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Results for "

elastase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Elastase (97) Akt (1) Amino Acid Derivatives (1) AMPK (2) Antibiotic (1) Apoptosis (3) Autophagy (1) Bacterial (17) Bcl-2 Family (1) Beta-lactamase (1) Biochemical Assay Reagents (3) Caspase (1) Cathepsin (4) CFTR (1) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (1) Drug Derivative (2) Drug Intermediate (1) Drug Metabolite (1) Endogenous Metabolite (2) ERK (1) Factor VIII (1) Factor Xa (1) Factor XI (1) Fc Receptor (FcR) (1) Fluorescent Dye (4) Formyl Peptide Receptor (FPR) (3) FOXJ (1) Furin (1) Glutathione S-transferase (1) HCV (1) HCV Protease (1) Heme Oxygenase (HO) (1) Integrin (1) Interleukin Related (3) Isotope-Labeled Compounds (1) Kallikrein (1) Leukotriene Receptor (2) Lipoxygenase (2) MicroRNA (1) MMP (1) mRNA (2) mTOR (1) NF-κB (4) NOD-like Receptor (NLR) (1) p38 MAPK (1) Parasite (1) Phosphodiesterase (PDE) (1) PI3K (1) Platelet-activating Factor Receptor (PAFR) (3) Protease Activated Receptor (PAR) (1) Proteasome (2) PSMA (1) Reactive Oxygen Species (ROS) (3) Reference Standards (8) SARS-CoV (5) Ser/Thr Protease (15) Sirtuin (1) SOD (1) STING (1) Thrombin (2) TNF Receptor (1) TRP Channel (1) Tyrosinase (1) Xanthine Oxidase (2)
By Research Areas:	Cancer (25) Cardiovascular Disease (8) Infection (27) Inflammation/Immunology (80) Metabolic Disease (8) Neurological Disease (5)
Oligonucleotides:	Solvents (1) CpG ODNs (1) mRNA (2)

159

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Elastase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2974

Elastase, Porcine pancreas 4 Publications Verification EC 3.4.21.36; Pancreatopeptidase E	Elastase	Metabolic Disease
Elastase, Porcine pancreas (EC 3.4.21.36) is a single polypeptide chain of 240 amino acid residues, derived from pig pancreas. Elastase, Porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters .

HY-136865

MeOSuc-AAPV-AMC	Fluorescent Dye	Others
MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (K_m: 362 μM, Ex=380 nm, Em=460 nm) .

HY-15651

Alvelestat 10+ Cited Publications AZD9668	Elastase	Inflammation/Immunology
Alvelestat (AZD9668) is an orally bioavailable, affinity and selective inhibitor of *neutrophil elastase* (NE) with a pIC₅₀ value of 7.9 nM, a K_i value of 9.4 nM and a K_d** value of 9.5 nM .

HY-75957

DMP 777 5 Publications Verification L-694458	Elastase	Inflammation/Immunology
DMP 777 is a potent, selective, and orally active *human leukocyte elastase* (HLE)** inhibitor.

HY-147140

BOS-318 2 Publications Verification	Furin	Inflammation/Immunology
BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC₅₀ value of 1.9 nM. BOS-318 protects ENaC from subsequent activation by neutrophil elastase. BOS-318 can be used for the rsearch for CF lung disease .

HY-P2685

MeOSuc-Ala-Ala-Pro-Val-pNA	Fluorescent Dye	Others
MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive chromogenic substrate for human leukocyte and porcine pancreatic elastase .

HY-15891A

GW311616 hydrochloride 10+ Cited Publications GW311616A	Elastase	Inflammation/Immunology
GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC₅₀ value of 22 nM and K_i value of 0.31 nM .

HY-19406

AE-3763	Elastase	Cardiovascular Disease Inflammation/Immunology
AE-3763 is a peptide-based human neutrophil elastase inhibitor with an IC₅₀ of 29 nM.

HY-103445

SSR69071	Elastase	Cardiovascular Disease
SSR69071 is a potent, orally active and selective inhibitor of neutrophil elastase. SSR69071 reduces myocardial infarct size following ischemia-reperfusion injury . SSR69071 displays a higher affinity for human elastase (K_i=0.0168 nM) than for rat (K_i=3 nM), mouse (K_i=1.8 nM), and rabbit (K_i= 58 nM) elastases .

HY-15652

Freselestat ONO-6818; ONO-PO-736	Elastase	Inflammation/Immunology
Freselestat (ONO-6818) is a potent and orally active neutrophil elastase inhibitor with a K_i of 12.2 nM. Freselestat is >100-fold less-active against other proteases such as trypsin, protein-ase 3, pancreatic elastase, plasmin, thrombin, collagenase, cathepsin G, and murine macrophage elastase. Freselestat has a potent anti-inflammatory activity .

HY-19908

BAY-85-8501 3 Publications Verification	Elastase	Metabolic Disease
BAY-85-8501 is a selective, reversible and potent inhibitor of *Human Neutrophil Elastase* (HNE), with an IC₅₀** of 65 pM.

HY-136888

MeOSuc-AAPV-CMK elastase Inhibitor III	Elastase Cathepsin	Others
MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an *elastase* inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase .

HY-155414

*Neutrophil elastase* inhibitor 5**	Elastase Ser/Thr Protease Sirtuin	Inflammation/Immunology
Neutrophil elastase inhibitor 5 is an inhibitor of human neutrophil elastase (HNE), proteinase 3 (PR3) and sirt2, with IC₅₀ values of 4.91, 20.69 and 2.42 μM, respectively. Neutrophil elastase inhibitor 5 inhibits superoxide anion production and elastase release in human neutrophils. Neutrophil elastase inhibitor 5 can be used for the research of neutrophil inflammatory diseases .

HY-111457A

BAY-678 1 Publications Verification	Elastase	Inflammation/Immunology
BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC₅₀ of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).

HY-118177

*Neutrophil elastase* inhibitor 1**	Elastase Thrombin Ser/Thr Protease	Inflammation/Immunology
Neutrophil elastase inhibitor 1 is a competitive, pseudo-reversible inhibitor of human neutrophil elastase (HNE) with an IC₅₀ of 7 nM. Neutrophil elastase inhibitor 1 also exhibits inhibitory activity against thrombin, chymotrypsin and urokinase, with IC₅₀ values of 1.9 μM, 66 nM and 6.6 μM, respectively. Neutrophil elastase inhibitor 1 can be used in research related to acute respiratory distress syndrome, chronic obstructive pulmonary disease and other conditions .

HY-W104758

Elastase-IN-3	Elastase Antibiotic Bacterial	Others
Elastase-IN-3 (Compound 2i) is an *Elastase* inhibitor of Pseudomonas aeruginosa. Elastase-IN-3 inhibits the quorum sensing system of Pseudomonas aeruginosa by targeting the LasR protein (K_D value of 7.04 M), thereby preventing food spoilage caused by Pseudomonas aeruginosa .

