Neutrophil elastase inhibitor 1
Based on 1 Customer Validation
Neutrophil elastase inhibitor 1 is a competitive, pseudo-reversible inhibitor of human neutrophil elastase (HNE) with an IC50 of 7 nM. Neutrophil elastase inhibitor 1 also exhibits inhibitory activity against thrombin, chymotrypsin and urokinase, with IC50 values of 1.9 μM, 66 nM and 6.6 μM, respectively. Neutrophil elastase inhibitor 1 can be used in research related to acute respiratory distress syndrome, chronic obstructive pulmonary disease and other conditions.
For research use only. We do not sell to patients.
- Purity: 98.22%
- CAS No.: 1448314-31-5
- Formula: C16H11N3O
- Molecular Weight:261.28
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 7 nM (Neutrophil elastase), 1.9 μM (Thrombin), 0.066 μM (chymotrypsin), 6.6 μM (urokinase)
Neutrophil elastase inhibitor 1 (Compound 5b) (5 μM; 0-7 h) is a pseudo-irreversible inhibitor of human neutrophil elastase, which maintains a persistent inhibitory effect (80% of that of the control group) even 7 h after treatment with 5 μM of this compound[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1448314-31-5
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Appearance Solid
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Molecular Weight 261.28
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Formula C16H11N3O
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Color White to off-white
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SMILES
N#CC1=NN(C2=C1C=CC=C2)C(C3=CC=CC(C)=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 40 mg/mL (153.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8273 mL | 19.1366 mL | 38.2731 mL | 95.6828 mL |
| 5 mM | 0.7655 mL | 3.8273 mL | 7.6546 mL | 19.1366 mL | |
| 10 mM | 0.3827 mL | 1.9137 mL | 3.8273 mL | 9.5683 mL | |
| 15 mM | 0.2552 mL | 1.2758 mL | 2.5515 mL | 6.3789 mL | |
| 20 mM | 0.1914 mL | 0.9568 mL | 1.9137 mL | 4.7841 mL | |
| 25 mM | 0.1531 mL | 0.7655 mL | 1.5309 mL | 3.8273 mL | |
| 30 mM | 0.1276 mL | 0.6379 mL | 1.2758 mL | 3.1894 mL | |
| 40 mM | 0.0957 mL | 0.4784 mL | 0.9568 mL | 2.3921 mL | |
| 50 mM | 0.0765 mL | 0.3827 mL | 0.7655 mL | 1.9137 mL | |
| 60 mM | 0.0638 mL | 0.3189 mL | 0.6379 mL | 1.5947 mL | |
| 80 mM | 0.0478 mL | 0.2392 mL | 0.4784 mL | 1.1960 mL | |
| 100 mM | 0.0383 mL | 0.1914 mL | 0.3827 mL | 0.9568 mL |
Neutrophil elastase inhibitor 1 Related Classifications
HY-118177 Related Classifications
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- Neutrophil elastase inhibitor 1
- 1448314-31-5
- Neutrophil elastase inhibitor1
- Neutrophil elastase inhibitor-1
- Elastase
- Thrombin
- Ser/Thr Protease
- human thrombin
- atherosclerosis
- serine proteases
- dermatitis
- non-small cell lung cancer
- acute respiratory distress syndrome
- chronic obstructive pulmonary disease
- psoriasis
- human neutrophil elastase
- cystic fibrosis
- Inhibitor
- inhibitor
- inhibit