1. Peptides
  2. Tyrosylleucine

Tyrosylleucine (Synonyms: Tyr-Leu)

Cat. No.: HY-122794
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Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity.

For research use only. We do not sell to patients.

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Tyrosylleucine Chemical Structure

Tyrosylleucine Chemical Structure

CAS No. : 17355-10-1

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Description

Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity[1].

In Vivo

Tyrosylleucine (YL), administered orally, intracerebroventricularly, or intraperitoneally exhibits a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ddY mice (24-27 g)[1]
Dosage: 0.1-30 mg/kg, i.p.; 0.1-1.0 nmol/mouse, i.c.v.; 30-100 mg/kg, p.o.
Administration: Administered orally, intracerebroventricularly, or intraperitoneally
Result: Decreased immobility time after intraperitoneal (1-30 mg/kg) and intracerebroventricular (0.3-1 nmol/mouse) administrations in the FST.
Exhibited a potent antidepressant-like activity in the forced swim and tail suspension tests in naïve mice.
Molecular Weight

294.35

Formula

C₁₅H₂₂N₂O₄

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (849.33 mM; Need ultrasonic)

DMSO : 250 mg/mL (849.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3973 mL 16.9866 mL 33.9732 mL
5 mM 0.6795 mL 3.3973 mL 6.7946 mL
10 mM 0.3397 mL 1.6987 mL 3.3973 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Tyrosylleucine
Cat. No.:
HY-122794
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