HY-124061

GB83	Protease Activated Receptor (PAR)	Neurological Disease Inflammation/Immunology
GB83 is a potent PAR2 antagonist. GB83 reverses neutrophil elastase‐induced synovitis and pain. GB83 blocks the effect of MET-1 supernatant on NG neurons .

HY-19254

ZD-0892	Elastase	Cardiovascular Disease
ZD-0892 is a selective and potent inhibitor of a neutrophil elastase with K_is of 6.7 and 200 nM for human neutrophil elastase and porcine pancreatic elastase, respectively.

HY-19269

FK706	Elastase	Inflammation/Immunology
FK706 is a potent, slow-binding and competitive inhibitor of human neutrophil elastase with an IC₅₀ of 83 nM and a K_i of 4.2 nM. FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase with IC₅₀s of 22 nM and 100 nM, respectively, and has no inhibitory activity against other serine proteinases such as human pancreatic trypsin, human pancreatic α-chymotrypsin and human leukocyte cathepsin G. FK706 has anti-inflammatory effect .

HY-P4476

Suc-AAPA-pNA 1 Publications Verification	Ser/Thr Protease	Others
Suc-AAPA-pNA is a substrate for chymotrypsin A and elastase. Suc-AAPA-pNA can be used for enzyme activity assay .

HY-132132

*Neutrophil elastase* inhibitor 3**	Elastase	Inflammation/Immunology
Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a *neutrophil elastase* (NE) inhibitor, with an IC₅₀** of 80.8 nM for NE release .

HY-N2395

Chrysophanol 8-O-glucoside 1 Publications Verification	Elastase	Cancer
Chrysophanol 8-O-glucoside, from the roots of Rumex acetosa, shows moderate *elastase* inhibition activity .

HY-P3293

Lonodelestat POL6014	Elastase	Inflammation/Immunology
Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of *human neutrophil elastase* (hNE)**. Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF) .

HY-162779

CDD-3290	PSMA Elastase	Others
CDD-3290 (Compound 20) is a prostate-specific antigen (PSA) inhibitor with a K_i value of 216 nM. CDD-3290 also inhibits α-chymotrypsin and elastase .

HY-N10450

Kumujian A 1-Ethoxycarbonyl-β-carboline	Reactive Oxygen Species (ROS)	Inflammation/Immunology
Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC₅₀ = 4.87 μg/mL) and elastase release (IC₅₀ = 6.29 μg/mL) .

HY-P2922

Cathepsin C	Cathepsin	Cancer
Cathepsin C is a lysosomal cysteine protease essential for catalytic activation of many serine proteases, including proteinase 3 (PR3), neutrophil elastase (NE), cathepsin G (CTSG), granzyme A/B/C, and mast cell chymase .

HY-N8164

19α-Hydroxyasiatic acid	Elastase	Inflammation/Immunology
19α-Hydroxyasiatic acid, a natural triterpenoid, possesses anti-elastase activity .

HY-U00256

ZD8321	Elastase	Inflammation/Immunology Cancer
ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) with a K_i of 13±1.7 nM.

HY-15891

GW311616	Elastase	Inflammation/Immunology
GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC₅₀ value of 22 nM and K_i value of 0.31 nM .

HY-B0149S1

Tranexamic acid-d2-1	Isotope-Labeled Compounds	Cancer
Tranexamic acid-d₂-1 is the deuterium labeled Tranexamic acid . Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC₅₀ of 5 mM .

HY-163411

*Neutrophil elastase* inhibitor 6**	Elastase Ser/Thr Protease	Inflammation/Immunology
Neutrophil elastase inhibitor 6 is a dual inhibitor of human neutrophil elastase (HNE) and proteinase 3 (PR3), with high selectivity for cathepsin G. Neutrophil elastase inhibitor 6 can be used in the research of chronic neutrophilic inflammatory diseases .

HY-155231

*Neutrophil elastase* inhibitor 4**	Elastase Apoptosis	Cancer
Neutrophil elastase inhibitor 4 is a human neutrophil elastase (HNE) inhibitor with an IC₅₀ of 21.78 nM and a K_i of 8.04 nM. Neutrophil elastase inhibitor 4 induces G₂/M cell cycle arrest and apoptosis. Neutrophil elastase inhibitor 4 is applicable to research related to breast cancer, multiple myeloma and non-small cell lung cancer .

HY-117668

MDL 101146	Elastase	Infection Inflammation/Immunology
MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a K_i value of 25 nM. MDL 101146 can be used for the research of arthritis .

HY-123791

AZD-9819	Elastase	Inflammation/Immunology
AZD-9819 is a *neutrophil elastase* (HNE)** inhibitor. AZD-9819 can be used to study chronic obstructive pulmonary disease .

HY-100240

Lodelaben SC-39026; Declaben	Elastase	Cardiovascular Disease Metabolic Disease
Lodelaben is a human neutrophil *elastase* inhibitor with an IC₅₀ and K_i of 0.5 and 1.5 μM, respectively.

HY-P3106

(Z-Ala-Ala-Ala-Ala)2Rh110 (Z-Ala-Ala-Ala-Ala)2Rhodamine110; bis-CBZ-L-alanyl-L-arginine amide Rhodamine 110	Fluorescent Dye	Others
(Z-Ala-Ala-Ala-Ala)2Rh110 is a sensitive fluorogenic elastase substrate. The colorless and nonfluorescent (Z-Ala-Ala-Ala-Ala)2Rh110 is selectively cleaved by elastase to yield the highly fluorescent compound rhodamine 110, which can be analyzed with an excitation wavelength of 485 nm and emission wavelength of 525 nm.

HY-P3293A

Lonodelestat TFA POL6014 TFA	Elastase	Inflammation/Immunology
Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of *human neutrophil elastase* (hNE)**. Lonodelestat TFA has the potential for the research of cystic fibrosis (CF) .

HY-P4126

Suc-Ala-Ala-Pro-Val-AMC	Elastase	Others
Suc-Ala-Ala-Pro-Val-AMC is a fluorescent substrate for *elastase. Suc-Ala-Ala-Pro-Val-AMC can be hydrolyzed by these elastases* to release the fluorescent substance 7-amino-4-methylcoumarin. Suc-Ala-Ala-Pro-Val-AMC is used for in vitro elastase activity assays and can also be applied in studies related to chronic wounds .

HY-15651A

Alvelestat tosylate AZD9668 tosylate	Elastase	Inflammation/Immunology
Alvelestat (tosylate) is an orally bioavailable, affinity and selective inhibitor of *neutrophil elastase* (NE) with a pIC₅₀ value of 7.9 nM, a K_i value of 9.4 nM and a K_d** value of 9.5 nM .

