1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. Dap-NE hydrochloride

Dap-NE hydrochloride is a dipeptide hydrochloride and a cleavable ADC Linker.Dap-NE hydrochloride can be used to connect Antibody and toxin molecules (Cytotoxin) to synthesize Antibody-Drug Conjugates (ADCs).

For research use only. We do not sell to patients.

Dap-NE hydrochloride Chemical Structure

Dap-NE hydrochloride Chemical Structure

CAS No. : 2019182-02-4

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Based on 1 publication(s) in Google Scholar

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Description

Dap-NE hydrochloride is a dipeptide hydrochloride and a cleavable ADC Linker.Dap-NE hydrochloride can be used to connect Antibody and toxin molecules (Cytotoxin) to synthesize Antibody-Drug Conjugates (ADCs)[1].

Molecular Weight

356.89

Formula

C18H29ClN2O3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C)[C@@H](O)C1=CC=CC=C1)[C@H](C)[C@@H](OC)[C@H]2NCCC2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (280.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8020 mL 14.0099 mL 28.0198 mL
5 mM 0.5604 mL 2.8020 mL 5.6040 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.98%

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8020 mL 14.0099 mL 28.0198 mL 70.0496 mL
5 mM 0.5604 mL 2.8020 mL 5.6040 mL 14.0099 mL
10 mM 0.2802 mL 1.4010 mL 2.8020 mL 7.0050 mL
15 mM 0.1868 mL 0.9340 mL 1.8680 mL 4.6700 mL
20 mM 0.1401 mL 0.7005 mL 1.4010 mL 3.5025 mL
25 mM 0.1121 mL 0.5604 mL 1.1208 mL 2.8020 mL
30 mM 0.0934 mL 0.4670 mL 0.9340 mL 2.3350 mL
40 mM 0.0700 mL 0.3502 mL 0.7005 mL 1.7512 mL
50 mM 0.0560 mL 0.2802 mL 0.5604 mL 1.4010 mL
60 mM 0.0467 mL 0.2335 mL 0.4670 mL 1.1675 mL
80 mM 0.0350 mL 0.1751 mL 0.3502 mL 0.8756 mL
100 mM 0.0280 mL 0.1401 mL 0.2802 mL 0.7005 mL
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Dap-NE hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Dap-NE hydrochloride
Cat. No.:
HY-78932A
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