19653-76-0
Chemical Structure
H-Trp-Tyr-OH
- CAS. Nr.: 19653-76-0
- Formula:C20H21N3O4
- Molecular Weight:367.40
InChIKey: TYYLDKGBCJGJGW-WMZOPIPTSA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC([C@@H](N)CC2=CNC3=CC=CC=C23)=O
Biological Activity: H-Trp-Tyr-OH is an orally active tryptophan-tyrosine dipeptide with blood-brain barrier permeability. H-Trp-Tyr-OH exerts physiological regulatory effects by stimulating enteroendocrine cells to secrete glucagon-like peptide GLP-1. In mouse models of tauopathies, H-Trp-Tyr-OH inhibits tau phosphorylation, reduces the level of neurofibrillary tangles, increases dopamine turnover, upregulates synapsin expression, and elevates cecal short-chain fatty acid levels, thereby improving behavioral deficits and extending lifespan. H-Trp-Tyr-OH can be used in research related to impaired glucose tolerance and tauopathies[1][2][3].
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H-Trp-Tyr-OH | 99.43% | H-Trp-Tyr-OH is an orally active tryptophan-tyrosine dipeptide with blood-brain barrier permeability. H-Trp-Tyr-OH exerts physiological regulatory effects by stimulating enteroendocrine cells to secrete glucagon-like peptide GLP-1. In mouse models of tauopathies, H-Trp-Tyr-OH inhibits tau phosphorylation, reduces the level of neurofibrillary tangles, increases dopamine turnover, upregulates synapsin expression, and elevates cecal short-chain fatty acid levels, thereby improving behavioral deficits and extending lifespan. H-Trp-Tyr-OH can be used in research related to impaired glucose tolerance and tauopathies. | ||||||||||||||||||||
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- [1]. Wu L, et al. Geometry and efficacy of cross-strand Trp/Trp, Trp/Tyr, and Tyr/Tyr aromatic interaction in a beta-hairpin peptide. Biochemistry. 2010;49(22):4705-4714. [Content Brief]
- [2]. Taguchi H, et al. Trp-Tyr is a dipeptide structure that potently stimulates GLP-1 secretion in a murine enteroendocrine cell model, identified by comprehensive analysis[J]. Biochemical and biophysical research communications, 2023, 661: 28-33.
- [3]. Ano Y, et al. Tryptophan-tyrosine dipeptide improves tau-related symptoms in tauopathy mice. Nutr Neurosci. 2023;26(8):766-777. [Content Brief]
Keywords