HY-P5459

Elafin(human)	Bacterial Elastase	Infection
Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil *elastase* (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus .

HY-P11337

Scyptolin B	Endogenous Metabolite Elastase	Others
Scyptolin B, a cyclic depsipeptides, is a secondary metabolite. Scyptolin B can be isolated from axenic cultures of Scytonema hofmanni PCC 7110. Scyptolin B selective inhibits porcine pancreatic *Elastase* with an IC₅₀ of 3.1 μg/mL .

HY-107965

Safflower oil (from Carthamus tinctorius seed) Safflower seed oil (from Carthamus tinctorius seed)	Biochemical Assay Reagents Elastase	Inflammation/Immunology
Safflower oil (from Carthamus tinctorius seed) is rich in unsaturated fatty acids such as linoleic acid and oleic acid, as well as tocopherols and phenolic compounds, and exhibits antioxidant, anti-aging and blood lipid-regulating effects. Safflower oil (from Carthamus tinctorius seed) inhibits the activities of collagenase and *elastase, and exerts antioxidant activity by scavenging free radicals. Linoleic acid in safflower oil (from Carthamus tinctorius* seed) reduces blood cholesterol levels. Safflower oil (from Carthamus tinctorius seed) can be applied to research in fields such as skin aging, atherosclerosis, edible oil processing and industrial raw material development .

HY-106293

ICI-200880	Elastase	Inflammation/Immunology
ICI-200880 is a potent, selective and reversible human neutrophil elastase (HNE) inhibitor. ICI-200880 is promising for research of inflammatory lung diseases related to neutrophil elastase, such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) .

HY-P5374

MeOSuc-AAPV-AFC	Elastase	Others
MeOSuc-AAPV-AFC is a biological active peptide. (A highly specific neutrophil elastase substrate, Abs/Em=380/500 nm.)

HY-N6876

Secologanoside	Elastase	Neurological Disease
Secologanoside is a triterpenoid isolated from Poraqueiba sericea, weakly inhibits *elastase* with an IC₅₀ of 164 μg/mL. Secologanoside is moderate cytotoxic to fibroblasts .

HY-171888

BI-9740	Cathepsin Elastase	Inflammation/Immunology
BI-9740 is an orally active and selective cathepsin C (CatC) inhibitor, with an IC₅₀ of 0.6 nM in mice and 2.6 nM in rats. BI-9740 can inhibit the production of active neutrophil elastase. Additionally, BI-9740 is capable of reducing the activities of neutrophil elastase and cathepsin G in the bone marrow of rats, alleviating pathological damage to grafts after heart transplantation, shortening the reperfusion time, and improving left ventricular function. BI-9740 can be used in research related to organ transplantation .

HY-146070

Elastase-IN-1	Elastase	Inflammation/Immunology Cancer
Elastase-IN-1 (Compound Q11) is an *elastase* inhibitor with an IC₅₀ of 0.897 µM. Elastase-IN-1 is non-toxic .

HY-E70586

Elastase (high purity)	Ser/Thr Protease	Others
Elastase (high purity) is a serine protease that hydrolyzes proteins and peptides.

HY-124556

Elasnin	Elastase	Inflammation/Immunology
Elasnin is a selective granulocyte elastase inhibitor. Elasnin is almost ineffective for pancreatic elastase, trypsin, chymotrypsin, thermolysin and papain .

HY-105382

L 683845	Others	Others
L-683845 is an orally active inhibitor of human leukocyte elastase. L-683845 can be used in the research of physiological and pathological processes related to human leukocyte elastase .

Cat. No.	Product Name	Type

HY-136865

MeOSuc-AAPV-AMC	Fluorescent Dyes
MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (K_m: 362 μM, Ex=380 nm, Em=460 nm) .

HY-P2685

MeOSuc-Ala-Ala-Pro-Val-pNA	Fluorescent Dyes
MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive chromogenic substrate for human leukocyte and porcine pancreatic elastase .

Cat. No.	Product Name	Type

HY-W008753

Z-L-Val-OH N-Cbz-L-valine	Biochemical Assay Reagents
Z-L-Val-OH (N-Cbz-L-valine) is an amino acid derivative and key intermediate in organic synthesis. Z-L-Val-OH can be used in the synthesis of anti-cytomegalovirus compounds and peptide inhibitors of human spleen plasminogen activator (SFP) and human leukocyte elastase-like protease (ELP) .

HY-107965

Safflower oil (from Carthamus tinctorius seed)

Safflower seed oil (from Carthamus tinctorius seed)

Biochemical Assay Reagents

Safflower oil (from Carthamus tinctorius seed) is rich in unsaturated fatty acids such as linoleic acid and oleic acid, as well as tocopherols and phenolic compounds, and exhibits antioxidant, anti-aging and blood lipid-regulating effects. Safflower oil (from Carthamus tinctorius seed) inhibits the activities of collagenase and elastase, and exerts antioxidant activity by scavenging free radicals. Linoleic acid in safflower oil (from Carthamus tinctorius seed) reduces blood cholesterol levels. Safflower oil (from Carthamus tinctorius seed) can be applied to research in fields such as skin aging, atherosclerosis, edible oil processing and industrial raw material development .

Cat. No.	Product Name	Target	Research Area

HY-136865

MeOSuc-AAPV-AMC	Fluorescent Dye	Others
MeOSuc-AAPV-AMC is a fluorogenic substrate for human leukocyte and porcine pancreatic elastase (K_m: 362 μM, Ex=380 nm, Em=460 nm) .

HY-P2685

MeOSuc-Ala-Ala-Pro-Val-pNA	Fluorescent Dye	Others
MeOSuc-Ala-Ala-Pro-Val-pNA is a sensitive chromogenic substrate for human leukocyte and porcine pancreatic elastase .

HY-136888

MeOSuc-AAPV-CMK elastase Inhibitor III	Elastase Cathepsin	Others
MeOSuc-AAPV-CMK (Elastase Inhibitor III) is an *elastase* inhibitor. MeOSuc-AAPV-CMK also inhibits cathepsin G and proteinase 3.MeOSuc-AAPV-CMK blocks the cleavage of adiponectin by leukocyte elastase .

HY-P4476

Suc-AAPA-pNA 1 Publications Verification	Ser/Thr Protease	Others
Suc-AAPA-pNA is a substrate for chymotrypsin A and elastase. Suc-AAPA-pNA can be used for enzyme activity assay .

HY-137409

Suc-AAA-pNA	Peptides	Others
Suc-AAA-pNA is a hydrolyzable peptide substrate. Suc-AAA-pNA serves as a chromogenic substrate for porcine pancreatic elastase, and undergoes hydrolysis via a virtual transition state with a minor physical step and a dominant chemical step, thereby forming a stable reactant state .

