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Dipeptide

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (57) Cardiovascular Disease (30) Endocrinology (4) Infection (37) Inflammation/Immunology (47) Metabolic Disease (38) Neurological Disease (47)
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Oligonucleotides:	Pegylated Lipids (1) Sweetening Agents (1)

327

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

188

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Antibodies

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Oligonucleotides

Muramyl dipeptide 5+ Cited Publications MDP	p38 MAPK NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist .

Aspartame 1 Publications Verification SC-18862	Environmental Pollutants Biochemical Assay Reagents	Neurological Disease
Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

Cyclo(L-Phe-L-Pro)	Fungal Bacterial IFNAR Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

L-Alanyl-L-glutamine 1 Publications Verification	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations .

Mifamurtide 5 Publications Verification MTP-PE; L-MTP-PE; CGP 19835	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Mifamurtide (MTP-PE), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide is a specific ligand for NOD2 and acts as an insulin sensitizer. Mifamurtide has potential for use in rare disease and osteosarcoma research .

Cyclo(L-Leu-L-Pro) Cyclo(L-prolyl-L-leucyl)	Fungal Bacterial Influenza Virus	Infection
Cyclo(L-Leu-L-Pro) is a cyclic dipeptide with broad-spectrum antibacterial, antiviral and antifungal activities. Its biological activity is highly dependent on the stereoconfiguration and is widely present in microbial metabolites. Cyclo(L-Leu-L-Pro) efficiently and specifically inhibits the production of aflatoxin by Aspergillus flavus. The cis configuration of Cyclo(L-Leu-L-Pro) (cis-cyclo(L-Leu-L-Pro)) has broad-spectrum antibacterial activity against multi-drug resistant bacteria and significantly inhibits the influenza A virus H3N2 .

Glycyl-L-proline H-Gly-Pro-OH; Gly-Pro	Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Glycyl-L-proline (H-Gly-Pro-OH) is a dipeptide. Glycyl-L-proline can induce MCF-7 cells apoptosis. Glycyl-L-proline can enhance the inhibitory effect of the PRODH/POX knockout on collagen and DNA biosynthesis. Glycyl-L-proline can inhibit Gly-Sar and L-proline transport. Glycyl-L-proline can be used for the researches of cancer and metabolic disease, such as breast cancer .

Dipeptide diaminobutyroyl benzylamide diacetate	nAChR	Neurological Disease Metabolic Disease
Dipeptide diaminobutyroyl benzylamide diacetate, a Wagerlin-1-mimicking peptide, is a nAChR antagonist. Dipeptide diaminobutyroyl benzylamide diacetate mimics Waglerin-1 to block neuromuscular junction nicotinic acetylcholine receptors, partially inhibits neuronal signal transduction, and relaxes muscles. Dipeptide diaminobutyroyl benzylamide diacetate reduces appearance of facial wrinkles linked to repeated muscle movement.Dipeptide diaminobutyroyl benzylamide diacetate can be used for the research of mild-to-moderate fine and coarse periocular and perioral wrinkles and periorbital ageing .

Leu-Leu-OH L-Leucyl-L-leucine; Leu-Leu; H-Leu-Leu-OH	Amino Acid Derivatives	Metabolic Disease
Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

H-Val-Ala-OH 1 Publications Verification Valyl-alanine	Endogenous Metabolite Amino Acid Derivatives	Metabolic Disease
H-Val-Ala-OH (Valyl-alanine) is a dipeptide formed from L-Valine and L-Alanine residues. H-Val-Ala-OH has a role as a metabolite and also has a bitter taste .

Glycyl-L-tyrosine Glycyltyrosine; Gly-Tyr; H-Gly-Tyr-OH	Amino Acid Derivatives	Others
Glycyl-L-tyrosine is a synthetic dipeptide that can be used as a food additive for tyrosine supplementation .

gamma-Glutamylisoleucine γ-Glu-Ile; H-γ-Glu-Ile-OH	Amino Acid Derivatives	Others
gamma-Glutamylisoleucine (γ-Glu-Ile; H-γ-Glu-Ile-OH) is a dipeptide composed of γ-glutamic acid and isoleucine, and it is also a degradation product of macromolecular proteins after proteolysis .

H-Met-Met-OH L-Methionyl-L-methionine	Amino Acid Derivatives	Others
H-Met-Met-OH (L-Methionyl-L-methionine) is a dipeptide composed of two methionine residues. H-Met-Met-OH is a dietary supplement that has been shown to have various health benefits in animals. H-Met-Met-OH is orally active .

