6491-83-4
6491-83-4
Chemical Structure
L-Leucyl-L-Leucine methyl ester hydrochloride
Synonym(s): LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride
- CAS. Nr.: 6491-83-4
- Formula:C13H27ClN2O3
- Molecular Weight:294.82
IUPAC Name: methyl L-leucyl-L-leucinate hydrochloride
InChIKey: RVXQFTNCULOWRV-ACMTZBLWSA-N
SMILES: CC(C)C[C@@H](C(OC)=O)NC([C@H](CC(C)C)N)=O.[H]Cl
Biological Activity: L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) hydrochloride is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester hydrochloride can be used for research related to lysosomal function and apoptosis[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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L-Leucyl-L-Leucine methyl ester hydrochloride | 99.09% | L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) hydrochloride is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester hydrochloride can be used for research related to lysosomal function and apoptosis. | ||||||||||||||||||||
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L-Leucyl-L-Leucine methyl ester hydrochloride (Standard) | ≥98% | L-Leucyl-L-Leucine methyl ester hydrochloride (Standard) (LLOMe hydrochloride (Standard); Leu-Leu methyl ester hydrochloride (Standard); H-Leu-Leu-OMe hydrochloride (Standard)) is the analytical standard of L-Leucyl-L-Leucine methyl ester hydrochloride (HY-129905). This product is intended for research and analytical applications. L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) hydrochloride is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester hydrochloride can be used for research related to lysosomal function and apoptosis. | ||||||||||||||||||||
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L-Leucyl-L-Leucine methyl ester hydrochloride (solution) | L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) hydrochloride (solution) is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester hydrochloride (solution) can be used for research related to lysosomal function and apoptosis. | |||||||||||||||||||||
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L-Leucyl-L-Leucine methyl ester hydrobromide | 99.82% | L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) hydrobromide is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester hydrobromide can be used for research related to lysosomal function and apoptosis. | ||||||||||||||||||||
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L-Leucyl-L-Leucine methyl ester | L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester can be used for research related to lysosomal function and apoptosis. | |||||||||||||||||||||
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H-Leu-Asn-OH | 95.77% | H-Leu-Asn-OH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development. | ||||||||||||||||||||
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H-Leu-Asp-OH | H-Leu-Asp-OH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development. | |||||||||||||||||||||
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H-Leu-Leu-Ala-OH | H-Leu-Leu-Ala-OH is a tripeptide composed of two L-leucine units joined to L-alanine by a peptide linkage. H-Leu-Leu-Ala-OH shows antioxidant activities. | |||||||||||||||||||||
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Valylleucine | Valylleucine (Val-Leu; H-Val-Leu-OH) is a branched-chain dipeptide that can enter cells independently via bacterial dipeptide transport systems, and is hydrolyzed by dipeptidases to release Val and Leu. Valylleucine, as a model peptide, has its α-amino pK determined to be 7.90 by combining FDNB reaction kinetics with potentiometric titration. | |||||||||||||||||||||
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Leu-Leu-OH | 99.10% | Leu-Leu-OH (L-Leucyl-L-leucine), a Leu derivative, is a neutral dipeptide that can be used to study the functionality of dileucine motifs. | ||||||||||||||||||||
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L-Leucyl-L-isoleucine | 99.89% | L-Leucyl-L-isoleucine (Leucylisoleucine) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Ile-Leu-OH | Ile-Leu-OH (L-Isoleucyl-L-leucine) is a hydrophobic dipeptide fragment and is a component of the neurotensin C-terminal heptapeptide Pro-Arg-Arg-Pro-Tyr-Ile-LeuOH. | |||||||||||||||||||||
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Thr-Leu | 99.86% | Thr-Leu is a dipeptide composed of threonine and leucine. Thr-Leu can be hydrolyzed in the peritoneal cavity to generate constituent amino acids, thereby increasing the osmotic pressure of the dialysate. Thr-Leu can be used for the kinetic study of amino acid-based peritoneal dialysis fluids. | ||||||||||||||||||||
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References
- [1]. Uchimoto T, Nohara H, Kamehara R, Iwamura M, Watanabe N, Kobayashi Y. Mechanism of apoptosis induced by a lysosomotropic agent, L-Leucyl-L-Leucine methyl ester. Apoptosis. 1999 Oct;4(5):357-62.
- [2]. Urska Repnik, et al. L-leucyl-L-leucine methyl ester does not release cysteine cathepsins to the cytosol but inactivates them in transiently permeabilized lysosomes. J Cell Sci 15 September 2017; 130 (18): 3124-3140.
- [3]. Thiele DL, et al. Regulation of cellular function by products of lysosomal enzyme activity: elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 1985 Apr;82(8):2468-72.