HY-P3293

Lonodelestat POL6014	Elastase	Inflammation/Immunology
Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of *human neutrophil elastase* (hNE)**. Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF) .

HY-P10868

Pegtarazimod RLS-0071	Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Pegtarazimod (RLS-0071) is a dual-target anti-inflammatory peptide that exerts its effects by simultaneously regulating the complement system and neutrophil-associated inflammatory pathways. Pegtarazimod reduces ROS production both in vitro and in vivo, and decreases the level of neutrophil elastase, a marker of neutrophil extracellular traps (NETs), in vivo, thereby alleviating inflammatory responses. Pegtarazimod significantly improves the survival rate of mice in multiple in vivo models of acute graft-versus-host disease (aGVHD). Pegtarazimod inhibits the activation of the C1 complex, reduces the herpes zoster-like spread of herpes simplex virus type 1 skin infection, and improves the survival rate of infected mice . Pegtarazimod can be used in research related to acute graft-versus-host disease, acute pulmonary diseases, and skin herpes simplex virus type 1 infection .

HY-P10143

MMP-2/MMP-9 Substrate Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	MMP	Others
MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties .

HY-P3106

(Z-Ala-Ala-Ala-Ala)2Rh110 (Z-Ala-Ala-Ala-Ala)2Rhodamine110; bis-CBZ-L-alanyl-L-arginine amide Rhodamine 110	Fluorescent Dye	Others
(Z-Ala-Ala-Ala-Ala)2Rh110 is a sensitive fluorogenic elastase substrate. The colorless and nonfluorescent (Z-Ala-Ala-Ala-Ala)2Rh110 is selectively cleaved by elastase to yield the highly fluorescent compound rhodamine 110, which can be analyzed with an excitation wavelength of 485 nm and emission wavelength of 525 nm.

HY-P3293A

Lonodelestat TFA POL6014 TFA	Elastase	Inflammation/Immunology
Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of *human neutrophil elastase* (hNE)**. Lonodelestat TFA has the potential for the research of cystic fibrosis (CF) .

HY-P4669

LM-030 BPR277	Kallikrein Elastase	Inflammation/Immunology
LM-030 (BPR277), cyclic depsipeptide, is a potent kallikrein-related peptidase 7 (KLK7) and human neutrophil *elastase* inhibitor with IC₅₀ values of 1 and 10 nM. LM-030 can be used for the study of Netherton syndrome .

HY-P4126

Suc-Ala-Ala-Pro-Val-AMC	Elastase	Others
Suc-Ala-Ala-Pro-Val-AMC is a fluorescent substrate for *elastase. Suc-Ala-Ala-Pro-Val-AMC can be hydrolyzed by these elastases* to release the fluorescent substance 7-amino-4-methylcoumarin. Suc-Ala-Ala-Pro-Val-AMC is used for in vitro elastase activity assays and can also be applied in studies related to chronic wounds .

HY-P5459

Elafin(human)	Bacterial Elastase	Infection
Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil *elastase* (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus .

HY-P11337

Scyptolin B	Endogenous Metabolite Elastase	Others
Scyptolin B, a cyclic depsipeptides, is a secondary metabolite. Scyptolin B can be isolated from axenic cultures of Scytonema hofmanni PCC 7110. Scyptolin B selective inhibits porcine pancreatic *Elastase* with an IC₅₀ of 3.1 μg/mL .

HY-P5374

MeOSuc-AAPV-AFC	Elastase	Others
MeOSuc-AAPV-AFC is a biological active peptide. (A highly specific neutrophil elastase substrate, Abs/Em=380/500 nm.)

HY-P5995

MeOSuc-AAPA-CMK	Elastase	Cancer
MeOSuc-AAPA-CMK is a potent inhibitor of human neutrophil *elastase* .

HY-P3648

Ala-Ala-Pro-Val-chloromethylketone AAPV-CMK	Elastase	Inflammation/Immunology
Ala-Ala-Pro-Val-chloromethylketone is an irreversible human neutrophil elastase (NE) inhibitor for use in the study of chronic inflammatory airway diseases .

HY-126785

Suc-AAP-Abu-pNA Colorimetric elastase Substrate	Elastase	Others
Suc-AAP-Abu-pNA (Colorimetric Elastase Substrate) is a specific substrate for pancreatic elastase (K_m = 100 μM; K_cat/K_m = 35,300 s ^-1 M ^-1 for rat pancreatic elastase; K_m = 30 μM; K_cat/K_m = 351,000 s ^-1 M ^-1 for porcine pancreatic elastase). Suc-AAP-Abu-pNA also promotes OPC migration .

HY-P10924

Roseltide rT1	Elastase	Metabolic Disease
Roseltide rT1 is a neutrophil *elastase* inhibitor (IC₅₀=0.47 μM) rich in cysteine and one of the Roseltide (rT1-rT8) family members. Roseltide rT1 improves cAMP accumulation stimulated by neutrophil elastase in vitro, showing potential for inhibiting related diseases .

HY-P5993

MeOSuc-Ala-Ala-Pro-Val-4-MNA	Fluorescent Dye	Others
MeOSuc-Ala-Ala-Pro-Val-4-MNA is a *elastase* fluorogenic substrate that can be detected at 425 nm (with excitation at 340 nm) .

HY-16707

CH 5450 Z-Ile-Glu-Pro-Phe-Ome	Proteasome	Inflammation/Immunology
CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a selective short peptide human cardiac chymase inhibitor. CH-5450 inhibits the action of rat MAB elastase 2 on substrate Ang I with an IC₅₀ value of 49 µM and N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide with an IC₅₀ value of 4.8 µM .

HY-P4350

Suc-Ala-Ala-Ala-AMC	Elastase	Others
Suc-Ala-Ala-Ala-AMC is a peptide substrate of elastase or elastase-like .

HY-P4362

Suc-Ala-Pro-Ala-AMC	Elastase	Others
Suc-Ala-Pro-Ala-AMC is a tripeptide substrate of elastase .

HY-P4489

Suc-AAPM-pNA	Peptides	Others
Suc-AAPM-pNA is a sensitive substrate for the determination of human pancreatic elastase activity .

HY-P4346

MeOSuc-Ala-Ala-Pro-Met-AMC	Elastase	Others
MeOSuc-Ala-Ala-Pro-Met-AMC is a peptide substrate of elastases and chymotrypsin-like serine peptidases .

HY-P2033

Nostopeptin B	Elastase Ser/Thr Protease	Inflammation/Immunology
Nostopeptin B is a cyclic dipeptide that can be isolated from N. minutum (NIES-26). The structure of Nostopeptin B contains Ahp (3-amino-6-hydroxy-2-piperidone), which exhibits effective inhibition against *elastase* and chymotrypsin .

