Leucylproline hydrochloride
Based on 1 Customer Validation
Leucylproline hydrochloride (Leu‑Pro hydrochloride) is a dipeptide composed of L‑leucine and L‑proline, and it is a fecal secondary metabolite associated with the gut microbiota. Leucylproline hydrochloride is taken up by Lactococcus lactis cells via the di‑tripeptide transport system, and mediates transcriptional repression of the prtP/prtM promoter after intracellular accumulation. The content of Leucylproline hydrochloride is significantly decreased in fecal samples related to hepatolenticular degeneration. Leucylproline hydrochloride can be used for the study of metabolism‑related diseases.
For research use only. We do not sell to patients.
- Purity : 99.61%
- CAS No.: 87178-63-0
- Formula: C11H21ClN2O3
- Molecular Weight:264.75
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
Leucylproline hydrochloride (2 mM) inhibits the activity of the prtP promoter in Lactococcus lactis MG1363 carrying pNZ544[1].
Leucylproline hydrochloride (1 mM) exerts an immediate, complete, and transient inhibitory effect on the prtP-regulated production of β-glucuronidase in a steady-state glucose-limited continuous culture system of Lactococcus lactis MG1363 (pNZ544)[1].
Leucylproline hydrochloride shows significantly reduced relative abundance in Wilson’s‑disease‑associated fecal metabolome datasets[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 87178-63-0
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Appearance Solid
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Molecular Weight 264.75
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Formula C11H21ClN2O3
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Color White to off-white
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Synonyms
Leu-Pro hydrochloride
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Sequence
Leu-Pro
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Sequence Shortening
LP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 175 mg/mL (661.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 166.67 mg/mL (629.54 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (285 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.7771 mL | 18.8857 mL | 37.7715 mL | 94.4287 mL |
| 5 mM | 0.7554 mL | 3.7771 mL | 7.5543 mL | 18.8857 mL | |
| 10 mM | 0.3777 mL | 1.8886 mL | 3.7771 mL | 9.4429 mL | |
| 15 mM | 0.2518 mL | 1.2590 mL | 2.5181 mL | 6.2952 mL | |
| 20 mM | 0.1889 mL | 0.9443 mL | 1.8886 mL | 4.7214 mL | |
| 25 mM | 0.1511 mL | 0.7554 mL | 1.5109 mL | 3.7771 mL | |
| 30 mM | 0.1259 mL | 0.6295 mL | 1.2590 mL | 3.1476 mL | |
| 40 mM | 0.0944 mL | 0.4721 mL | 0.9443 mL | 2.3607 mL | |
| 50 mM | 0.0755 mL | 0.3777 mL | 0.7554 mL | 1.8886 mL | |
| 60 mM | 0.0630 mL | 0.3148 mL | 0.6295 mL | 1.5738 mL | |
| 80 mM | 0.0472 mL | 0.2361 mL | 0.4721 mL | 1.1804 mL | |
| 100 mM | 0.0378 mL | 0.1889 mL | 0.3777 mL | 0.9443 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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