PROTAC ALK degrader-4
PROTAC ALK degrader-4 (Compound B8) is an ALK PROTAC degrader with a DC50 of 445.25 nM. PROTAC ALK degrader-4 exhibits excellent anti-proliferative activity against NCI-H2228 and NCI-H3122. PROTAC ALK degrader-4 leads to a significant downregulation of 390 proteins, including IGF-1R and its downstream proteins such as ERK1/2 and STAT3. PROTAC ALK degrader-4 can be used for research on lung adenocarcinoma.
(Pink: Anaplastic lymphoma kinase (ALK) ligand (HY-15656); Blue: Cereblon ligand (HY-179733); Black: linker).
For research use only. We do not sell to patients.
- Formula: C46H63ClN8O7S
- Molecular Weight:907.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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Molecular Weight 907.56
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Formula C46H63ClN8O7S
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SMILES
CC1=CC(NC2=NC(NC3=CC=CC=C3S(=O)(C(C)C)=O)=C(C=N2)Cl)=C(C=C1C4CCN(CC4)CCCCCCCC(NC5(CCC5)C(NC6C(NC(CC6)=O)=O)=O)=O)OC(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC ALK degrader-4 Related Classifications
HY-179732 Related Classifications
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- PROTAC ALK degrader-4
- PROTAC ALK degrader4
- PROTAC ALK degrader 4
- PROTACs
- Anaplastic lymphoma kinase (ALK)
- IGF-1R
- ERK
- STAT
- PROTAC
- CRBN ligands
- unnatural dipeptide
- ALK degradation
- cereblon
- targeted protein degradation
- molecular glues
- ubiquitin-proteasome system
- kinase inhibitors
- structure-activity relationship
- Inhibitor
- inhibitor
- inhibit