Ala-Ser H-Ala-Ser-OH	Amino Acid Derivatives	Others
Ala-Ser (H-Ala-Ser-OH) is a dipeptide composed of two amino acids linked by a peptide bond .

H-Ile-Trp-OH Ile-Trp	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Ile-Trp-OH (Ile-Trp), a dipeptide, is an angiotensin-converting enzyme (ACE) inhibitor with an IC₅₀ of 0.7 μM. H-Ile-Trp-OH inhibits predominantly the C-domain of ACE .

N-Acetylcarnosine N-Acetyl-L-carnosine	Drug Intermediate Endogenous Metabolite	Inflammation/Immunology
N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic agent in human cataracts .

L-gamma-Glutamyl-L-threonine gamma-Glutamylthreonine; H-γ-Glu-Thr-OH; γ-Glu-Thr	Bacterial Peptide-Drug Conjugates (PDCs) Drug Metabolite	Infection Inflammation/Immunology
L-gamma-Glutamyl-L-threonine (gamma-Glutamylthreonine; H-γ-Glu-Thr-OH; γ-Glu-Thr) is a dipeptide obtained through the formal condensation of the L-glutamic acid side chain carboxyl group and the L-threonine amino group. L-gamma-Glutamyl-L-threonine is present in high concentrations in human urine and exhibits antibacterial activity against Gram-negative bacterial. L-gamma-Glutamyl-L-threonine is also a flavor compound. Gamma-Glutamylthreonine is a metabolite catalyzed by γ-glutamyl transpeptidase and is associated with immune regulation. Gamma-Glutamylthreonine can be used in research on inflammation and bacterial infections .

Cyclo(his-pro) Cyclohistidyl-proline; Histidylproline diketopiperazine	NF-κB Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .

Dipeptide 2 N-Valyltryptophan; Val-Trp	Angiotensin-converting Enzyme (ACE) Calcium Channel NO Synthase	Cardiovascular Disease
Dipeptide 2 (N-Valyltryptophan) is an orally active, competitive angiotensin-converting enzyme (ACE) inhibitory peptide with an IC₅₀ of 10.50 μM. Dipeptide 2 reduces intracellular Calcium ions. Dipeptide 2 significantly increases the content of NO, inhibits the production of ET-1, and induces the phosphorylation of eNOS. Dipeptide 2 decreases the systolic and diastolic blood pressure of spontaneously hypertensive rats .

H-Tyr-Ala-OH Tyr-Ala	Amino Acid Derivatives Drug Intermediate	Others
H-Tyr-Ala-OH (Tyr-Ala) is a dipeptide containing tyrosine and alanine .

L-Tryptophanylglycine	Endogenous Metabolite	Metabolic Disease
L-Tryptophanylglycine is a dipeptide. L-Tryptophanylglycine exerts its function through competitive substrate interaction with intestinal dipeptide transporters .

Valylhistidine	Biochemical Assay Reagents	Others
Valylhistidine is a dipeptide composed of valine and histidine (Val-His). Valylhistidine can form a dipeptide complex with Cu (II) that mimics superoxide dismutase but lacks activity .

Z-Ala-Ala-OH	Amino Acid Derivatives	Others
Z-Ala-Ala-OH is an N-benzyloxycarbonyl (Z) dipeptide containing small nonpolar amino acids. Z-Ala-Ala-OH is used for enzymatic peptide synthesis .

Glycyl-L-valine	Biochemical Assay Reagents	Others
Glycyl-L-valine is an organic dipeptide composed of glycine and L-valine .

L-Leucyl-L-alanine	Endogenous Metabolite	Metabolic Disease
L-Leucyl-L-alanine is a simple aliphatic dipeptide composed of L-leucine and L-alanine .

Prolylisoleucine	Prolyl Endopeptidase (PREP)	Others
Prolylisoleucine (Pro-Ile) is a dipeptide composed of Proline and Isoleucine, as well as a blocker of endopeptidase 24.16 .

Homocarnosine L-Homocarnosine	GABA Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects .Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

Cyclo(his-pro) TFA Cyclohistidyl-proline TFA; Histidylproline diketopiperazine TFA	NF-κB Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .

Leucyl-phenylalanine	Endogenous Metabolite	Others
Leucyl-phenylalanine belongs to the class of organic compounds known as dipeptides.

