906547-89-5
Chemical Structure
Lonodelestat
Synonym(s): POL6014
- CAS No.: 906547-89-5
- Formula:C71H111N15O19
- Molecular Weight:1478.73
InChIKey: JMWYNUHGKFJVIB-QGFXQWJDSA-N
SMILES: O=C(N(CCC1)[C@]1([H])C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H]2CO)=O)C)=O)([H])[C@H](O)C)=O)CCC(O)=O)=O)CCCCCCCC)=O)[C@](CCC3)([H])N3C([C@@H](NC([C@@H](NC([C@@H](NC([C@@](CCC4)([H])N4C([C@@](CCC5)([H])N5C([C@](NC2=O)([H])[C@@H](C)CC)=O)=O)=O)CCC(N)=O)=O)CCCCN)=O)CC(C=C6)=CC=C6O)=O
Biological Activity: Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF)[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lonodelestat | 99.59% | Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF). | ||||||||||||||||||||
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- [1]. Lagente V, et al. A novel Protein Epitope Mimetic (PEM) neutrophil elastase (NE) inhibitor, POL6014, inhibits human NE-induced acute lung injury in mice. ATS, San Diego, May 15-20, 2009.
- [2]. Odile Sellier-Kessler, et al. Inhibition of lung inflammation by a protein epitope mimetic (PEM) neutrophil elastase inhibitor, POL6014, in a sub-chronic tobacco smoke (TS) model in mice. European Respiratory Journal 2013 42: 1762.
- [3]. Barth P, et al. Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis. J Cyst Fibros. 2020 Mar;19(2):299-304. [Content Brief]
Keywords
