L-BPA-BPA hydrochloride
Based on 1 Customer Validation
L-BPA-BPA hydrochloride is an aromatic dipeptide and an analog of L-BPA (HY-W087830). L-BPA-BPA hydrochloride undergoes rapid hydrolytic cleavage in vivo to release the boron neutron capture agent L-BPA. L-BPA-BPA hydrochloride enables boron delivery to tumors; when used in combination with neutron irradiation, it also induces immunological effects including vaccine responses and abscopal tumor suppression. L-BPA-BPA hydrochloride can be used in the research of colon cancer and hypopharyngeal cancer.
For research use only. We do not sell to patients.
- Purity: 97.42%
- Formula: C18H23B2ClN2O7
- Molecular Weight:436.46
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c mice (female, for biodistribution; 7-week-old, for BNCT efficacy)[1]
-
Dosage:800 mg/kg; 900 mg/kg
-
Administration:i.v.; single bolus
-
Result:Delivered higher tumor boron concentrations compared to 200 mg/kg L-BPA.
Suppressed tumor growth at day 25 with 12-minute neutron irradiation.
Maintained robust tumor suppression with 6-minute neutron irradiation, while 200 mg/kg L-BPA only delayed growth.
Produced durable complete tumor regression in all treated mice through day 43 with 6-minute neutron irradiation, with no viable tumor cells detected.
Induced a vaccine effect: all mice rejected CT26 cell rechallenge in the contralateral hind leg, while naïve mice developed progressive tumors.
Induced marked regression of the irradiated index tumor and a 34% growth delay in the unirradiated contralateral tumor in a bilateral tumor model.
Chemical Information
-
Appearance Solid
-
Molecular Weight 436.46
-
Formula C18H23B2ClN2O7
-
Color White to off-white
-
SMILES
OB(O)C1=CC=C(C[C@H](N)C(N[C@@H](CC2=CC=C(B(O)O)C=C2)C(O)=O)=O)C=C1.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
-
Data Sheet (271 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-BPA-BPA hydrochloride Related Classifications
HY-183597A Related Classifications
Powered by Bioz