186538-00-1
Chemical Structure
JE-2147
Synonym(s): AG1776;KNI-764
- CAS No.: 186538-00-1
- Formula:C32H37N3O5S
- Molecular Weight:575.72
IUPAC Name: (R)-3-((2S,3S)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-phenylbutanoyl)-5,5-dimethyl-N-(2-methylbenzyl)thiazolidine-4-carboxamide
InChIKey: CUFQBQOBLVLKRF-RZDMPUFOSA-N
SMILES: CC(C=CC=C1)=C1CNC([C@H]2N(CSC2(C)C)C([C@@H](O)[C@@H](NC(C3=C(C(O)=CC=C3)C)=O)CC4=CC=CC=C4)=O)=O
Biological Activity: JE-2147 (AG1776) is a potent dipeptide protease inhibitor with a Ki of 0.33 nM for HIV-1 protease. JE-2147 has effective activities against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
JE-2147 | JE-2147 (AG1776) is a potent dipeptide protease inhibitor with a Ki of 0.33 nM for HIV-1 protease. JE-2147 has effective activities against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Yoshimura K, et al. JE-2147: a dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8675-80. [Content Brief]
- [2]. Mimoto T, et al. Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine. J Med Chem. 1999 May 20;42(10):1789-802. [Content Brief]
Keywords