Lysylcysteine L-Lysyl-L-cysteine; Lys-Cys; H-Lys-Cys-OH	Amino Acid Derivatives	Others
Lysylcysteine (L-Lysyl-L-cysteine) is a dipeptide composed of lysine and cysteine.

Aspartame (Standard) SC-18862 (Standard)	Biochemical Assay Reagents Reference Standards	Neurological Disease
Aspartame (Standard) is the analytical standard of Aspartame. This product is intended for research and analytical applications. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

Mifamurtide sodium 5 Publications Verification MTP-PE sodium; L-MTP-PE sodium; CGP 19835 sodium	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Mifamurtide sodium (MTP-PE sodium), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide sodium is a specific ligand for NOD2 and acts as an insulin sensitizer. Mifamurtide sodium has potential for use in rare disease and osteosarcoma research .

Mifamurtide TFA 5 Publications Verification MTP-PE TFA; L-MTP-PE TFA; CGP 19835 TFA	NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Mifamurtide TFA (MTP-PE TFA), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide TFA is a specific ligand for NOD2 and acts as an insulin sensitizer. Mifamurtide TFA has potential for use in rare disease and osteosarcoma research .

Lysylcysteine TFA L-Lysyl-L-cysteine TFA; Lys-Cys TFA; H-Lys-Cys-OH TFA	Amino Acid Derivatives	Others
Lysylcysteine (L-Lysyl-L-cysteine) TFA is a dipeptide composed of lysine and cysteine .

L-Phenylalanyl-L-threonine Phe-Thr; H-Phe-Thr-OH	Amino Acid Derivatives	Others
L-Phenylalanyl-L-threonine is a dipeptide containing Phenylalanine and threonine. L-Phenylalanyl-L-threonine can be used to synthesize the cyclic hexapeptide Banyascyclamide A .

Prolidase	Aminopeptidase	Others
Prolidase is a metallo-dependent hydrolase. Prolidase is a metal-dependent peptidase specialized in the cleavage of dipeptides containing proline or hydroxyproline on their C-termini .

L-Isoleucyl-L-valine Ile-Val	Ser/Thr Protease	Cancer
L-Isoleucyl-L-valine (Ile-Val) is a dipeptide that induces the bovine trypsinogen-trypsin transition .

H-Asn-Arg-OH diTFA Asn-Arg diTFA	Drug Intermediate	Others
H-Asn-Arg-OH diTFA is a dipeptide formed by the connection of asparagine and arginine via a peptide bond, which can be used in polypeptide synthesis.

Lys-Phe H-Lys-Phe-OH	Amino Acid Derivatives	Cardiovascular Disease
Lys-Phe is a dipeptide that inhibits both cell sickling and the gelation of solutions of sickle-cell haemoglobin .

Z-Arg-Arg-βNA acetate	Cathepsin	Others
Z-Arg-Arg-βNA acetate is a sensitive dipeptide substrate of the protease Cathepsin B and resistant to proteases H and L. Z-Arg-Arg-βNA acetate can serve as an important tool for distinguishing non-Cathepsin B type proteins .

JBP485 cyclo(L-Hyp-L-Ser)	Endogenous Metabolite	Others
JBP485 (cyclo-trans-4-L-hydroxyprolyl-L-serine) is a dipeptide with anti-hepatotoxic and wound healing properties. JBP485 can be used for research of various kinds of corneal epithelial diseases .

WYneN	Biochemical Assay Reagents	Inflammation/Immunology
WYneN (compound 10) is a functionalized Wittig-alkyne probe. WYneN exhibits strong reactivity with sulfinic acid dipeptide models, similar to the parent Wittig reagent. WYneN can be used to reveal the function of oxidative modifications on a proteome-wide scale .

Cyclo(L-leucyl-L-tryptophyl) Cyclo(Leu-Trp)	Bacterial Fungal Melatonin Receptor	Infection Neurological Disease
Cyclo(L-leucyl-L-tryptophyl) (Cyclo(-Leu-Trp)) is a cyclic dipeptide that inhibits a various of bacteria and fungi. Cyclo(L-leucyl-L-tryptophyl) is a melatonin receptor agonist and is also used as a bitter ligand .

EDA-DA TFA	Bacterial	Infection
EDA-DA is a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. EDA-DA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

Fmoc-Ile-Ser(psi(Me,Me)pro)-OH	Amino Acid Derivatives	Others
Fmoc-Ile-Ser(psi(Me,Me)pro)-OH is a dipeptide.

