Quorum sensing-IN-11

Cat. No.: HY-181760: Data Sheet Handling Instructions
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Quorum sensing-IN-11 is a quorum sensining inhibitor and a LasR antagonist with an IC₅₀ of 0.7399 μM. Quorum sensing-IN-11 inhibits biofilm, pyocyanin formation and swimming motility in Pseudomonas aeruginosa. Quorum sensing-IN-11 can be used for the research of Pseudomonas aeruginosa infection.

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Quorum sensing-IN-11 Chemical Structure

CAS No. : 780790-69-4

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Description	Quorum sensing-IN-11 is a quorum sensining inhibitor and a LasR antagonist with an IC₅₀ of 0.7399 μM. Quorum sensing-IN-11 inhibits biofilm, pyocyanin formation and swimming motility in Pseudomonas aeruginosa. Quorum sensing-IN-11 can be used for the research of Pseudomonas aeruginosa infection^[1].
In Vitro	Quorum sensing-IN-11 (Compound 7f) (24 h) inhibits biofilm, pyocyanin formation and swimming motility in Pseudomonas aeruginosa by 83, 76, 90%^[1]. Quorum sensing-IN-11 (0.1-10 μM; 4 h) potently inhibits LasR in the β-galactosidase reporter assay with an IC₅₀ of 0.7399 ± 0.005 μM^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Quorum sensing-IN-11 Related Antibodies
Molecular Weight	366.21
Formula	C₁₈H₁₂BrN₃O
CAS No.	780790-69-4
SMILES	BrC(C=C1)=CC=C1C(/C=C/C(C#N)=C2NC3=CC=CC=C3N/2)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (266 KB) Handling Instructions (2659 KB)
References	[1]. Mohammed E Z, et al. Design, regioselective, time gated synthesis of novel benzo [d] imidazole analogues as potential quorum sensing inhibitors targeting LasR in Pseudomonas aeruginosa[J]. Bioorganic Chemistry, 2026: 109561. [Content Brief]