1. Cytoskeleton
  2. Gap Junction Protein
  3. Danegaptide

Danegaptide (Synonyms: GAP-134; ZP 1609)

Cat. No.: HY-10913
Handling Instructions

Danegaptide (GAP-134), a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.

For research use only. We do not sell to patients.

Danegaptide Chemical Structure

Danegaptide Chemical Structure

CAS No. : 943134-39-2

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Description

Danegaptide (GAP-134), a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.

IC50 & Target

Gap junction.

In Vitro

Gap junction uncoupling can alter conduction pathways and promote cardiac re-entry mechanisms that potentiate many supraventricular arrhythmias, such as atrial fibrillation (AF) and atrial flutter (AFL). Gap junction modifier Danegaptide (GAP-134), showed consistent efficacy on measures of conduction and AF/AFL inducibility in the canine sterile pericarditis model. Danegaptide (GAP-134) is a pharmalogical agent with a favorable clinical safety profile and potential antiarrhythmic efficacy, as already confirmed in phase I clinical trials.

Clinical Trial
Molecular Weight

291.30

Formula

C₁₄H₁₇N₃O₄

CAS No.

943134-39-2

SMILES

O=C(N[[email protected]]1CN(C(CN)=O)[[email protected]](C(O)=O)C1)C2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DanegaptideGAP-134ZP 1609GAP134GAP 134ZP1609ZP-1609Gap Junction ProteinInhibitorinhibitorinhibit

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