VcMMAE-d8
Based on 1 Customer Validation
VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
For research use only. We do not sell to patients.
- Purity: 97.01%
- Formula: C68H97D8N11O15
- Molecular Weight:1324.68
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 646502-53-6
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Appearance Solid
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Molecular Weight 1324.68
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Formula C68H97D8N11O15
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Color White to off-white
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SMILES
CC([C@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(N[C@H](C(NC2=CC=C(C=C2)COC(N([C@H](C(N[C@@]([2H])(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C(N([C@H]([C@@H](CC(N3[C@@H](CCC3)[C@@H]([C@H](C(N[C@@H]([C@@H](O)C4=CC=CC=C4)C)=O)C)OC)=O)OC)[C@H](CC)C)C)=O)=O)C(C)C)C)=O)=O)CCCNC(N)=O)=O)C
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Synonyms
MC-Val-Cit-PAB-MMAE-d8; mc-vc-PAB-MMAE-d8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (75.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7549 mL | 3.7745 mL | 7.5490 mL | 18.8725 mL |
| 5 mM | 0.1510 mL | 0.7549 mL | 1.5098 mL | 3.7745 mL | |
| 10 mM | 0.0755 mL | 0.3774 mL | 0.7549 mL | 1.8872 mL | |
| 15 mM | 0.0503 mL | 0.2516 mL | 0.5033 mL | 1.2582 mL | |
| 20 mM | 0.0377 mL | 0.1887 mL | 0.3774 mL | 0.9436 mL | |
| 25 mM | 0.0302 mL | 0.1510 mL | 0.3020 mL | 0.7549 mL | |
| 30 mM | 0.0252 mL | 0.1258 mL | 0.2516 mL | 0.6291 mL | |
| 40 mM | 0.0189 mL | 0.0944 mL | 0.1887 mL | 0.4718 mL | |
| 50 mM | 0.0151 mL | 0.0755 mL | 0.1510 mL | 0.3774 mL | |
| 60 mM | 0.0126 mL | 0.0629 mL | 0.1258 mL | 0.3145 mL |
VcMMAE-d8 Related Classifications
HY-15575S Related Classifications
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