DB02307	Others	Others
DB02307 is a dipeptide that contains a sequence of two alpha-amino acids joined by a peptide bond .

Cat. No.	상품명

HY-L255

Dipeptide Compound Library

80 compounds

Dipeptide compounds have attracted extensive attention in drug discovery and life science research due to their simple structures, ease of modification, and favorable biocompatibility. As small peptides composed of two amino acids, dipeptides exhibit diverse biological activities, including anti-inflammatory, antioxidant, antimicrobial, anticancer, and immunomodulatory effects, showing significant application potential in metabolic disorders, neurological diseases, and cancer research. Compared with traditional small molecules, dipeptide compounds possess favorable target-binding properties and high structural plasticity, making them valuable tools for drug screening and mechanism studies.

The MCE Dipeptide Compound Library contains 80 dipeptide compounds and can be applied to peptide drug discovery and development.

Cat. No.	상품명	Type

HY-164729

FZ-AD005

Fluorescent Dyes

FZ-AD005 is a DLL3-targeting antibody-drug conjugate (ADC) with high selectivity, composed of the anti-DLL3 antibody FZ-A038 (HY-P990896), a dipeptide linker (Val-Ala), and DXd (HY-13631D). The K_d value of FZ-AD005 for human DLL3 ranges from 13.29 to 58.3 pmol/L. After binding to DLL3 on the cell surface, FZ-AD005 mediates endocytosis, and the payload DXd is released via cleavage by lysosomal cathepsins. DXd inhibits topoisomerase TopI to induce double-strand DNA breaks, cell cycle arrest and apoptosis, and FZ-AD005 exhibits bystander killing activity against adjacent DLL3-negative cells. FZ-AD005 shows stable circulation in vivo, has good tolerance and acceptable pharmacokinetic profiles in rats and cynomolgus monkeys, and effectively inhibits the growth of DLL3-expressing tumor cells. FZ-AD005 serves as a promising candidate molecule for research on small cell lung cancer and human neuroendocrine prostate cancer .

HY-D2575

WYneN	Fluorescent Dyes
WYneN (compound 10) is a functionalized Wittig-alkyne probe. WYneN exhibits strong reactivity with sulfinic acid dipeptide models, similar to the parent Wittig reagent. WYneN can be used to reveal the function of oxidative modifications on a proteome-wide scale .

Cat. No.	상품명	Type

HY-W010162

H-Ala-Ala-OH L-Alanyl-L-alanine; Ala-Ala	Biochemical Assay Reagents
H-Ala-Ala-OH is a substrate of human intestinal oligopeptide transporter (PEPT1/SLC15A1), with an IC₅₀ of 0.25 mM and an EC₅₀ of 0.08 mM against human *PEPT1. When used as a dipeptide* linker in antibody-drug conjugates (ADCs) loaded with glucocorticoid receptor regulator payloads, H-Ala-Ala-OH enables efficient intracellular payload release .

HY-143686

ImmTher	Biochemical Assay Reagents
ImmTher is a liposome-encapsulated lipophilic disaccharide tripeptide derivative of muramyl dipeptide. ImmTher can up-regulate specific monocyte cytokine genes and activate monocyte-mediated tumoricidal activity .

HY-W010162R

H-Ala-Ala-OH (Standard)

L-Alanyl-L-alanine (Standard); Ala-Ala (Standard)

Biochemical Assay Reagents

H-Ala-Ala-OH (L-Alanyl-L-alanine; Ala-Ala) (Standard) is the analytical standard of H-Ala-Ala-OH (L-Alanyl-L-alanine; Ala-Ala). This product is intended for research and analytical applications. H-Ala-Ala-OH (L-Alanyl-L-alanine; Ala-Ala) is a nonpolar dipeptide that is absorbed by human intestinal Caco-2 cells. The transport of alanine (Ala), like proton/amino acid symport, can lead to cytoplasmic acidification .

Cat. No.	상품명	Target	Research Area

HY-B0361

Aspartame 1 Publications Verification SC-18862	Environmental Pollutants Biochemical Assay Reagents	Neurological Disease
Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

HY-P1934A

Cyclo(L-Phe-L-Pro)	Fungal Bacterial IFNAR Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

HY-W014102

L-Alanyl-L-glutamine 1 Publications Verification	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations .

