2873-36-1
Chemical Structure
Cyclo(L-Leu-L-Pro)
Synonym(s): Cyclo(L-prolyl-L-leucyl)
- CAS No.: 2873-36-1
- Formula:C11H18N2O2
- Molecular Weight:210.27
IUPAC Name: (3S,8aS)-3-isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
InChIKey: SZJNCZMRZAUNQT-IUCAKERBSA-N
SMILES: O=C(N1[C@]([H])2CCC1)[C@@H](NC2=O)CC(C)C
Biological Activity: Cyclo(L-Leu-L-Pro) is a cyclic dipeptide with broad-spectrum antibacterial, antiviral and antifungal activities. Its biological activity is highly dependent on the stereoconfiguration and is widely present in microbial metabolites. Cyclo(L-Leu-L-Pro) efficiently and specifically inhibits the production of aflatoxin by Aspergillus flavus. The cis configuration of Cyclo(L-Leu-L-Pro) (cis-cyclo(L-Leu-L-Pro)) has broad-spectrum antibacterial activity against multi-drug resistant bacteria and significantly inhibits the influenza A virus H3N2[1][2][3].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Cyclo(L-Leu-L-Pro) | 99.95% | Cyclo(L-Leu-L-Pro) is a cyclic dipeptide with broad-spectrum antibacterial, antiviral and antifungal activities. Its biological activity is highly dependent on the stereoconfiguration and is widely present in microbial metabolites. Cyclo(L-Leu-L-Pro) efficiently and specifically inhibits the production of aflatoxin by Aspergillus flavus. The cis configuration of Cyclo(L-Leu-L-Pro) (cis-cyclo(L-Leu-L-Pro)) has broad-spectrum antibacterial activity against multi-drug resistant bacteria and significantly inhibits the influenza A virus H3N2. | ||||||||||||||||||||
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References
- [1]. Yan PS, et al. Cyclo(L-leucyl-L-prolyl) produced by Achromobacter xylosoxidans inhibits aflatoxin production by Aspergillus parasiticus. Appl Environ Microbiol. 2004 Dec;70(12):7466-73. [Content Brief]
- [2]. Kim J, et al. Identification of isomeric cyclo(leu-pro) produced by Pseudomonas sesami BC42 and its differential antifungal activities against Colletotrichum orbiculare. Front Microbiol. 2023 Aug 10;14:1230345. [Content Brief]
- [3]. Son J, et al. The high-throughput solid-phase extraction of cis-cyclo(L-Leu-L-Pro) and cis-cyclo(L-Phe-L-Pro) from Lactobacillus plantarum demonstrates efficacy against multidrug-resistant bacteria and influenza A (H3N2) virus. Front Mol Biosci. 2024 May 17;11:1346598. doi: 10.3389/fmolb.2024.1346598. Erratum in: Front Mol Biosci. 2025 Apr 15;12:1605848. [Content Brief]
