Leucyl-phenylalanine
Based on 1 Customer Validation
Leucyl-phenylalanine is a linear dipeptide composed of L-leucine and L-phenylalanine, and also serves as a cyclization substrate. Leucyl-phenylalanine is an incomplete degradation product generated during protein breakdown or catabolism. Leucyl-phenylalanine undergoes heat-induced solid-state cyclization via an autocatalytic mechanism to form its cyclic diketopiperazine analog.
For research use only. We do not sell to patients.
- Purity : 99.21%
- CAS No.: 3063-05-6
- Formula: C15H22N2O3
- Molecular Weight:278.35
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
Leucyl-phenylalanine (Leu-Phe) undergoes solid-state cyclization, which is an autocatalytic reaction[1].
Leucyl-phenylalanine exists in neutral form in amorphous films and in zwitterionic form in crystalline films; heating to 100-120 °C triggers a cyclization reaction via conversion to the neutral form, and the cyclization reaction completes upon heating to 140 °C[1].
Leucyl‑phenylalanine smoothes its initial flocculent structure upon heating to 110 °C, and further heating to 150 °C triggers the generation of fibrous structures[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3063-05-6
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Appearance Solid
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Molecular Weight 278.35
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Formula C15H22N2O3
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Color White to off-white
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SMILES
O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H](CC(C)C)N)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
H2O : 4 mg/mL (14.37 mM; Need ultrasonic)
Ethanol : 1.11 mg/mL (3.99 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 2 mg/mL (7.19 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
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Data Sheet (282 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / H2O | 1 mM | 3.5926 mL | 17.9630 mL | 35.9260 mL | 89.8150 mL |
| H2O | 5 mM | 0.7185 mL | 3.5926 mL | 7.1852 mL | 17.9630 mL |
| 10 mM | 0.3593 mL | 1.7963 mL | 3.5926 mL | 8.9815 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Leucyl-phenylalanine Related Classifications
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