HY-P1939

Cyclo(L-Leu-L-Pro) Cyclo(L-prolyl-L-leucyl)	Fungal Bacterial Influenza Virus	Infection
Cyclo(L-Leu-L-Pro) is a cyclic dipeptide with broad-spectrum antibacterial, antiviral and antifungal activities. Its biological activity is highly dependent on the stereoconfiguration and is widely present in microbial metabolites. Cyclo(L-Leu-L-Pro) efficiently and specifically inhibits the production of aflatoxin by Aspergillus flavus. The cis configuration of Cyclo(L-Leu-L-Pro) (cis-cyclo(L-Leu-L-Pro)) has broad-spectrum antibacterial activity against multi-drug resistant bacteria and significantly inhibits the influenza A virus H3N2 .

HY-W016887

Glycyl-L-proline H-Gly-Pro-OH; Gly-Pro	Endogenous Metabolite Apoptosis	Metabolic Disease Cancer
Glycyl-L-proline (H-Gly-Pro-OH) is a dipeptide. Glycyl-L-proline can induce MCF-7 cells apoptosis. Glycyl-L-proline can enhance the inhibitory effect of the PRODH/POX knockout on collagen and DNA biosynthesis. Glycyl-L-proline can inhibit Gly-Sar and L-proline transport. Glycyl-L-proline can be used for the researches of cancer and metabolic disease, such as breast cancer .

HY-P0102

Dipeptide diaminobutyroyl benzylamide diacetate	nAChR	Neurological Disease Metabolic Disease
Dipeptide diaminobutyroyl benzylamide diacetate, a Wagerlin-1-mimicking peptide, is a nAChR antagonist. Dipeptide diaminobutyroyl benzylamide diacetate mimics Waglerin-1 to block neuromuscular junction nicotinic acetylcholine receptors, partially inhibits neuronal signal transduction, and relaxes muscles. Dipeptide diaminobutyroyl benzylamide diacetate reduces appearance of facial wrinkles linked to repeated muscle movement.Dipeptide diaminobutyroyl benzylamide diacetate can be used for the research of mild-to-moderate fine and coarse periocular and perioral wrinkles and periorbital ageing .

HY-W008642

Leu-Leu-OH L-Leucyl-L-leucine; Leu-Leu; H-Leu-Leu-OH	Amino Acid Derivatives	Metabolic Disease
Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs .

HY-W009592

Glycyl-L-tyrosine Glycyltyrosine; Gly-Tyr; H-Gly-Tyr-OH	Amino Acid Derivatives	Others
Glycyl-L-tyrosine is a synthetic dipeptide that can be used as a food additive for tyrosine supplementation .

HY-W724905

gamma-Glutamylisoleucine γ-Glu-Ile; H-γ-Glu-Ile-OH	Amino Acid Derivatives	Others
gamma-Glutamylisoleucine (γ-Glu-Ile; H-γ-Glu-Ile-OH) is a dipeptide composed of γ-glutamic acid and isoleucine, and it is also a degradation product of macromolecular proteins after proteolysis .

HY-P4244

Ala-Ser H-Ala-Ser-OH	Amino Acid Derivatives	Others
Ala-Ser (H-Ala-Ser-OH) is a dipeptide composed of two amino acids linked by a peptide bond .

HY-133026

N-Acetylcarnosine N-Acetyl-L-carnosine	Drug Intermediate Endogenous Metabolite	Inflammation/Immunology
N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic agent in human cataracts .

HY-N13356

L-gamma-Glutamyl-L-threonine gamma-Glutamylthreonine; H-γ-Glu-Thr-OH; γ-Glu-Thr	Bacterial Peptide-Drug Conjugates (PDCs) Drug Metabolite	Infection Inflammation/Immunology
L-gamma-Glutamyl-L-threonine (gamma-Glutamylthreonine; H-γ-Glu-Thr-OH; γ-Glu-Thr) is a dipeptide obtained through the formal condensation of the L-glutamic acid side chain carboxyl group and the L-threonine amino group. L-gamma-Glutamyl-L-threonine is present in high concentrations in human urine and exhibits antibacterial activity against Gram-negative bacterial. L-gamma-Glutamyl-L-threonine is also a flavor compound. Gamma-Glutamylthreonine is a metabolite catalyzed by γ-glutamyl transpeptidase and is associated with immune regulation. Gamma-Glutamylthreonine can be used in research on inflammation and bacterial infections .

HY-101402

Cyclo(his-pro) Cyclohistidyl-proline; Histidylproline diketopiperazine	NF-κB Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .

