antifungal agent 43 (0-10 μM) has low toxicity in human cancer cell lines with IC₅₀ values of 5.04, 7.43 and 14.74 for MDA-MB-231, PC-3, and HL-60 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

528.41

C₂₄H₂₆N₄Se₂

CC1=CC=C(C([Se][Se]C(C2=CC=C(C)C=C2)CN3C=CN=C3)CN4C=CN=C4)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xu H, et, al. Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51. Eur J Med Chem. 2022 Aug 28;243:114707.  [Content Brief]