2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Arginyl-Glutamine TFA

Arginyl-Glutamine TFA  (Synonyms: H-Arg-Gln-OH TFA)

Cat. No.: HY-P4253A Purity: 99.22%
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Arginyl-Glutamine TFA is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Arginyl-Glutamine TFA

Arginyl-Glutamine TFA Chemical Structure

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Arginyl-Glutamine TFA:

Arginyl-Glutamine TFA Related Antibodies

Top Publications Citing Use of Products

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Arginyl-Glutamine TFA is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy[1].

IC50 & Target

VEGF[1]
In Vitro

Arginyl-Glutamine TFA (0.5-1.5 mM; 48 h) results in a statistically significant dose-dependent decrease soluble VEGF expression into the culture medium in human RPE cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Arginyl-Glutamine TFA Related Antibodies
In Vivo

Arginyl-Glutamine TFA (1-5 g/kg/day as a hydrochloride salt; i.p.; twice daily) dramatically inhibits retinal neovascularization in the mouse oxygen-induced retinopathy (OIR) model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

644.40

Formula

C17H25F9N6O10
Appearance

Solid

Sequence

Arg-Gln
Sequence Shortening

RQ
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (155.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5518 mL 7.7592 mL 15.5183 mL
5 mM 0.3104 mL 1.5518 mL 3.1037 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5518 mL 7.7592 mL 15.5183 mL 38.7958 mL
5 mM 0.3104 mL 1.5518 mL 3.1037 mL 7.7592 mL
10 mM 0.1552 mL 0.7759 mL 1.5518 mL 3.8796 mL
15 mM 0.1035 mL 0.5173 mL 1.0346 mL 2.5864 mL
20 mM 0.0776 mL 0.3880 mL 0.7759 mL 1.9398 mL
25 mM 0.0621 mL 0.3104 mL 0.6207 mL 1.5518 mL
30 mM 0.0517 mL 0.2586 mL 0.5173 mL 1.2932 mL
40 mM 0.0388 mL 0.1940 mL 0.3880 mL 0.9699 mL
50 mM 0.0310 mL 0.1552 mL 0.3104 mL 0.7759 mL
60 mM 0.0259 mL 0.1293 mL 0.2586 mL 0.6466 mL
80 mM 0.0194 mL 0.0970 mL 0.1940 mL 0.4849 mL
100 mM 0.0155 mL 0.0776 mL 0.1552 mL 0.3880 mL
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Arginyl-Glutamine TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Arginyl-GlutamineH-Arg-Gln-OHVEGFRVascular endothelial growth factor receptoroxygen-induced retinopathyOIR modelhuman RPE cellmouse pupsInhibitorinhibitorinhibit

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