Cyclo(L-Leu-L-Pro)
Based on 1 Customer Validation
Cyclo(L-Leu-L-Pro) is a cyclic dipeptide with broad-spectrum antibacterial, antiviral and antifungal activities. Its biological activity is highly dependent on the stereoconfiguration and is widely present in microbial metabolites. Cyclo(L-Leu-L-Pro) efficiently and specifically inhibits the production of aflatoxin by Aspergillus flavus. The cis configuration of Cyclo(L-Leu-L-Pro) (cis-cyclo(L-Leu-L-Pro)) has broad-spectrum antibacterial activity against multi-drug resistant bacteria and significantly inhibits the influenza A virus H3N2.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.95%
- CAS 番号: 2873-36-1
- 分子式: C11H18N2O2
- 分子量:210.27
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保管条件:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
体外実験
Cyclo(L-Leu-L-Pro) (0.1-12 mg/mL, 2-3 days) inhibits the accumulation of norsolinoic acid (NA) in the mutant strain NFRI-95 of Aspergillus parasiticus, and inhibits spore formation[1].
Cyclo(L-Leu-L-Pro) (4 d) exhibits inhibitory effects on the production of aflatoxins by Aspergillus parasiticus SYS-4, with an IC50 value of 0.2 mg/mL[1].
Cyclo(L-Leu-L-Pro) (1-100 μg/mL, 1-7 days) has a significant inhibitory effect on the germination of Colletotrichum orbiculare spores, effectively interfering with the formation of the pathogen's infection structure and reducing the severity of cucumber anthracnose disease[2].
Cis-cyclo(L-Leu-L-Pro) exhibits significant inhibitory effects on the influenza A virus H3N2 and on multidrug-resistant bacteria (such as S. aureus and S. Typhimurium)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2873-36-1
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性状 Solid
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分子量 210.27
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分子式 C11H18N2O2
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Color White to off-white
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別名
Cyclo(L-prolyl-L-leucyl)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
溶剤 & 溶解度
体外:
DMSO : ≥ 100 mg/mL (475.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
純度とドキュメンテーション
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データシート (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Yan PS, et al. Cyclo(L-leucyl-L-prolyl) produced by Achromobacter xylosoxidans inhibits aflatoxin production by Aspergillus parasiticus. Appl Environ Microbiol. 2004 Dec;70(12):7466-73. [Content Brief]
[2]. Kim J, et al. Identification of isomeric cyclo(leu-pro) produced by Pseudomonas sesami BC42 and its differential antifungal activities against Colletotrichum orbiculare. Front Microbiol. 2023 Aug 10;14:1230345. [Content Brief]
[3]. Son J, et al. The high-throughput solid-phase extraction of cis-cyclo(L-Leu-L-Pro) and cis-cyclo(L-Phe-L-Pro) from Lactobacillus plantarum demonstrates efficacy against multidrug-resistant bacteria and influenza A (H3N2) virus. Front Mol Biosci. 2024 May 17;11:1346598. doi: 10.3389/fmolb.2024.1346598. Erratum in: Front Mol Biosci. 2025 Apr 15;12:1605848. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7558 mL | 23.7790 mL | 47.5579 mL | 118.8948 mL |
| 5 mM | 0.9512 mL | 4.7558 mL | 9.5116 mL | 23.7790 mL | |
| 10 mM | 0.4756 mL | 2.3779 mL | 4.7558 mL | 11.8895 mL | |
| 15 mM | 0.3171 mL | 1.5853 mL | 3.1705 mL | 7.9263 mL | |
| 20 mM | 0.2378 mL | 1.1889 mL | 2.3779 mL | 5.9447 mL | |
| 25 mM | 0.1902 mL | 0.9512 mL | 1.9023 mL | 4.7558 mL | |
| 30 mM | 0.1585 mL | 0.7926 mL | 1.5853 mL | 3.9632 mL | |
| 40 mM | 0.1189 mL | 0.5945 mL | 1.1889 mL | 2.9724 mL | |
| 50 mM | 0.0951 mL | 0.4756 mL | 0.9512 mL | 2.3779 mL | |
| 60 mM | 0.0793 mL | 0.3963 mL | 0.7926 mL | 1.9816 mL | |
| 80 mM | 0.0594 mL | 0.2972 mL | 0.5945 mL | 1.4862 mL | |
| 100 mM | 0.0476 mL | 0.2378 mL | 0.4756 mL | 1.1889 mL |
Cyclo(L-Leu-L-Pro) 関連分類
HY-P1939 関連分類
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