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Cat. No.: HY-186185

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OSu-Val-Cit-PAB-Exa

OSu-Val-Cit-PAB-Exa (compound D) is a cleavable linker-payload conjugate (usable for ADC synthesis). OSu-Val-Cit-PAB-Exa bears an N-terminal N-hydroxysuccinimide (OSu) ester group, and comprises Val-Cit, p-aminobenzyl alcohol (PAB) and Exatecan (HY-13631). OSu-Val-Cit-PAB-Exa serves as a payload-linker intermediate for polypeptide conjugation.

For research use only. We do not sell to patients.

CAS No.: 3091519-75-1
Formula: C₅₂H₅₈FN₉O₁₄
Molecular Weight:1052.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

OSu-Val-Cit-PAB-Exa Chemical Structure

CAS No.: 3091519-75-1

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Description

All Drug-Linker Conjugates for ADC Isoforms :

All Topoisomerase Isoforms :

Chemical Information

CAS No. 3091519-75-1
Molecular Weight 1052.07
Formula C₅₂H₅₈FN₉O₁₄
SMILES

O=C(CCC1=O)N1OC(CCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lobba Marco, et al. Tyrosinase-based conjugate compositions and methods of use. WO2025129098A1. 2024-12-13.

[2]. Marco LOBBA, et al. Polypeptide conjugation compositions and methods of use. WO2025059190A2. 2024-09-11.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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OSu-Val-Cit-PAB-Exa

All Drug-Linker Conjugates for ADC Isoforms

All Topoisomerase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

OSu-Val-Cit-PAB-Exa Related Classifications

HY-186185 Related Classifications