2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. OSu-Val-Cit-PAB-Exa

OSu-Val-Cit-PAB-Exa (compound D) is a cleavable linker-payload conjugate (usable for ADC synthesis). OSu-Val-Cit-PAB-Exa bears an N-terminal N-hydroxysuccinimide (OSu) ester group, and comprises Val-Cit, p-aminobenzyl alcohol (PAB) and Exatecan (HY-13631). OSu-Val-Cit-PAB-Exa serves as a payload-linker intermediate for polypeptide conjugation.

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OSu-Val-Cit-PAB-Exa

OSu-Val-Cit-PAB-Exa Chemical Structure

CAS No. : 3091519-75-1

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OSu-Val-Cit-PAB-Exa Related Antibodies

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Description

OSu-Val-Cit-PAB-Exa (compound D) is a cleavable linker-payload conjugate (usable for ADC synthesis). OSu-Val-Cit-PAB-Exa bears an N-terminal N-hydroxysuccinimide (OSu) ester group, and comprises Val-Cit, p-aminobenzyl alcohol (PAB) and Exatecan (HY-13631). OSu-Val-Cit-PAB-Exa serves as a payload-linker intermediate for polypeptide conjugation[1][2].

Molecular Weight

1052.07

Formula

C52H58FN9O14
CAS No.
SMILES

O=C(CCC1=O)N1OC(CCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OSu-Val-Cit-PAB-Exa Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OSu-Val-Cit-PAB-Exa3091519-75-1Drug-Linker Conjugates for ADCTopoisomerasep-aminobenzyl alcoholexatecanvaline-citrulline dipeptideN-hydroxysuccinimide esterInhibitorinhibitorinhibit

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