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  4. H-Ile-Ala-OH

H-Ile-Ala-OH  (Synonyms: Ile-Ala; L-Isoleucyl-L-alanine)

Cat. No.: HY-141460 Purity: 98.0%
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H-Ile-Ala-OH (Ile-Ala; L-Isoleucyl-L-alanine) is a linear aliphatic dipeptide and self-reactive cyclization reagent that self-assembles into amorphous films or spherical structures from specific solvents. H-Ile-Ala-OH also serves as a precursor for the synthesis of the cyclic peptide cyclo (L-isoleucyl-L-alanine) (HY-N9251). H-Ile-Ala-OH undergoes solid-state cyclization when heated above 206 °C, and its initiation temperature is closely related to the size of side-chain substituents.

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H-Ile-Ala-OH

H-Ile-Ala-OH Chemical Structure

CAS No. : 24787-73-3

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H-Ile-Ala-OH Related Antibodies

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Description

H-Ile-Ala-OH (Ile-Ala; L-Isoleucyl-L-alanine) is a linear aliphatic dipeptide and self-reactive cyclization reagent that self-assembles into amorphous films or spherical structures from specific solvents. H-Ile-Ala-OH also serves as a precursor for the synthesis of the cyclic peptide cyclo (L-isoleucyl-L-alanine) (HY-N9251). H-Ile-Ala-OH undergoes solid-state cyclization when heated above 206 °C, and its initiation temperature is closely related to the size of side-chain substituents[1].

In Vitro

L-isoleucyl-L-alanine (4 mg; 206 °C) undergoes autocatalytic cyclization to form cyclo (L-Ile-L-Ala), with an average activation energy of 223.16 kJ/mol, and conforms to the optimally fitted autocatalytic kinetic model[1].
When deposited on the surface of HOPG, L-isoleucyl-L-alanine (1-20 mg/mL) self-assembles into amorphous thin films in 2 mg/mL HFIP solution and 1 mg/mL methanol solution, while it forms spherical aggregates in 20 mg/mL HFIP solution[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

H-Ile-Ala-OH Related Antibodies
Molecular Weight

202.25

Formula

C9H18N2O3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CC[C@H](C)[C@H](N)C(N[C@@H](C)C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (61.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9444 mL 24.7219 mL 49.4438 mL
5 mM 0.9889 mL 4.9444 mL 9.8888 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.9444 mL 24.7219 mL 49.4438 mL 123.6094 mL
5 mM 0.9889 mL 4.9444 mL 9.8888 mL 24.7219 mL
10 mM 0.4944 mL 2.4722 mL 4.9444 mL 12.3609 mL
15 mM 0.3296 mL 1.6481 mL 3.2963 mL 8.2406 mL
20 mM 0.2472 mL 1.2361 mL 2.4722 mL 6.1805 mL
25 mM 0.1978 mL 0.9889 mL 1.9778 mL 4.9444 mL
30 mM 0.1648 mL 0.8241 mL 1.6481 mL 4.1203 mL
40 mM 0.1236 mL 0.6180 mL 1.2361 mL 3.0902 mL
50 mM 0.0989 mL 0.4944 mL 0.9889 mL 2.4722 mL
60 mM 0.0824 mL 0.4120 mL 0.8241 mL 2.0602 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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H-Ile-Ala-OH Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

H-Ile-Ala-OH24787-73-3Ile-Ala L-Isoleucyl-L-alanineBiochemical Assay Reagentssolid-state cyclizationspherical objectscyclo(L-isoleucyl-L-alanine)hexafluoro-2-propanolL-isoleucyl-L-alaninelinear aliphatic dipeptideHOPGamorphous filmsmethanolautocatalytic nth-order mechanismInhibitorinhibitorinhibit

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