L-Leucyl-L-Leucine methyl ester hydrochloride (Standard)
L-Leucyl-L-Leucine methyl ester hydrochloride (Standard) is the analytical standard of L-Leucyl-L-Leucine methyl ester hydrochloride (HY-129905). This product is intended for research and analytical applications. L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress.
For research use only. We do not sell to patients.
- CAS No.: 6491-83-4
- Formula: C13H27ClN2O3
- Molecular Weight:294.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 6491-83-4
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Molecular Weight 294.82
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Formula C13H27ClN2O3
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SMILES
CC(C)C[C@@H](C(OC)=O)NC([C@H](CC(C)C)N)=O.[H]Cl
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Synonyms
LLOMe hydrobromide (Standard); Leu-Leu methyl ester hydrobromide (Standard); H-Leu-Leu-OMe hydrobromide (Standard)
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Thiele DL, et, al. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. J Immunol. 1986 Feb 1;136(3):1038-48. [Content Brief]
[2]. Thiele DL, et, al. Mechanism of L-leucyl-L-leucine methyl ester-mediated killing of cytotoxic lymphocytes: dependence on a lysosomal thiol protease, dipeptidyl peptidase I, that is enriched in these cells. Proc Natl Acad Sci U S A. 1990 Jan;87(1):83-7. [Content Brief]
[3]. Kalogeropulou AF, et, al. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. Biochem J. 2020 Nov 27;477(22):4397-4423. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-Leucyl-L-Leucine methyl ester hydrochloride (Standard) Related Classifications
HY-129905R Related Classifications
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Keywords
- L-Leucyl-L-Leucine methyl ester hydrochloride (Standard)
- 6491-83-4
- LLOMe hydrobromide (Standard)
- Leu-Leu methyl ester hydrobromide (Standard)
- H-Leu-Leu-OMe hydrobromide (Standard)
- Reference Standards
- Endogenous Metabolite
- monocytes
- polymorphonuclear
- leukocytes
- lymphocytes
- cytotoxic
- endolysosomal
- pathway
- stress
- Inhibitor
- inhibitor
- inhibit