Neutrophil Elastase Antibody (YA3701)
(Synonyms: GE; NE; HLE; HNE; ELA2; SCN1; PMN-E)Neutrophil Elastase Antibody (YA3701) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Neutrophil Elastase.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, FC, ELISA
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Reactivity :
Human, Monkey
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
Neutrophil Elastase Antibody (YA3701) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Neutrophil Elastase.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Monkey
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Observed Molecular WeightObserved band size: 29 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 29 kDa
Purified recombinant fragment of human ELANE (AA: 140-267) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Neutrophil Elastase serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis. Promotes blood coagulation. Through the activation of the platelet fibrinogen receptor integrin alpha-IIb/beta-3, potentiates platelet aggregation induced by a threshold concentration of cathepsin G (CTSG). Cleaves and thus inactivates tissue factor pathway inhibitor (TFPI). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae[1][2][3][4][5][6].
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Subcellular Localization
Cytoplasmic vesicle, phagosome
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Expression
Tissue_specificity:Bone marrow cells. Neutrophils (PubMed: 10947984) -
Subunit
Interacts with NOTCH2NL (PubMed:14673143). Interacts with agaphelin, an antihemostatic protein from Anopheles gambiae (PubMed:25211214)
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SwissProt ID
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Synonyms
GE; NE; HLE; HNE; ELA2; SCN1; PMN-E
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