2. Anti-infection
  3. Bacterial
  4. Quoromycin

Quoromycin is an orally active SmcR inhibitor with a Kd of 0.697 μM for Vibrio vulnificus SmcR. Quoromycin binds directly to SmcR, reduces its DNA-binding affinity, and inhibits the quorum sensing signaling pathway. Quoromycin is applicable to the research of Vibrio vulnificus infection.

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Quoromycin

Quoromycin Chemical Structure

CAS No. : 205514-29-0

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Quoromycin Related Antibodies

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Description

Quoromycin is an orally active SmcR inhibitor with a Kd of 0.697 μM for Vibrio vulnificus SmcR. Quoromycin binds directly to SmcR, reduces its DNA-binding affinity, and inhibits the quorum sensing signaling pathway. Quoromycin is applicable to the research of Vibrio vulnificus infection[1].

In Vitro

Quoromycin binds directly to Vibrio vulnificus SmcR protein with a Kd of 0.697 μM[1].
Quoromycin (1-50 μM) dose-dependently inhibits the binding of Vibrio vulnificus SmcR to the vvpE promoter DNA without altering SmcR protein levels[1].
Quoromycin (1-50 μM; 25 h) dose-dependently reduces elastase activity in Vibrio vulnificus without inhibiting bacterial growth[1].
Quoromycin (1-50 μM; 12 h) inhibits Vibrio vulnificus vvpE promoter activity with an IC50 of 322 nM[1].
Quoromycin (20 μM) reduces vvpE transcript levels, elastase activity, and exoprotease activity in wild-type Vibrio vulnificus to levels similar to an smcR mutant strain[1].
Quoromycin (1-100 μM; 3 h at 37 °C) dose-dependently reduces Vibrio vulnificus-induced cytotoxicity and bacterial adhesion to INT-407 human intestinal epithelial cells[1].
Quoromycin (20 μM) inhibits quorum sensing in Vibrio harveyi and reduces proteolytic activity in Vibrio anguillarum without inhibiting bacterial growth of either species[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Quoromycin Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: INT-407 human intestinal epithelial cells infected with Vibrio vulnificus
Concentration: 1, 10, 25, 50, 100 μM
Incubation Time: 3 h at 37 °C
Result: Reduced Vibrio vulnificus-induced cytotoxicity in INT-407 cells in a dose-dependent manner, with 100 μM quoromycin returning LDH levels to non-infected control levels.
Reduced Vibrio vulnificus adhesion to INT-407 cells in a dose-dependent manner, with 50 μM quoromycin reducing adherent CFUs by half compared to controls.
In Vivo

Quoromycin (61-122 μg/kg; i.g.; single simultaneous dose with infection) confers 60% 24-hour survival in mice intragastrically infected with V. vulnificus biofilms, significantly prolonging survival relative to untreated controls[1].
Quoromycin (122 μg/kg; i.g.; single simultaneous dose with infection) significantly reduces V. vulnificus colonization in mouse small intestine, liver, and spleen, and prevents infection-associated tissue damage[1].
Quoromycin (30-122 μg/kg; i.g.; single dose) shows no acute in vivo cytotoxicity in healthy ICR female mice, with 100% 24-hour survival[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR (female, 7-week-old, pathogen-free)[1]
Dosage: 61 μg/kg; 122 μg/kg
Administration: i.g.; single simultaneous dose with infection
Result: Conferred 60% 24-hour survival at 122 μg/kg (vs 10% in untreated controls).
Significantly prolonged survival at 61 μg/kg relative to untreated infected mice.
Animal Model: ICR (female, pathogen-free)[1]
Dosage: 122 μg/kg
Administration: i.g.; single simultaneous dose with infection
Result: Reduced small intestine colonization index to ~-3 log.
Reduced liver colonization index to ~-4.5 log.
Reduced spleen colonization index to ~-5 log.
Prevented edema, hemorrhage, vasodilation, necrosis, and intestinal inflammation/swelling observed in untreated infected mice.
Molecular Weight

244.27

Formula

C12H8N2O2S
CAS No.
SMILES

N#CC1=CN=C(C=C1)S(=O)(=O)C=2C=CC=CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Quoromycin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quoromycin205514-29-0BacterialVibrio vulnificusVibrio vulnificus infectionelastase activityVibrio harveyiSmcRquorum-sensing signaling pathwayVibrio anguillarumICR female micevvpE promoter DNAINT-407 human intestinal epithelial cellsInhibitorinhibitorinhibit

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