HY-118060

Dipeptide 2 N-Valyltryptophan; Val-Trp	Angiotensin-converting Enzyme (ACE) Calcium Channel NO Synthase	Cardiovascular Disease
Dipeptide 2 (N-Valyltryptophan) is an orally active, competitive angiotensin-converting enzyme (ACE) inhibitory peptide with an IC₅₀ of 10.50 μM. Dipeptide 2 reduces intracellular Calcium ions. Dipeptide 2 significantly increases the content of NO, inhibits the production of ET-1, and induces the phosphorylation of eNOS. Dipeptide 2 decreases the systolic and diastolic blood pressure of spontaneously hypertensive rats .

HY-111659

His-Pro Histidyl-proline; H-His-Pro-OH	Peptides	Others
His-Pro (Histidyl-proline) is a dipeptide consisting of histidyl and proline .

HY-P4666

Valylhistidine	Biochemical Assay Reagents	Others
Valylhistidine is a dipeptide composed of valine and histidine (Val-His). Valylhistidine can form a dipeptide complex with Cu (II) that mimics superoxide dismutase but lacks activity .

HY-P2389

Fmoc-Lys(Boc)-Ser(psi(Me,Me)pro)-OH	Amino Acid Derivatives	Others
Fmoc-Lys(Boc)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

HY-16959

*CEP dipeptide* 1** 1 Publications Verification	Peptides	Others
CEP dipeptide 1 is a CEP dipeptide with potent angiogenic activity; mediators of age-related macular degeneration (AMD).

HY-128434

L-Leucyl-L-alanine	Endogenous Metabolite	Metabolic Disease
L-Leucyl-L-alanine is a simple aliphatic dipeptide composed of L-leucine and L-alanine .

HY-114883

Homocarnosine L-Homocarnosine	GABA Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects .Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .

HY-101402A

Cyclo(his-pro) TFA Cyclohistidyl-proline TFA; Histidylproline diketopiperazine TFA	NF-κB Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .

HY-114788

Lysylcysteine L-Lysyl-L-cysteine; Lys-Cys; H-Lys-Cys-OH	Amino Acid Derivatives	Others
Lysylcysteine (L-Lysyl-L-cysteine) is a dipeptide composed of lysine and cysteine.

HY-P2407

Fmoc-Ser(tBu)-Ser(psi(Me,Me)pro)-OH	Amino Acid Derivatives	Others
Fmoc-Ser(tBu)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

HY-P4280

Arg-Tyr H-Arg-Tyr-OH	Reactive Oxygen Species (ROS)	Others
Arg-Tyr is a dipeptide which has strong hydroxyl-radical and hydrogen-peroxide scavenging activity .

HY-134017

*Acetyl dipeptide-1 cetyl ester* Calmosensine	Peptides	Others
Acetyl dipeptide-1 cetyl ester (Calmosensine) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .

HY-139468

H-Ala-Glu-OH Ala-Glu-OH; Ala-Glu	Peptides	Others
Ala-Glu-OH is an agent of the dipeptide .

HY-B0361R

Aspartame (Standard) SC-18862 (Standard)	Biochemical Assay Reagents Reference Standards	Neurological Disease
Aspartame (Standard) is the analytical standard of Aspartame. This product is intended for research and analytical applications. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

HY-135158

Prolylvaline Val-Pro; H-Val-Pro-OH	Peptides	Others
Prolylvaline (Pro-Val) is a proline-valine dipeptide that can be used to bind fluorescein isothiocyanate (FITC). Prolylvaline has specific imprinting effects in Tetrahymena, inducing negative imprinting. Using protozoan organisms, proline dipeptides containing different partner amino acids can be distinguished from dipeptides with opposite amino acid positions .

HY-131115

Cyclo(Tyr-Leu)	Peptides	Others
Cyclo(Tyr-Leu) is a cyclic dipeptide .

HY-W009592A

Glycyl-L-tyrosine dihydrate Glycyltyrosine dihydrate; Gly-Tyr dihydrate; H-Gly-Tyr-OH dihydrate	Amino Acid Derivatives	Others
Glycyl-L-tyrosine dihydrate is a synthetic dipeptide that can be used as a food additive for tyrosine supplementation .

HY-114788A

Lysylcysteine TFA L-Lysyl-L-cysteine TFA; Lys-Cys TFA; H-Lys-Cys-OH TFA	Amino Acid Derivatives	Others
Lysylcysteine (L-Lysyl-L-cysteine) TFA is a dipeptide composed of lysine and cysteine .

