2. JE-2147

JE-2147 (AG1776) is a potent dipeptide protease inhibitor with a Ki of 0.33 nM for HIV-1 protease. JE-2147 has effective activities against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro.

For research use only. We do not sell to patients.

JE-2147 Chemical Structure

JE-2147 Chemical Structure

CAS No. : 186538-00-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

JE-2147 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

JE-2147 (AG1776) is a potent dipeptide protease inhibitor with a Ki of 0.33 nM for HIV-1 protease. JE-2147 has effective activities against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro[1][2].

IC50 & Target

IC50: 44 nM [HIV-1LAI (SI)], 24 nM [HIV-1Ba-L (SI)], 35 nM [HIV-1LAI (NSI)], 47 nM [HIV-2EHO (SI)][1]
Ki:0.33 nM (HIV-1 protease)[2]
In Vitro

JE-2147 (0.01-0.05 μM; 7 days; PBMC and MT-2 cells) exhibits highly potent antiviral activity against HIV-1 with IC50s of 44 nM, 24 nM, 35 nM and 47 nM for HIV-1LAI (SI), HIV-1Ba-L (SI), HIV-1LAI (NSI) and HIV-2EHO (SI), respectively[1].
JE-2147 is effective against the replication of HIV-1 IIIB in various cells (T cell, B cell, macrophage, and PBMC) with IC50 values ranging from 31 to 160 nM and also had antiviral activity against simian immunodefidiency virus and HIV-2[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JE-2147 Related Antibodies
In Vivo

JE-2147 exhibits good oral bioavailability and plasma pharmacokinetic profiles in dogs and rats[2].
Pharmacokinetic Parameters of JE-2147 in beagle dogs and male Sprague-Dawley rats[2].

Sprague-Dawley rats Beagle dogs
i.v., 10 mg/kg i.d., 10 mg/kg i.v., 25 mg/kg p.o.(fed), 25 mg/kg p.o.(fasted), 25 mg/kg
t1/2β (min) 93 / 94 / /
Cmax (μM) / 0.70 ± 0.20 / 4.02 ± 0.72 5.30 ± 1.13
Tmax (min) / 60 / 90 60
F (%) / 41.6 ± 10.7 / 32.6 ± 0.06 37.1 ± 0.08
CL (L/h/kg) / / 0.88 ± 0.09 / /
Vd, ss (L/kg) / / 1.58 / /
AUC0-24 (μM·min) / / / 1009 1149

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Beagle dogs and male Sprague-Dawley rats[2]
Dosage: 25 mg/kg for dogs; 10 mg/kg for rats
Administration: i.v. and i.d. for rats; i.v. and p.o. for dogs.
Result: Exhibited favorable pharmacokinetic properties.
Molecular Weight

575.72

Formula

C32H37N3O5S
CAS No.
SMILES

CC(C=CC=C1)=C1CNC([C@H]2N(CSC2(C)C)C([C@@H](O)[C@@H](NC(C3=C(C(O)=CC=C3)C)=O)CC4=CC=CC=C4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JE-2147186538-00-1AG1776 KNI-764JE2147JE 2147AG 1776AG-1776KNI764KNI 764KNI-764Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
JE-2147
Cat. No.:
HY-100212
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.