HY-125128

Glp-Pro-Val-pNA	Biochemical Assay Reagents	Others
Glp-Pro-Val-pNA is a granulocyte elastase substrate. Glp-Pro-Val-pNA can be used to quantify the release of elastase .

HY-P11787

Eglin c (60-63)	Elastase	Inflammation/Immunology
Eglin c (60-63) is a selective *Elastase* inhibitor, with a K_i value of 2.3e-3 M against human leukocyte hElastase and a K_i value of 4.8e-3 M against porcine pancreatic Elastase. Eglin c (60-63) can be used in research related to rheumatoid arthritis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991998

Anti-Human/Monkey CD16a Antibody (3G8)	Fc Receptor (FcR)	Inflammation/Immunology Cancer
Anti-Human/Monkey CD16a Antibody (3G8) is a monoclonal antibody targeting CD16a. Anti-Human/Monkey CD16a Antibody (3G8) blocks FcγRIII/CD16a, upregulates the metabolic activity of CD16+ cells, downregulates CD87, a poor prognostic marker, and inhibits the engraftment and growth of leukemia cells in acute myeloid leukemia, and rapidly increases platelet counts in immune thrombocytopenia. Anti-Human/Monkey CD16a Antibody (3G8) is applicable to research related to tumor immunology .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0616

Trifolirhizin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Plants Trifolium pratense Linn. Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology Other Flavonoids Source Classification Cancer	Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB
Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC₅₀ value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders .

HY-N1942

5-O-Demethylnobiletin 3 Publications Verification 5-Demethylnobiletin	Flavonoids Classification of Application Fields Neurological Disease Flavones Rutaceae Plants Disease Research Fields Citrus Cancer	Lipoxygenase Leukotriene Receptor
5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB₄) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM .

HY-N2472

Medicagenic acid Castanogenin	Infection Triterpenes Classification of Application Fields Herniaria glabra Linnaeus. Terpenoids Plants Disease Research Fields Caryophyllaceae	Bacterial Xanthine Oxidase
Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes . Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE .

HY-N13250

Hawthorn Extract	Cardiovascular Disease Classification of Application Fields Rosaceae Plants Disease Research Fields Source Classification	Apoptosis AMPK Elastase Bcl-2 Family Interleukin Related Caspase PI3K Akt SOD
Hawthorn Extract is an orally active hawthorn extract. Hawthorn Extract decreases Bax expression and increases Bcl-2 expression in the aorta. Hawthorn Extract regulates the AMPK signaling pathway, induces apoptosis, enhances the hepatic antioxidant system, and ameliorates symptoms of liver injury, inflammation and cancer. Hawthorn Extract reduces plasma levels of pro-inflammatory factors, increases plasma levels of anti-inflammatory adiponectin, and alleviates atherosclerotic plaque lesions in the aorta. Hawthorn Extract improves symptoms associated with chronic heart failure . Hawthorn Extract inhibits FMLP-induced superoxide anion production, *Elastase* release, ILB₄ generation and calcium signaling in neutrophils, and also reduces LPS-induced cytokine production in neutrophils. Hawthorn Extract induces autophagy and inhibits the proliferation of intestinal stem cells. Hawthorn Extract can be used in research related to atherosclerosis, hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, hepatocellular carcinoma, chronic heart failure and hypotension .

HY-N2395

Chrysophanol 8-O-glucoside 1 Publications Verification	Quinones Monophenols Classification of Application Fields Rheum palmatum L. Polygonaceae Anthraquinones Phenols Plants Disease Research Fields Source Classification Cancer	Elastase
Chrysophanol 8-O-glucoside, from the roots of Rumex acetosa, shows moderate *elastase* inhibition activity .

HY-N10450

Kumujian A 1-Ethoxycarbonyl-β-carboline	Alkaloids Simaroubaceae Plants Picrasma quassioides(D．Don)Benn． Source Classification Indole Alkaloids	Reactive Oxygen Species (ROS)
Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC₅₀ = 4.87 μg/mL) and elastase release (IC₅₀ = 6.29 μg/mL) .

HY-N8164

19α-Hydroxyasiatic acid	Triterpenes Classification of Application Fields Terpenoids Plants Symplocos chinensis (Lour.) Druce Disease Research Fields Inflammation/Immunology Symplocaceae Source Classification	Elastase
19α-Hydroxyasiatic acid, a natural triterpenoid, possesses anti-elastase activity .

HY-N1235

Skullcapflavone I Panicolin	Flavonols Flavonoids Labiatae Plants Medicago truncatula Gaertn. Source Classification	Elastase MicroRNA
Skullcapflavone I can be isolated from A. nallamalayana. Skullcapflavone I inhibits collagenase and *elastase* enzyme with IC₅₀s of 106.74 μM and 186.70 μM. Skullcapflavone I has anticancer activities by down-regulating miR-23a .

HY-N6876

Secologanoside	other families Iridoids Terpenoids Plants Source Classification	Elastase
Secologanoside is a triterpenoid isolated from Poraqueiba sericea, weakly inhibits *elastase* with an IC₅₀ of 164 μg/mL. Secologanoside is moderate cytotoxic to fibroblasts .

HY-N8152

Randialic acid B	Aquifoliaceae Triterpenes Classification of Application Fields Terpenoids Plants Disease Research Fields Inflammation/Immunology Tabernaemontana elegans Stapf Source Classification	Reactive Oxygen Species (ROS)
Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo .

HY-N3566

Cepharadione A	Structural Classification Alkaloids Liliaceae Piper betle L. Piperaceae Allium cepa L. Quinoline Alkaloids Plants Source Classification	Others
Cepharadione A can be isolated from the roots of Piper betle Linn. Cepharadione A inhibits FMLP/CB induced elastase release by human neutrophils .

HY-100397

Elastatinal	Source Classification	Elastase
Elastatinal is a potent and competitive inhibitor of *elastase, with a K_i* of 0.21 μM. Elastatinal more potently inhibits pancreatic elastase versus leucocyte elastase. Elastatinal shows no activity on human leucocyte chymotrypsin-like protease .

HY-130294

Pyracrenic acid	Terpenoids Pyracantha crenulata (D. Don) Roem. Rosaceae Diterpenoids Plants Source Classification	Elastase
Pyracrenic acid is an *elastase* inhibitor (IC₅₀ = 2.42 µM), can be obtained from the bark of Pyracantha crenulata. Pyracrenic acid has DPPH free radical scavenging activity and anti-inflammatory activity .

HY-N2472R

Medicagenic acid (Standard) Castanogenin (Standard)	Structural Classification Triterpenes Herniaria glabra Linnaeus. Terpenoids Plants Caryophyllaceae	Xanthine Oxidase Reference Standards Bacterial
Medicagenic acid (Standard) is the analytical standard of Medicagenic acid. This product is intended for research and analytical applications. Medicagenic acid (Castanogenin) is isolated from the roots of Herniaria glabra, exhibits potent fungistatic effects against several plant pathogens and human dermatophytes . Medicagenic acid (Castanogenin) has low enzyme inhibitory activities, the target enzymes are xanthine oxidase, collagenase, elastase, tyrosinase, ChE .

