1. Metabolic Enzyme/Protease
  2. Elastase
  3. Lonodelestat

Lonodelestat (Synonyms: POL6014)

Cat. No.: HY-P3293
Handling Instructions

Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Lonodelestat Chemical Structure

Lonodelestat Chemical Structure

CAS No. : 906547-89-5

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Description

Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE)[1][2].

In Vivo

Lonodelestat (POL6014) significantly and efficiently reduced the inflammatory processes of ALI in HNE treated mice[1].
Lonodelestat (POL6014, 0.1, 0.5, 2 and 10 mg/kg, intranasally administered) dose-dependently and significantly reduces the number of macrophages, epithelial cells, neutrophils and lymphocytes recovered in BAL. The maximum inhibition was reached at 2 mg/kg in reducing neutrophils by 65% (p<0.001), epithelial cells by 68% (p<0.001), macrophages by 33% (p<0.001) and lymphocytes by 77% (p<0.001)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ten-week-old male C57BL/6j mice[1].
Dosage: 0.05, 0.2, 0.5 and 5 mg/kg.
Administration: Administered intranasally (i.n.) 15 minutes before HNE (30 UI, i.n.).
Result: Reduced the inflammatory processes of ALI in HNE treated mice.
Molecular Weight

1478.73

Formula

C₇₁H₁₁₁N₁₅O₁₉

CAS No.
Sequence Shortening

cyclo[ASIPPQKYPPNle(bu)ET]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Lonodelestat
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