Anti-Human/Monkey CD16a Antibody (3G8)

Cat. No.: HY-P991998: Data Sheet
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Anti-Human/Monkey CD16a Antibody (3G8) is a monoclonal antibody targeting CD16a. Anti-Human/Monkey CD16a Antibody (3G8) blocks FcγRIII/CD16a, upregulates the metabolic activity of CD16+ cells, downregulates CD87, a poor prognostic marker, and inhibits the engraftment and growth of leukemia cells in acute myeloid leukemia, and rapidly increases platelet counts in immune thrombocytopenia. Anti-Human/Monkey CD16a Antibody (3G8) is applicable to research related to tumor immunology.

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Anti-Human/Monkey CD16a Antibody (3G8) Chemical Structure

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Description	Anti-Human/Monkey CD16a Antibody (3G8) is a monoclonal antibody targeting CD16a. Anti-Human/Monkey CD16a Antibody (3G8) blocks FcγRIII/CD16a, upregulates the metabolic activity of CD16+ cells, downregulates CD87, a poor prognostic marker, and inhibits the engraftment and growth of leukemia cells in acute myeloid leukemia, and rapidly increases platelet counts in immune thrombocytopenia. Anti-Human/Monkey CD16a Antibody (3G8) is applicable to research related to tumor immunology^[1]^[2].
Isotype	Mouse IgG1 kappa
Recommend Isotype Controls	Mouse IgG1 kappa, Isotype Control
Species Reactivity	Human
In Vitro	Anti-Human/Monkey CD16a Antibody (3G8) increases the metabolic activity of CD16a+ MOLM-13 acute myeloid leukemia cell cultures^[1]. Anti-Human/Monkey CD16a Antibody (3G8) (24 h) induces CD16a+ MOLM-13 acute myeloid leukemia cells to downregulate the unfavorable prognostic marker CD87^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Anti-Human/Monkey CD16a Antibody (3G8) Related Antibodies
In Vivo	Anti-Human/Monkey CD16a Antibody (3G8) inhibits engraftment of CD16a+ MOLM-13 acute myeloid leukemia cells in NSG mice^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID	2214 [NCBI]
Accession	P08637
Target	CD16a
Application	ELISA, FACS, Functional assay
Conjugated	Unconjugated
Reconsititution	The product can be reconstituted/diluted with sterile PBS or saline.
SMILES	[Anti-Human/Monkey CD16a Antibody (3G8)]
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (257 KB) Inhibitory Antibodies User Guide (603 KB)
References	[1]. Prada B D. Uncovering the Functionality of CD16a on Acute Myeloid Leukemia Cells. Icahn School of Medicine at Mount Sinai, 2023. [2]. Xu M, Feng Q, et al. Blocking FcγRIII with anti-CD16 mab (3G8 and GMA161) increases platelets in immune thrombocytopenia: Two pilot studies. Blood, 2025, 146: 4821.