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Cat. No.: HY-179732

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PROTAC ALK degrader-4

PROTAC ALK degrader-4 (Compound B8) is an ALK PROTAC degrader with a DC₅₀ of 445.25 nM. PROTAC ALK degrader-4 exhibits excellent anti-proliferative activity against NCI-H2228 and NCI-H3122. PROTAC ALK degrader-4 leads to a significant downregulation of 390 proteins, including IGF-1R and its downstream proteins such as ERK1/2 and STAT3. PROTAC ALK degrader-4 can be used for research on lung adenocarcinoma.
(Pink: Anaplastic lymphoma kinase (ALK) ligand (HY-15656); Blue: Cereblon ligand (HY-179733); Black: linker).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₄₆H₆₃ClN₈O₇S
Masse moléculaire:907.56

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

PROTAC ALK degrader-4 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

PROTAC ALK degrader-4 (Compound B8) is an ALK PROTAC degrader with a DC₅₀ of 445.25 nM. PROTAC ALK degrader-4 exhibits excellent anti-proliferative activity against NCI-H2228 and NCI-H3122. PROTAC ALK degrader-4 leads to a significant downregulation of 390 proteins, including IGF-1R and its downstream proteins such as ERK1/2 and STAT3. PROTAC ALK degrader-4 can be used for research on lung adenocarcinoma^[1]. (Pink: Anaplastic lymphoma kinase (ALK) ligand (HY-15656); Blue: Cereblon ligand (HY-179733); Black: linker).

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform ERK :

Voir tous les produits spécifiques à Isoform STAT :

Chemical Information

Masse moléculaire 907.56
Formule C₄₆H₆₃ClN₈O₇S
SMILES

CC1=CC(NC2=NC(NC3=CC=CC=C3S(=O)(C(C)C)=O)=C(C=N2)Cl)=C(C=C1C4CCN(CC4)CCCCCCCC(NC5(CCC5)C(NC6C(NC(CC6)=O)=O)=O)=O)OC(C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Huang K, et al. Design, synthesis, and biological evaluation of novel PROTACs based on unnatural dipeptide CRBN ligands. Eur J Med Chem. 2026 Feb 5;303:118387. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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Cat. No.:
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MCE Japan Authorized Agent:

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PROTAC ALK degrader-4

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform ERK

Voir tous les produits spécifiques à Isoform STAT

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PROTAC ALK degrader-4 Related Classifications

HY-179732 Related Classifications