HY-N2395R

Chrysophanol 8-O-glucoside (Standard)	Structural Classification Quinones Monophenols Rheum palmatum L. Polygonaceae Anthraquinones Phenols Plants Source Classification	Reference Standards Elastase
Chrysophanol 8-O-glucoside (Standard) is the analytical standard of Chrysophanol 8-O-glucoside. This product is intended for research and analytical applications. Chrysophanol 8-O-glucoside, from the roots of Rumex acetosa, shows moderate elastase inhibition activity .

HY-N4330

Rivulariapeptolides 1155	Natural Products Microorganisms Source Classification	Ser/Thr Protease
Rivulariapeptolides 1155 is a potent serine protease inhibitor with IC₅₀s of 41.84, 4.94, 56.54 nM for chymotrypsin, elastase, prpteinase K, respectively .

HY-N8604

Methyl 4-O-caffeoylquinate	Aquifoliaceae Phenols Polyphenols Plants Tabernaemontana pandacaqui Lam. Source Classification	Others
Methyl 4-O-caffeoylquinate is an extract naturally derived from the leaf ofIlex paraguariensis. Methyl 4-O-caffeoylquinate has human neutrophilic elastase (HNE) inhibitory activity .

HY-N4332

Rivulariapeptolides 1121	Natural Products Microorganisms Source Classification	Ser/Thr Protease
Rivulariapeptolides 1121 is a high potent and selective serine protease inhibitor with IC₅₀ values of 35.52 nM, 13.24 nM and 48.05 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-N4331

Rivulariapeptolides 1185	Natural Products Microorganisms Source Classification	Ser/Thr Protease
Rivulariapeptolides 1185 is a high potent and selective serine protease inhibitor with IC₅₀ values of 13.17 nM, 23.59 nM and 55.26 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-N4333

Rivulariapeptolides 988	Natural Products Microorganisms Source Classification	Ser/Thr Protease
Rivulariapeptolides 988 is a high potent and selective serine protease inhibitor with IC₅₀ values of 95.46 nM, 15.29 nM and 85.50 nM for chymotrypsin, elastase and proteinase K, respectively .

HY-N11564

Aristololactam IIIa	Alkaloids Pyrrole Alkaloids Aristolochia manshuriensis Kom Plants Aristolochiaceae Source Classification	Elastase
Aristololactam IIIa exhibits significant inhibitory effects on superoxide anion generation and elastase release with IC₅₀ values of 0.12 and 0.20 μg/mL, respectively .

HY-N8447

3'-O-Methylmurraol	Carlina acaulis L. Coumarins Phenylpropanoids Plants Umbelliferae Source Classification	Others
3'-O-Methylmurraol is a coumarinthat can be found in Cnidium monnieri. 3'-O-Methylmurraol inhibits superoxide radical anion generation and elastase release .

HY-N6876R

Secologanoside (Standard)	Structural Classification other families Iridoids Terpenoids Plants Source Classification	Reference Standards Elastase
Secologanoside (Standard) is the analytical standard of Secologanoside. This product is intended for research and analytical applications. Secologanoside is a triterpenoid isolated from Poraqueiba sericea, weakly inhibits elastase with an IC₅₀ of 164 μg/mL. Secologanoside is moderate cytotoxic to fibroblasts .

HY-P2033

Nostopeptin B	Natural Products Marine algae Marine natural products Source Classification	Elastase Ser/Thr Protease
Nostopeptin B is a cyclic dipeptide that can be isolated from N. minutum (NIES-26). The structure of Nostopeptin B contains Ahp (3-amino-6-hydroxy-2-piperidone), which exhibits effective inhibition against *elastase* and chymotrypsin .

HY-N1719

Isoarjunolic acid 2α,3α,23-Trihydroxyolean-12-en-28-oic acid	Rhododendron collettianum Aitch. & Hemsl. Plants Ericaceae	Others
Isoarjunolic acid (2α,3α,23-Trihydroxyolean-12-en-28-oic acid) is a triterpenoid, can be isolated from the stems of Cornus kousa. Isoarjunolic acid could have free radical scavenging activity and elastase inhibition activity .

HY-N12742

Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside	Flavonoids Flavones Astragalus thracicus Griseb. Phenols Plants Source Classification Fabaceae	Others
Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside (compound 4) is an inhibitor of collagenase and elastase with potential anti-inflammatory activity. Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside can be isolated from the methanol extract of the Balkan endemic species Astragalus thracicus Griseb .

HY-N1942R

5-O-Demethylnobiletin (Standard) 5-Demethylnobiletin (Standard)	Structural Classification Flavonoids Flavones Rutaceae Plants Citrus	Reference Standards Lipoxygenase Leukotriene Receptor
5-O-Demethylnobiletin (Standard) is the analytical standard of 5-O-Demethylnobiletin. This product is intended for research and analytical applications. 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC₅₀=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC₅₀ of 0.35 μM .

HY-N19660

(1'S,2'S)-1'-O-Methylvaginol	Structural Classification Flavonoids Carlina acaulis L. Plants Umbelliferae Other Flavonoids Source Classification	Elastase
(1'S,2'S)-1'-O-Methylvaginol, a coumarin found in the fruits of Cnidium monnieri, is an *elastase* inhibitor. (1'S,2'S)-1'-O-Methylvaginol exhibits 11.99% inhibition of superoxide anion generation and 6.42% inhibition of elastase release by human neutrophils at 10 µg/mL. (1'S,2'S)-1'-O-Methylvaginol can be used for research on inflammatory diseases .

HY-N17409

Eupatobenzofuran	Structural Classification Simple Phenylpropanols Phenylpropanoids Plants Compositae Guilandina minax (Hance) G. P. Lewis Source Classification	Drug Derivative
Eupatobenzofuran is a dihydrobenzofuran derivative that can be found in the aerial part of Eupatorium cannabinum subsp. asiaticum. Eupatobenzofuran inhibits fMLP/CB-induced elastase release by human neutrophils with an IC₅₀ value of 11.3 μM .