HY-W967223

L-Phenylalanyl-L-threonine Phe-Thr; H-Phe-Thr-OH	Amino Acid Derivatives	Others
L-Phenylalanyl-L-threonine is a dipeptide containing Phenylalanine and threonine. L-Phenylalanyl-L-threonine can be used to synthesize the cyclic hexapeptide Banyascyclamide A .

HY-131092A

H-Asn-Arg-OH diTFA Asn-Arg diTFA	Drug Intermediate	Others
H-Asn-Arg-OH diTFA is a dipeptide formed by the connection of asparagine and arginine via a peptide bond, which can be used in polypeptide synthesis.

HY-135514

Lys-Phe H-Lys-Phe-OH	Amino Acid Derivatives	Cardiovascular Disease
Lys-Phe is a dipeptide that inhibits both cell sickling and the gelation of solutions of sickle-cell haemoglobin .

HY-158307

Z-Arg-Arg-βNA acetate	Cathepsin	Others
Z-Arg-Arg-βNA acetate is a sensitive dipeptide substrate of the protease Cathepsin B and resistant to proteases H and L. Z-Arg-Arg-βNA acetate can serve as an important tool for distinguishing non-Cathepsin B type proteins .

HY-P2092

Cyclo(L-leucyl-L-tryptophyl) Cyclo(Leu-Trp)	Bacterial Fungal Melatonin Receptor	Infection Neurological Disease
Cyclo(L-leucyl-L-tryptophyl) (Cyclo(-Leu-Trp)) is a cyclic dipeptide that inhibits a various of bacteria and fungi. Cyclo(L-leucyl-L-tryptophyl) is a melatonin receptor agonist and is also used as a bitter ligand .

HY-P4274

Arginylmethionine	Peptides	Others
Arginylmethionine is a dipeptide composed of arginine and methionine.

HY-131109

Cyclo(Gly-Tyr) 1 Publications Verification	Peptides	Others
Cyclo(Gly-Tyr) is a cyclic dipeptide .

HY-131111

Cyclo(Gly-Gln)	Peptides	Others
Cyclo(Gly-Gln) is a cyclic dipeptide .

HY-P4252

Arginylaspartic acid	Peptides	Others
Arginylaspartic acid is a dipeptide composed of arginine and aspartic acid .

HY-P4645

Mca-Pro-Leu-OH Mca-Pro-Leu	Peptides	Others
Mca-Pro-Leu is a fluorescently labeled dipeptide .

HY-P2410

Fmoc-Ile-Ser(psi(Me,Me)pro)-OH	Amino Acid Derivatives	Others
Fmoc-Ile-Ser(psi(Me,Me)pro)-OH is a dipeptide.

HY-W336442

H-His-Ala-OH L-histidyl-L-alanine	Biochemical Assay Reagents	Others
H-His-Ala-OH is a dipeptide -type substrate that can be utilized in biochemical assay .

HY-P5036

Cyclo(D-Trp-Tyr)	Peptides	Others
Cyclo(D-Trp-Tyr) is aCyclic dipeptide.

HY-P4483

H-Pro-Arg-OH	Peptides	Others
H-Pro-Arg-OH is a dipeptide composed of proline and arginine.

HY-P2398

Fmoc-Phe-Ser(psi(Me,Me)pro)-OH	Amino Acid Derivatives	Others
Fmoc-Phe-Ser(psi(Me,Me)pro)-OH is a dipeptide.

HY-P2390

Fmoc-Leu-Ser(psi(Me,Me)pro)-OH	Amino Acid Derivatives	Others
Fmoc-Leu-Ser(psi(Me,Me)pro)-OH is a dipeptide.

HY-W014786

DL-Alanyl-DL-leucine	Amino Acid Derivatives	Others
DL-Alanyl-DL-leucine is a dipeptide compound composed of alanine and leucine .

HY-P2399

Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH	Amino Acid Derivatives	Others
Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH is a dipeptide.

HY-P2391

Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OH	Amino Acid Derivatives	Others
Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OH is a dipeptide.

Cat. No.	상품명

HY-K1046P

L-Alanyl-L-Glutamine (100×)
MCE L-Alanyl-L-Glutamine (100×) contains 200 mM L-alanyl-L-glutamine and is formulated in 0.85% NaCl. It serves as a stable dipeptide substitute for L-glutamine. Compared with free L-glutamine, it exhibits superior stability and significantly reduces the accumulation of toxic ammonia during culture, thereby improving cell viability and growth performance.

