1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. L-Leucyl-L-Leucine methyl ester hydrochloride

L-Leucyl-L-Leucine methyl ester hydrochloride (Synonyms: LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride)

Cat. No.: HY-129905
Handling Instructions

L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress.

For research use only. We do not sell to patients.

L-Leucyl-L-Leucine methyl ester hydrochloride Chemical Structure

L-Leucyl-L-Leucine methyl ester hydrochloride Chemical Structure

CAS No. : 6491-83-4

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Description

L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress[1][2][3].

In Vitro

L-Leucyl-L-Leucine methyl ester (1 mM; 0.5-2 h) enhances LRRK2-mediated Rab10 and Rab12 phosphorylation in MEFs and A549 cells[3].
L-Leucyl-L-Leucine methyl ester (10-250 μM; 15 min) is converted to a CCI3COOH-insoluble product by CD4- lymphocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

294.82

Formula

C₁₃H₂₇ClN₂O₃

CAS No.

6491-83-4

SMILES

CC(C)C[[email protected]@H](C(OC)=O)NC([[email protected]](CC(C)C)N)=O.[H]Cl

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

L-Leucyl-L-Leucine methyl esterLLOMeLeu-Leu methyl esterH-Leu-Leu-OMeEndogenous MetabolitemonocytespolymorphonuclearleukocyteslymphocytescytotoxicendolysosomalpathwaystressInhibitorinhibitorinhibit

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Product Name:
L-Leucyl-L-Leucine methyl ester hydrochloride
Cat. No.:
HY-129905
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