HY-N19297

Endosidin1 Prieurianin	Structural Classification Natural Products Arabidopsis thaliana (L.) Heynh. Plants Brassicaceae Source Classification	Elastase
Endosidin1 (Prieurianin) is a Prieurianin with cleaved A and B rings. Endosidin1 is isolated from the roots of Aphanamixis polystachya. Endosidin1 inhibits superoxide anion production and *Elastase* release in neutrophils, with an IC₅₀ >10 μg/mL. Endosidin1 exhibits mild cytotoxic activity against laryngeal cancer cells in vitro. Endosidin1 shows anti-inflammatory activity. Endosidin1 can be used in studies related to laryngeal cancer .\n

HY-N17881

Phochinenin K	Structural Classification Bletilla formosana (Hayata) Schltr. Orchidaceae Lignans Phenylpropanoids Plants Source Classification	Elastase
Phochinenin K is a 9,10-dihydrophenanthrene derivative present in the rhizomes of Bletilla formosana. Phochinenin K exhibits anti-inflammatory activity and can be used in the study of inflammatory diseases .

HY-N17365

2-Hydroxy-2,6-dimethyl-3-benzofuranone	Structural Classification Natural Products Plants Compositae Guilandina minax (Hance) G. P. Lewis Source Classification	Drug Derivative
2-Hydroxy-2,6-dimethyl-3-benzofuranone (compound 4) is a benzofuranone derivative that can be found in the aerial part of Eupatorium cannabinum subsp. asiaticum .

HY-N17997

Pilosulyne D	Structural Classification Ketones, Aldehydes, Acids Campanulaceae Codonopsis pilosula (Franch.) Nannf. Plants Source Classification	Others
Pilosulyne D is a polyyne found in the roots of Codonopsis pilosula .

Species:	Human (6) Rat (1) Mouse (2) Cynomolgus (1) Pig (1)
Tag:	His (10) Myc (2) GST (1)
Source:	HEK293 (4) P. pastoris (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72179

	ELANE Protein, Human (GST) Bone marrow serine protease; ELA2; ELANE; elastase 2; elastase 2 neutrophil; elastase neutrophil expressed; elastase-2; ELNE_HUMAN; GE; Granulocyte derived elastase; HLE; HNE; Human leukocyte elastase; Leukocyte elastase; Medullasin; NE; Neutrophil elastase; PMN E; PMN elastase; Polymorphonuclear elastase; SCN1	Human	E. coli
	ELANE is a serine protease that critically regulates natural killer cells, monocytes, and granulocytes by inhibiting C5a-dependent neutrophil enzyme release and chemotaxis, thereby shaping immune responses. It also inhibits pyroptosis by cleaving GSDMB, affecting the regulation of programmed cell death. ELANE Protein, Human (GST) is the recombinant human-derived ELANE protein, expressed by E. coli , with N-GST labeled tag.

HY-P71638

	Elastase IIIB/CELA3B Protein, Mouse (Myc, His) Cela3b; Ela3; Ela3b; Chymotrypsin-like elastase family member 3B; EC 3.4.21.70; elastase IIIB; elastase-3B; Protease E	Mouse	E. coli
	The elastase IIIB/CELA3B protein exhibits remarkable efficiency as a protease, showing a clear preference for alanine specificity while exhibiting limited elastolytic activity. This unique zymogram makes this protein a promising candidate for precise substrate cleavage, especially when processing alanine-rich substrates. Elastase IIIB/CELA3B Protein, Mouse (Myc, His) is the recombinant mouse-derived Elastase IIIB/CELA3B protein, expressed by E. coli , with N-His, C-Myc labeled tag.

HY-P70133

	CELA3A Protein, Human (HEK293, His) rHuChymotrypsin-like elastase family member 3A/CELA3A, His; Chymotrypsin-Like elastase Family Member 3A; elastase IIIA; elastase-3A; Protease E; CELA3A; ELA3; ELA3A	Human	HEK293
	CELA3A Protein, an efficient alanine-specific protease, exhibits minimal elastolytic activity. CELA3A Protein, Human (HEK293, His) is the recombinant human-derived CELA3A protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72136

	CELA2A Protein, Mouse (His) Cela2a; Ela-2; Ela2; Ela2aChymotrypsin-like elastase family member 2A; EC 3.4.21.71; elastase-2; elastase-2A	Mouse	E. coli
	CELA2A Protein, a serine protease, is involved in the digestion of dietary proteins in the small intestine. It cleaves peptide bonds, breaking down proteins into smaller peptides and amino acids for absorption. CELA2A Protein, Mouse (His) is the recombinant mouse-derived CELA2A protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71303

	Serpin B1 Protein, Human (HEK293, His) 1 Publications Verification Leukocyte elastase inhibitor; SERPINB1; Monocyte/neutrophil elastase inhibitor; M/NEI; Peptidase inhibitor 2; PI-2	Human	HEK293
	Serpin B1 protein is an important neutrophil serine protease inhibitor that regulates innate immune responses by protecting cells from cytoplasmic proteases during stress. It inhibits various neutrophil proteases, including elastase and chymotrypsin, and blocks GZMH activity intracellularly. Serpin B1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin B1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72135

	CELA2A Protein, Human (His) CELA2A; ELA2A; Chymotrypsin-like elastase family member 2A; EC 3.4.21.71; elastase-2A	Human	E. coli
	The function of the CELA2A protein as elastase goes beyond its traditional role as it not only enhances insulin signaling but also appears to play a potential physiological role in cellular glucose metabolism. This multifaceted protein circulates in the plasma and exerts regulatory effects by reducing platelet overactivation. CELA2A Protein, Human (His) is the recombinant human-derived CELA2A protein, expressed by E. coli , with N-6*His labeled tag.

HY-P703804

	MME Protein, Cynomolgus (HEK293, His) Neprilysin; Atriopeptidase; Enkephalinase; Neutral endopeptidase 24.11; Skin fibroblast elastase; MME;	Cynomolgus	HEK293
	MME Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived MME protein, expressed by HEK293, with N-His tag.

HY-P72289

	Serpin B1 Protein, Pig (His, Myc) SERPINB1; ELANH2Leukocyte elastase inhibitor; LNPI; Serpin B1	Pig	E. coli
	The leukocyte elastase inhibitor/SERPINB1 protein is an important neutrophil serine protease inhibitor that regulates innate immune responses by protecting cells from cytoplasmic proteases during stress. It inhibits various neutrophil proteases, including elastase and chymotrypsin, and blocks GZMH activity intracellularly. Serpin B1 Protein, Pig (His, Myc) is the recombinant pig-derived Leukocyte elastase inhibitor/SERPINB1 protein, expressed by E. coli , with N-His, C-Myc labeled tag.

