2. PROTAC Protein Tyrosine Kinase/RTK Stem Cell/Wnt MAPK/ERK Pathway JAK/STAT Signaling
  3. PROTACs Anaplastic lymphoma kinase (ALK) IGF-1R ERK STAT
  4. PROTAC ALK degrader-4

PROTAC ALK degrader-4 (Compound B8) is an ALK PROTAC degrader with a DC50 of 445.25 nM. PROTAC ALK degrader-4 exhibits excellent anti-proliferative activity against NCI-H2228 and NCI-H3122. PROTAC ALK degrader-4 leads to a significant downregulation of 390 proteins, including IGF-1R and its downstream proteins such as ERK1/2 and STAT3. PROTAC ALK degrader-4 can be used for research on lung adenocarcinoma. (Pink: ALK ligand (HY-15656); Blue: CRBN ligand (HY-179733); Black: linker).

For research use only. We do not sell to patients.

PROTAC ALK degrader-4

PROTAC ALK degrader-4 Chemical Structure

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PROTAC ALK degrader-4 Related Antibodies

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Description

PROTAC ALK degrader-4 (Compound B8) is an ALK PROTAC degrader with a DC50 of 445.25 nM. PROTAC ALK degrader-4 exhibits excellent anti-proliferative activity against NCI-H2228 and NCI-H3122. PROTAC ALK degrader-4 leads to a significant downregulation of 390 proteins, including IGF-1R and its downstream proteins such as ERK1/2 and STAT3. PROTAC ALK degrader-4 can be used for research on lung adenocarcinoma. (Pink: ALK ligand (HY-15656); Blue: CRBN ligand (HY-179733); Black: linker)[1].

Molecular Weight

907.56

Formula

C46H63ClN8O7S
SMILES

CC1=CC(NC2=NC(NC3=CC=CC=C3S(=O)(C(C)C)=O)=C(C=N2)Cl)=C(C=C1C4CCN(CC4)CCCCCCCC(NC5(CCC5)C(NC6C(NC(CC6)=O)=O)=O)=O)OC(C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC ALK degrader-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC ALK degrader-4PROTAC ALK degrader4PROTAC ALK degrader 4PROTACsAnaplastic lymphoma kinase (ALK)IGF-1RERKSTATAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Insulin-like growth factor-1 receptorExtracellular signal regulated kinasesPROTACCRBN ligandsunnatural dipeptideALK degradationcereblontargeted protein degradationmolecular gluesubiquitin-proteasome systemkinase inhibitorsstructure-activity relationshipInhibitorinhibitorinhibit

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PROTAC ALK degrader-4
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HY-179732
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