Neutrophil elastase inhibitor 1

Name: Neutrophil elastase inhibitor 1
Brand: MedChemExpress
SKU: HY-118177
Rating: 4.5 (0 reviews)

Cat. No.: HY-118177 Pureza: 98.22%: Ficha de datos
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Neutrophil elastase inhibitor 1 is a competitive, pseudo-reversible inhibitor of human neutrophil elastase (HNE) with an IC₅₀ of 7 nM. Neutrophil elastase inhibitor 1 also exhibits inhibitory activity against thrombin, chymotrypsin and urokinase, with IC₅₀ values of 1.9 μM, 66 nM and 6.6 μM, respectively. Neutrophil elastase inhibitor 1 can be used in research related to acute respiratory distress syndrome, chronic obstructive pulmonary disease and other conditions.

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Neutrophil elastase inhibitor 1 Estructura química

No. CAS : 1448314-31-5

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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Descripciòn

IC₅₀ & Target

IC₅₀: 7 nM (Neutrophil elastase), 1.9 μM (Thrombin), 0.066 μM (chymotrypsin), 6.6 μM (urokinase)

In Vitro

Neutrophil elastase inhibitor 1 (Compound 5b) (5 μM; 0-7 h) is a pseudo-irreversible inhibitor of human neutrophil elastase, which maintains a persistent inhibitory effect (80% of that of the control group) even 7 h after treatment with 5 μM of this compound^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

261.28

Fòrmula

C₁₆H₁₁N₃O

No. CAS

1448314-31-5

Appearance

Solid

Color

White to off-white

SMILES

N#CC1=NN(C2=C1C=CC=C2)C(C3=CC=CC(C)=C3)=O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 40 mg/mL (153.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8273 mL	19.1366 mL	38.2731 mL
5 mM	0.7655 mL	3.8273 mL	7.6546 mL
10 mM	0.3827 mL	1.9137 mL	3.8273 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Pureza y Documentación

Purity: 98.22%

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Ficha de datos (276 KB) SDS (393 KB)

COA (255 KB) HNMR (171 KB) LCMS (96 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Crocetti L, et al.. Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase. Journal of medicinal chemistry. 2013 Aug 08;56(15):6259-72. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8273 mL	19.1366 mL	38.2731 mL	95.6828 mL
	5 mM	0.7655 mL	3.8273 mL	7.6546 mL	19.1366 mL
	10 mM	0.3827 mL	1.9137 mL	3.8273 mL	9.5683 mL
	15 mM	0.2552 mL	1.2758 mL	2.5515 mL	6.3789 mL
	20 mM	0.1914 mL	0.9568 mL	1.9137 mL	4.7841 mL
	25 mM	0.1531 mL	0.7655 mL	1.5309 mL	3.8273 mL
	30 mM	0.1276 mL	0.6379 mL	1.2758 mL	3.1894 mL
	40 mM	0.0957 mL	0.4784 mL	0.9568 mL	2.3921 mL
	50 mM	0.0765 mL	0.3827 mL	0.7655 mL	1.9137 mL
	60 mM	0.0638 mL	0.3189 mL	0.6379 mL	1.5947 mL
	80 mM	0.0478 mL	0.2392 mL	0.4784 mL	1.1960 mL
	100 mM	0.0383 mL	0.1914 mL	0.3827 mL	0.9568 mL