HY-P705514

	MMP-12 Protein, Human (His) EC 3.4.24.65; HME; Macrophage elastase; Macrophage metalloelastase; Macrophage metaloelastase; Matrix metallopeptidase 12 (macrophage elastase); Matrix metalloprotease 12; Matrix metalloproteinase-12; ME; MGC138506; MME; MMP 12; MMP-12; Mmp12; MMP12_HUMAN	Human	E. coli

HY-P71726

	Complement Factor D/Adipsin Protein, Rat (P.pastoris, His) Cfd; Adn; Df; Complement factor D; EC 3.4.21.46; Adipsin; C3 convertase activator; Endogenous vascular elastase; Properdin factor D	Rat	P. pastoris
	Complement Factor D/Adipsin Protein is pivotal, cleaving factor B within the factor C3b complex to activate the C3bbb complex, serving as the C3 convertase in the alternate pathway—analogous to C1s in the classical pathway. Complement Factor D/Adipsin Protein, Rat (P.pastoris, His) is the recombinant rat-derived Complement Factor D/Adipsin protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P70316

	Elafin/Trappin-2 Protein, Human (HEK293, His) rHuElafin, His; Elafin; elastase-Specific Inhibitor; ESI; Peptidase Inhibitor 3; PI-3; Protease inhibitor WAP3; Skin-Derived Antileukoproteinase; SKALP; WAP Four-Disulfide Core Domain Protein 14; PI3; WAP3; WFDC14	Human	HEK293
	Elafin/Trappin-2, a skin-specific inhibitor of neutrophil and pancreatic elastase, safeguards tissues against elastase-mediated proteolysis. Its inhibitory range extends to the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor. Elafin/Trappin-2 also weakly inhibits Kv11.1/KCNH2/ERG1 and transient receptor potential cation channel subfamily V member 1 (TRPV1), as reported in studies. Elafin/Trappin-2 Protein, Human (HEK293, His) is the recombinant human-derived Elafin/Trappin-2 protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0149S1

Tranexamic acid-d2-1
Tranexamic acid-d₂-1 is the deuterium labeled Tranexamic acid . Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC₅₀ of 5 mM .

Host:	Mouse (5) Rabbit (6)
Reactivity:	Human (10) Rat (5) Mouse (3) Monkey (2) human (1) Hamster (2)
Application:	IHC-P (8) ICC/IF (6) IF-Tissue (1) IP (6) WB (10) FC (3) ELISA (6)
Isotype:	IgG (6) IgG1 (2) IgG2a (1)
Conjugation:	Non-conjugated (11)
Clonality:	Monoclonal (8) Recombinant (3)
Modification:	Unmodified (9)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81215

	*Neutrophil Elastase* Antibody (YA3528)** Bone Marrow Serine Protease; ELA 2; ELA2; ELANE; elastase 2; elastase-2; elastase 2 neutrophil; elastase neutrophil expressed; elastase-2; ELNE_HUMAN; GE antibody Granulocyte derived elastase; HLE; HNE; Human leukocyte elastase; Leukocyte elastase; Leukocyte elastase Precursor; Medullasin; NE; Neutrophil elastase; Neutrophill elastase; PMN E; PMN elastase; Polymorphonuclear elastase; SCN1; Serine protease; SERP1.	WB, IHC-P, ICC/IF, FC	Human, Mouse
	Neutrophil Elastase Antibody (YA3528) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Neutrophil Elastase.

HY-P810004

	Elastase-3A Antibody (YA9348) ELA3B, CELA3B, Chymotrypsin-like elastase family member 3B, elastase IIIB, elastase-3B, Protease E	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human
	Elastase-3A Antibody (YA9348) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Elastase-3A.

HY-P86073

	*Neutrophil Elastase* Antibody (YA5765)**	WB, ICC/IF, IP, ELISA	Human
	Neutrophil Elastase Antibody (YA5765) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Neutrophil Elastase.

HY-P84004

	*Neutrophil Elastase* Antibody (YA3701)** GE; NE; HLE; HNE; ELA2; SCN1; PMN-E	WB, IHC-P, FC, ELISA	Human, Monkey
	Neutrophil Elastase Antibody (YA3701) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Neutrophil Elastase.

HY-P84004A

	*Neutrophil Elastase* Antibody (YA3701)(PBS only)** GE; NE; HLE; HNE; ELA2; SCN1; PMN-E	WB, IHC-P, FC, ELISA	Human, Monkey
	Neutrophil Elastase Antibody (YA3701) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Neutrophil Elastase.

HY-P80755

	MMP12 Antibody (YA288) Macrophage metalloelastase; MME; 3.4.24.65; Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12; MMP12; HME	WB, IP	Human, Rat, Hamster
	MMP12 Antibody (YA288) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP12.

HY-P80755A

	MMP12 Antibody (YA288)(PBS only) Macrophage metalloelastase; MME; 3.4.24.65; Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12; MMP12; HME	WB, IP	Human, Rat, Hamster
	MMP12 Antibody (YA288) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP12.

HY-P81568

	CD10 Antibody (YA1313) CALLA, NEP,Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD10	WB, IHC-P, IP	Human, Rat
	CD10 Antibody (YA1313) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD10.

HY-P86377

	CD10 Antibody (YA6069) MME; EPN; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD10	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	CD10 Antibody (YA6069) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CD10.

HY-P85660

	CD10 Antibody (YA5352) MME; EPN; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD10	ICC/IF, IHC-P	Human, Mouse, Rat
	CD10 Antibody (YA5352) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD10.

HY-P85080

	CD10 Antibody (YA4772) MME; EPN; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD antigen CD10	WB, IHC-P, ICC/IF, ELISA	Human
	CD10 Antibody (YA4772) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD10.

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Cat. No.	Product Name		Classification

HY-160225

ISD sodium 4 Publications Verification		CpG ODNs
ISD sodium is an interferon-stimulatory DNA, a 45 bp non-CpG double-stranded oligonucleotide derived from the genome of Listeria monocytogenes. ISD sodium potently induces type I interferon production via the cGAS‑STING‑TBK1‑IRF3 pathway .

HY-107965

Safflower oil (from Carthamus tinctorius seed) Safflower seed oil (from Carthamus tinctorius seed)		Solvents
Safflower oil (from Carthamus tinctorius seed) is rich in unsaturated fatty acids such as linoleic acid and oleic acid, as well as tocopherols and phenolic compounds, and exhibits antioxidant, anti-aging and blood lipid-regulating effects. Safflower oil (from Carthamus tinctorius seed) inhibits the activities of collagenase and *elastase, and exerts antioxidant activity by scavenging free radicals. Linoleic acid in safflower oil (from Carthamus tinctorius* seed) reduces blood cholesterol levels. Safflower oil (from Carthamus tinctorius seed) can be applied to research in fields such as skin aging, atherosclerosis, edible oil processing and industrial raw material development .

HY-174719

Human ELANE mRNA		mRNA
Human ELANE mRNA encodes the human elastase (ELANE) protein, a member of serine proteases family. ELANE may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin.

HY-174540

Human SERPINA1 mRNA		mRNA
Human SERPINA1 mRNA encodes the human serpin family A member 1 (SERPINA1) protein, a serine protease inhibitor belonging to the serpin superfamily. SERPINA1’s major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

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elastase

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