H-Trp-Tyr-OH
Based on 1 Customer Validation
H-Trp-Tyr-OH is an orally active tryptophan-tyrosine dipeptide with blood-brain barrier permeability. H-Trp-Tyr-OH exerts physiological regulatory effects by stimulating enteroendocrine cells to secrete glucagon-like peptide GLP-1. In mouse models of tauopathies, H-Trp-Tyr-OH inhibits tau phosphorylation, reduces the level of neurofibrillary tangles, increases dopamine turnover, upregulates synapsin expression, and elevates cecal short-chain fatty acid levels, thereby improving behavioral deficits and extending lifespan. H-Trp-Tyr-OH can be used in research related to impaired glucose tolerance and tauopathies.
For research use only. We do not sell to patients.
- Purity: 99.43%
- CAS No.: 19653-76-0
- Formula: C20H21N3O4
- Molecular Weight:367.40
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK | IC50 |
0.08 mM
Compound: 69
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Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
Binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells
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[PMID: 16759105] |
H-Trp-Tyr-OH (1-5 mg/mL; 60 min) potently stimulates GLP-1 secretion from GLUTag cells, with the highest activity observed at 5 mg/mL (the induced GLP-1 level is approximately 6-fold higher than that of the blank control), and exhibits no cytotoxicity against GLUTag cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:murine enteroendocrine GLUTag cells
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Concentration:1 mg/mL; 2 mg/mL; 5 mg/mL; 1.85 mg/mL
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Incubation Time:60 min
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Result:Induced a GLP-1 secretion level ~6-fold relative to blank control at 5 mg/mL.
Induced a GLP-1 level ~1-fold relative to blank control at 1 mg/mL.
Induced a GLP-1 level ~2-fold relative to blank control at 2 mg/mL.
Induced a GLP-1 level ~1.2-fold relative to blank control at 1.85 mg/mL.
Remained at baseline LDH release levels, showing no cytotoxicity.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B6;C3-Tg mice (Prnp-MAPT*P301S)PS19Vle/J (PS19 transgenic; male and female, 2.5 months old, tauopathy model); wild-type littermates (male and female, 2.5 months old)[3]
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Dosage:0.05% w/w
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Administration:p.o.; continuous dietary intake; 6.5 months (male); until 53 weeks of age (female)
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Result:Reduced total distance traveled in the open field test at 5 and 7 months of age, normalizing locomotor hyperactivity.
Increased the number of NeuN-positive cells in the entorhinal cortex and elevated cortical synaptophysin levels in male mice.
Increased dopamine turnover (DOPAC/dopamine ratio and (DOPAC + HVA)/dopamine ratio) in the frontal cortex of male mice.
Reduced hippocampal pTau levels (113.1 vs control 162.2) and cortical pTau/tTau ratio (0.02 vs control 0.04) in male mice; reduced pTau-positive region in the spinal cord.
Achieved a 67% survival ratio at 53 weeks of age in female mice, significantly higher than control's 38%.
Increased cecal acetic acid and total short-chain fatty acid levels in male mice.
Chemical Information
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CAS No. 19653-76-0
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Appearance Solid
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Molecular Weight 367.40
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Formula C20H21N3O4
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Color White to off-white
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Sequence
Trp-Tyr
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Sequence Shortening
WY
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 25 mg/mL (68.05 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Wu L, et al. Geometry and efficacy of cross-strand Trp/Trp, Trp/Tyr, and Tyr/Tyr aromatic interaction in a beta-hairpin peptide. Biochemistry. 2010;49(22):4705-4714. [Content Brief]
[3]. Ano Y, et al. Tryptophan-tyrosine dipeptide improves tau-related symptoms in tauopathy mice. Nutr Neurosci. 2023;26(8):766-777. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.7218 mL | 13.6091 mL | 27.2183 mL | 68.0457 mL |
| 5 mM | 0.5444 mL | 2.7218 mL | 5.4437 mL | 13.6091 mL | |
| 10 mM | 0.2722 mL | 1.3609 mL | 2.7218 mL | 6.8046 mL | |
| 15 mM | 0.1815 mL | 0.9073 mL | 1.8146 mL | 4.5364 mL | |
| 20 mM | 0.1361 mL | 0.6805 mL | 1.3609 mL | 3.4023 mL | |
| 25 mM | 0.1089 mL | 0.5444 mL | 1.0887 mL | 2.7218 mL | |
| 30 mM | 0.0907 mL | 0.4536 mL | 0.9073 mL | 2.2682 mL | |
| 40 mM | 0.0680 mL | 0.3402 mL | 0.6805 mL | 1.7011 mL | |
| 50 mM | 0.0544 mL | 0.2722 mL | 0.5444 mL | 1.3609 mL | |
| 60 mM | 0.0454 mL | 0.2268 mL | 0.4536 mL | 1.1341 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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