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  4. L-BPA-BPA

L-BPA-BPA is an aromatic dipeptide and an analog of L-BPA (HY-W087830). L-BPA-BPA undergoes rapid hydrolytic cleavage in vivo to release the boron neutron capture agent L-BPA. L-BPA-BPA enables boron delivery to tumors; when used in combination with neutron irradiation, it also induces immunological effects including vaccine responses and abscopal tumor suppression. L-BPA-BPA can be used in the research of colon cancer and hypopharyngeal cancer.

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L-BPA-BPA

L-BPA-BPA Chemical Structure

CAS No. : 2941355-30-0

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L-BPA-BPA Related Antibodies

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Description

L-BPA-BPA is an aromatic dipeptide and an analog of L-BPA (HY-W087830). L-BPA-BPA undergoes rapid hydrolytic cleavage in vivo to release the boron neutron capture agent L-BPA. L-BPA-BPA enables boron delivery to tumors; when used in combination with neutron irradiation, it also induces immunological effects including vaccine responses and abscopal tumor suppression. L-BPA-BPA can be used in the research of colon cancer and hypopharyngeal cancer[1].

Parmacokinetics
Species Dose Route T1/2 Cmax
Mice[1] 200 mg/kg i.v. 218.3 min 362.8 μg/mL
Mice[1] 800 mg/kg i.v. 196.89 min 1503.8 μg/mL
In Vivo

L-BPA-BPA (800-900 mg/kg; i.v.; single bolus) administered followed by neutron irradiation delivers sustained high intratumoral boron concentrations, induces durable complete regression of CT26 colon carcinoma tumors in BALB/c mice, and elicits antitumor vaccine and abscopal immune effects[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (female, for biodistribution; 7-week-old, for BNCT efficacy)[1]
Dosage: 800 mg/kg; 900 mg/kg
Administration: i.v.; single bolus
Result: Delivered higher tumor boron concentrations compared to 200 mg/kg L-BPA.
Suppressed tumor growth at day 25 with 12-minute neutron irradiation.
Maintained robust tumor suppression with 6-minute neutron irradiation, while 200 mg/kg L-BPA only delayed growth.
Produced durable complete tumor regression in all treated mice through day 43 with 6-minute neutron irradiation, with no viable tumor cells detected.
Induced a vaccine effect: all mice rejected CT26 cell rechallenge in the contralateral hind leg, while naïve mice developed progressive tumors.
Induced marked regression of the irradiated index tumor and a 34% growth delay in the unirradiated contralateral tumor in a bilateral tumor model.
Molecular Weight

400.00

Formula

C18H22B2N2O7
CAS No.
SMILES

OB(O)C1=CC=C(C[C@H](N)C(N[C@@H](CC2=CC=C(B(O)O)C=C2)C(O)=O)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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L-BPA-BPA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-BPA-BPA2941355-30-0Drug DerivativeDrug derivativeFaDu cellshuman FaDu hypopharyngeal carcinoma xenograftsboron neutron capture therapyBALB/c nude miceAsPC-1 cellshypopharyngeal carcinomacolon carcinomaBALB/c micePEPT1/2 transportersCT26 colon carcinoma tumorsInhibitorinhibitorinhibit

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