2. Neuronal Signaling
  3. Amyloid-β
  4. Carnosine conjugated hyalyronate

Carnosine conjugated hyalyronate is a hyaluronic acid derivative functionalized with the dipeptide carnosine (Carnosine, Car) and has the ability to resist Aβ amyloid aggregation. Carnosine conjugated hyalyronate dissolves amyloid fibrils and reduces Aβ-induced toxicity in vitro. The effectiveness of Carnosine conjugated hyalyronate against amyloid aggregation is directly proportional to the Carnosine loading.

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Carnosine conjugated hyalyronate

Carnosine conjugated hyalyronate Estructura química

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Based on 1 publication(s) in Google Scholar

Carnosine conjugated hyalyronate Related Antibodies

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Descripciòn

Carnosine conjugated hyalyronate is a hyaluronic acid derivative functionalized with the dipeptide carnosine (Carnosine, Car) and has the ability to resist Aβ amyloid aggregation. Carnosine conjugated hyalyronate dissolves amyloid fibrils and reduces Aβ-induced toxicity in vitro. The effectiveness of Carnosine conjugated hyalyronate against amyloid aggregation is directly proportional to the Carnosine loading[1].

Peso molecular

600000(Average)

Appearance

Solid

Color

White to off-white

SMILES

OC[C@H]1O[C@@H](OC)[C@H](NC(C)=O)[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O[C@H]3[C@H](NC(C)=O)[C@@H](O[C@H]4[C@H](O)[C@H](O)[C@H](OC)[C@@H](C(NCCC(N[C@H](C(O[Na])=O)CC5=CNC=N5)=O)=O)O4)[C@H](O)[C@@H](CO)O3)[C@@H](C([O-])=O)O2)[C@@H]1O.[Na+]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

H2O : 25 mg/mL (ultrasonic and warming and heat to 60°C)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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Pureza y Documentación

Purity: 90.0%

SDS (251 KB)

COA (250 KB) HNMR (269 KB)

Instrucciones de manejo (2659 KB)
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Carnosine conjugated hyalyronate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carnosine conjugated hyalyronateAmyloid-ββ-amyloid peptideAβAbetaDipeptide carnosineamyloid aggregatesInhibitorinhibitorinhibit

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Nombre del producto:
Carnosine conjugated hyalyronate
Cat. No.:
HY-148495
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