Cat. No.	상품명	Target	Research Area	Image

HY-P99682

Ladiratuzumab hLIV22	ADC Antibody	Cancer
Ladiratuzumab (hLIV22) is a humanized monoclonal antibody against zinc transporter LIV-1/ZIP6. Ladiratuzumab is conjugated to MMAE (HY-15162) via a cleavable dipeptide linker to synthesize an antibody-drug conjugate (ADC) Ladiratuzumab vedotin (HY-P99683). Ladiratuzumab vedotin selectively targets LIV-1 protein overexpressed on the surface of tumor cells, enters cells through antibody-mediated receptor endocytosis, releases MMAE to inhibit microtubule polymerization, and kills adjacent tumor cells with a bystander effect. Ladiratuzumab can be used in the study of solid tumors such as metastatic triple-negative breast cancer (mTNBC) .

HY-P99238

Rolinsatamab	ADC Antibody	Inflammation/Immunology Cancer
Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .

HY-141599

Camidanlumab tesirine ADCT 301	Antibody-Drug Conjugates (ADCs) Interleukin Related	Cancer
Camidanlumab tesirine (ADCT 301) is an ADC comprising HuMax-TAC, a human IgG1 mAb directed against human CD25, stochastically conjugated through a dipeptide cleavable linker to a pyrrolobenzodiazepine (PBD) dimer warhead. Camidanlumab tesirine has a drug–antibody ratio (DAR) of 2.3. Camidanlumab tesirine binds human CD25 with picomolar affinity. Camidanlumab tesirine has highly potent and selective cytotoxicity against a panel of CD25-expressing human lymphoma cell lines .

Host:	Mouse (2)
Reactivity:	human (2)
Application:	ICC/IF (1) IF-Tissue (1) IP (2) WB (2) ELISA (1)
Isotype:	IgG1 (1) IgG2b (1)
Conjugation:	Non-conjugated (2)
Modification:	Unmodified (2)

Cat. No.	Compare	상품명	Application	Reactivity	Image

HY-P89717

	GlcNAc kinase Antibody (YA9061) N-acetyl-D-glucosamine kinase, N-acetylglucosamine kinase, GlcNAc kinase, Muramyl Dipeptide kinase, N-acetyl-D-mannosamine kinase, NAGK	WB, ICC/IF, IF-Tissue, IP, ELISA	human
	GlcNAc kinase Antibody (YA9061) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GlcNAc kinase.

HY-P89564

	atrophin-2 Antibody (YA8908) ARG, ARP, ATN1L, KIAA0458, RERE, Arginine-glutamic acid Dipeptide repeats protein, Atrophin-1-like protein, Atrophin-1-related protein	WB, IP	human
	atrophin-2 Antibody (YA8908) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to atrophin-2.

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Cat. No.
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Reactivity
Application
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Immunogen
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Cat. No.	상품명		Classification

HY-172287

DBCO-PEG2-Val-Cit-PAB-MMAE		DBCO
DBCO-PEG2-Val-Cit-PAB-MMAE is an ADC linker featuring a DBCO group, a Val-Cit dipeptide, a PAB motif, and an MMAE warhead. The DBCO group is a click chemistry handle which readily reacts with azide groups, while the Val-Cit is a protease-cleavable dipeptide which releases the MMAE warhead into cells via an elimination mechanism.

HY-151859

N3-Gly-Gly-OH		Azide
N3-Gly-Gly-Gly-OH is a click chemistry reagent containing an azide group. N3-Gly-Gly-OH undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an alkyne group. N3-Gly-Gly-OH also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. N3-Gly-Gly-Gly-OH can be used to construct peptide-like ADC linkers via click chemistry .

HY-147097A

EDA-DA TFA		Alkynes
EDA-DA is a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. EDA-DA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-147097

EDA-DA		Alkynes
EDA-DA, a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure . EDA-DA is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	상품명		Classification

HY-B0361

Aspartame 1 Publications Verification SC-18862		Sweetening Agents
Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .

HY-W440807

Oleoyl-Gly-Lys-(m-PEG11)-NH2		Pegylated Lipids
Oleoyl-Gly-Lys-(m-PEG11)-NH2 is a PEG-lipid molecule featuring an oleoyl amide linked to a Gly-Lys dipeptide and a methoxy PEG11 chain on the C-terminus of the lysine. The lysine primary amine may be used in a wide variety of reactions with carboxylic acids, NHS esters, and carbonyl groups. The PEG linker provides aqueous solubility.

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