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Cat. No.: HY-183597

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L-BPA-BPA

L-BPA-BPA is an aromatic dipeptide and an analog of L-BPA (HY-W087830). L-BPA-BPA undergoes rapid hydrolytic cleavage in vivo to release the boron neutron capture agent L-BPA. L-BPA-BPA enables boron delivery to tumors; when used in combination with neutron irradiation, it also induces immunological effects including vaccine responses and abscopal tumor suppression. L-BPA-BPA can be used in the research of colon cancer and hypopharyngeal cancer.

For research use only. We do not sell to patients.

CAS No.: 2941355-30-0
Formula: C₁₈H₂₂B₂N₂O₇
Molecular Weight:400.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

L-BPA-BPA Chemical Structure

CAS No.: 2941355-30-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

Parmacokinetics

Species	Dose	Route	T_1/2	C_max
Mice^[1]	200 mg/kg	i.v.	218.3 min	362.8 μg/mL
Mice^[1]	800 mg/kg	i.v.	196.89 min	1503.8 μg/mL

In Vivo

L-BPA-BPA (800-900 mg/kg; i.v.; single bolus) administered followed by neutron irradiation delivers sustained high intratumoral boron concentrations, induces durable complete regression of CT26 colon carcinoma tumors in BALB/c mice, and elicits antitumor vaccine and abscopal immune effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice (female, for biodistribution; 7-week-old, for BNCT efficacy)^[1]
Dosage:

800 mg/kg; 900 mg/kg
Administration:

i.v.; single bolus
Result:

Delivered higher tumor boron concentrations compared to 200 mg/kg L-BPA.
Suppressed tumor growth at day 25 with 12-minute neutron irradiation.
Maintained robust tumor suppression with 6-minute neutron irradiation, while 200 mg/kg L-BPA only delayed growth.
Produced durable complete tumor regression in all treated mice through day 43 with 6-minute neutron irradiation, with no viable tumor cells detected.
Induced a vaccine effect: all mice rejected CT26 cell rechallenge in the contralateral hind leg, while naïve mice developed progressive tumors.
Induced marked regression of the irradiated index tumor and a 34% growth delay in the unirradiated contralateral tumor in a bilateral tumor model.

Chemical Information

CAS No. 2941355-30-0
Molecular Weight 400.00
Formula C₁₈H₂₂B₂N₂O₇
SMILES

OB(O)C1=CC=C(C[C@H](N)C(N[C@@H](CC2=CC=C(B(O)O)C=C2)C(O)=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Torgov M, et al. l‑Boronophenylalanine (l-BPA) Dipeptide Prodrugs Enhance Boron Delivery to Tumors, Facilitate Tumor Eradication and Induce Tumor Vaccine Effect in Mice Following Neutron Irradiation. ACS Pharmacol Transl Sci. 2026;9(4):888-901. Published 2026 Mar 18. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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