2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Microtubule/Tubulin
  4. VcMMAE-d8

VcMMAE-d8  (Synonyms: MC-Val-Cit-PAB-MMAE-d8; mc-vc-PAB-MMAE-d8)

Cat. No.: HY-15575S Purity: 97.01%
COA
SDS
Handling Instructions Technical Support

VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).

For research use only. We do not sell to patients.

VcMMAE-d<sub>8</sub>

VcMMAE-d8 Chemical Structure

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of VcMMAE-d8:

VcMMAE-d8 Related Antibodies

Top Publications Citing Use of Products

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc)[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VcMMAE-d8 Related Antibodies
Molecular Weight

1324.68

Formula

C68H97D8N11O15
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

CC([C@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(N[C@H](C(NC2=CC=C(C=C2)COC(N([C@H](C(N[C@@]([2H])(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C(N([C@H]([C@@H](CC(N3[C@@H](CCC3)[C@@H]([C@H](C(N[C@@H]([C@@H](O)C4=CC=CC=C4)C)=O)C)OC)=O)OC)[C@H](CC)C)C)=O)=O)C(C)C)C)=O)=O)CCCNC(N)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (75.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7549 mL 3.7745 mL 7.5490 mL
5 mM 0.1510 mL 0.7549 mL 1.5098 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7549 mL 3.7745 mL 7.5490 mL 18.8725 mL
5 mM 0.1510 mL 0.7549 mL 1.5098 mL 3.7745 mL
10 mM 0.0755 mL 0.3774 mL 0.7549 mL 1.8872 mL
15 mM 0.0503 mL 0.2516 mL 0.5033 mL 1.2582 mL
20 mM 0.0377 mL 0.1887 mL 0.3774 mL 0.9436 mL
25 mM 0.0302 mL 0.1510 mL 0.3020 mL 0.7549 mL
30 mM 0.0252 mL 0.1258 mL 0.2516 mL 0.6291 mL
40 mM 0.0189 mL 0.0944 mL 0.1887 mL 0.4718 mL
50 mM 0.0151 mL 0.0755 mL 0.1510 mL 0.3774 mL
60 mM 0.0126 mL 0.0629 mL 0.1258 mL 0.3145 mL
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VcMMAE-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VcMMAE-d8MC-Val-Cit-PAB-MMAE-d8 mc-vc-PAB-MMAE-d8Drug-Linker Conjugates for ADCMicrotubule/TubulinDrug-Linker Conjugate for ADCInhibitorinhibitorinhibit

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