Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH
Based on 1 Customer Validation
Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH is a dipeptide building block containing a pseudoproline, which is used in studies related to Fmoc solid-phase peptide synthesis. Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH inhibits premature β-sheet aggregation during solid-phase peptide synthesis.
For research use only. We do not sell to patients.
- Purity : 99.74%
- CAS No.: 957780-56-2
- Formula: C31H38N2O8
- Molecular Weight:566.64
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH (Fmoc-Glu (OtBu)-Thr (ΨMe,Me pro)-OH) is incorporated at the Glu11-Thr12 site during microwave-assisted Fmoc-SPPS to reduce β-sheet formation of the peptide in the synthesis of Barrettide A[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 957780-56-2
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Appearance Solid
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Molecular Weight 566.64
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Formula C31H38N2O8
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Color White to off-white
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Sequence
{Fmoc}-{Glu(OtBu)}-{Thr(psi(Me,Me)pro)}
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Sequence Shortening
{Fmoc}-{Glu(OtBu)}-{Thr(psi(Me,Me)pro)}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro
H2O
Peptide Solubility and Storage Guidelines:
1. Calculate the length of the peptide.
2. Calculate the overall charge of the entire peptide according to the following table:
| Contents | Assign value | |
|---|---|---|
| Acidic amino acid | Asp (D), Glu (E), and the C-terminal -COOH. | -1 |
| Basic amino acid | Arg (R), Lys (K), His (H), and the N-terminal -NH2 | +1 |
| Neutral amino acid | Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) | 0 |
3. Recommended solution:
| Overall charge of peptide | Details |
|---|---|
| Negative (<0) |
1. Try to dissolve the peptide in water first. 2. If water fails, add NH4OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide. |
| Positive (>0) |
1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO. |
| Zero (=0) |
1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration. |
Purity & Documentation
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Data Sheet (292 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH Related Classifications
HY-P2399 Related Classifications
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Keywords
- Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH
- 957780-56-2
- Drug Intermediate
- Amino Acid Derivatives
- pseudoproline dipeptide building block
- microwave-assisted Fmoc-SPPS
- total synthesis
- native disulfide connectivity
- correctly folded peptide
- Glu11-Thr12 position
- barrettide A
- Fmoc solid-phase peptide synthesis
- peptide beta-sheet formation
- Inhibitor
- inhibitor
- inhibit