943134-39-2
943134-39-2
Chemical Structure
Danegaptide
Synonym(s): GAP-134; ZP 1609
- CAS No.: 943134-39-2
- Formula:C14H17N3O4
- Molecular Weight:291.30
IUPAC Name: (2S,4R)-4-benzamido-1-glycylpyrrolidine-2-carboxylic acid
InChIKey: BIZKIHUJGMSVFD-MNOVXSKESA-N
SMILES: O=C(N[C@H]1CN(C(CN)=O)[C@H](C(O)=O)C1)C2=CC=CC=C2
Biological Activity: Danegaptide (GAP-134) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect[1][2].
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Danegaptide | Danegaptide (GAP-134) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect. | |||||||||||||||||||||
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Danegaptide-d5 | Danegaptide-d5 (GAP-134-d5) is deuterium labeled Danegaptide. Danegaptide (GAP-134) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect. | |||||||||||||||||||||
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References
- [1]. John A Butera, et al. Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation. J Med Chem. 2009 Feb 26;52(4): [Content Brief]
- [2]. Elke De Vuyst, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163(3):469-83. [Content Brief]
Keywords
