Anti-Human/Monkey CD16a Antibody (3G8) 

Anti-Human/Monkey CD16a Antibody (3G8) is a monoclonal antibody targeting CD16a. Anti-Human/Monkey CD16a Antibody (3G8) blocks FcγRIII/CD16a, upregulates the metabolic activity of CD16+ cells, downregulates CD87, a poor prognostic marker, and inhibits the engraftment and growth of leukemia cells in acute myeloid leukemia, and rapidly increases platelet counts in immune thrombocytopenia. Anti-Human/Monkey CD16a Antibody (3G8) is applicable to research related to tumor immunology^[1][2].

Mouse IgG1 kappa

Mouse IgG1 kappa, Isotype Control

Human

Anti-Human/Monkey CD16a Antibody (3G8) increases the metabolic activity of CD16a+ MOLM-13 acute myeloid leukemia cell cultures^[1].
Anti-Human/Monkey CD16a Antibody (3G8) (24 h) induces CD16a+ MOLM-13 acute myeloid leukemia cells to downregulate the unfavorable prognostic marker CD87^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Human/Monkey CD16a Antibody (3G8) inhibits engraftment of CD16a+ MOLM-13 acute myeloid leukemia cells in NSG mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2214  [NCBI]

P08637

CD16a

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

[Anti-Human/Monkey CD16a Antibody (3G8)]

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Prada B D. Uncovering the Functionality of CD16a on Acute Myeloid Leukemia Cells. Icahn School of Medicine at Mount Sinai, 2023.

  [2]. Xu M, Feng Q, et al. Blocking FcγRIII with anti-CD16 mab (3G8 and GMA161) increases platelets in immune thrombocytopenia: Two pilot studies. Blood, 2025, 146: 4821.